pH j , contractility and Ca-balance under hypercapnic acidosis in the myocardium of different vertebrate species.
Udgivelsesdato: Feb The influence of hypercapnic acidosis upon the heart was examined in four vertebrate species. The CO2 in the tissue bath was increased from 2.7 to 15% at 12 degrees C for flounder (Platichthys flesus) and cod (Gadus morhua) and from 3 to 13% at 22 degrees C for turtle (Pseudemys...
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1982
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ftuniaarhuspubl:oai:pure.atira.dk:publications/c4884310-126a-11dc-bee9-02004c4f4f50 2023-05-15T16:19:16+02:00 pH j , contractility and Ca-balance under hypercapnic acidosis in the myocardium of different vertebrate species. Gesser, H Bonefeld-Jørgensen, Eva Cecilie 1982 https://pure.au.dk/portal/da/publications/phj-contractility-and-cabalance-under-hypercapnic-acidosis-in-the-myocardium-of-different-vertebrate-species(c4884310-126a-11dc-bee9-02004c4f4f50).html eng eng info:eu-repo/semantics/restrictedAccess Gesser , H & Bonefeld-Jørgensen , E C 1982 , ' pH j , contractility and Ca-balance under hypercapnic acidosis in the myocardium of different vertebrate species. ' , Journal of Experimental Biology , vol. 96 , pp. 405-12 . article 1982 ftuniaarhuspubl 2020-07-18T20:45:47Z Udgivelsesdato: Feb The influence of hypercapnic acidosis upon the heart was examined in four vertebrate species. The CO2 in the tissue bath was increased from 2.7 to 15% at 12 degrees C for flounder (Platichthys flesus) and cod (Gadus morhua) and from 3 to 13% at 22 degrees C for turtle (Pseudemys scripta) and rainbow trout (Salmo gairdneri). During hypercapnia, as previously described, there was a decline and recovery of contractility in heart strips of flounder and turtle, and a sustained decrease in cod and rainbow trout. At high CO2 the increase in contractile force following increases in the extracellular Ca-concentration were smaller for the cod myocardium than for the other myocardia. The intracellular pH (pHi), measured with the DMO method, in heart strips of turtle and trout was significantly lower at high than at low CO2. This acidifying effect expressed as the increase in the intracellular concentration of hydrogen ions was larger in the turtle than in the trout myocardium. Intracellular Ca-activity, measured by efflux of 45Ca from preloaded heart strips, was unaffected by high CO2 in trout, but was raised in the other three species. Thus the ability to counteract the negative inotropic effect of hypercapnia is apparently not due to cellular buffering or extrusion of hydrogen ions. More probably it involves (a) a release of intracellular Ca; (b) a positive inotropic effect of an increase in intracellular Ca-activity. Article in Journal/Newspaper Gadus morhua Aarhus University: Research |
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Aarhus University: Research |
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ftuniaarhuspubl |
language |
English |
description |
Udgivelsesdato: Feb The influence of hypercapnic acidosis upon the heart was examined in four vertebrate species. The CO2 in the tissue bath was increased from 2.7 to 15% at 12 degrees C for flounder (Platichthys flesus) and cod (Gadus morhua) and from 3 to 13% at 22 degrees C for turtle (Pseudemys scripta) and rainbow trout (Salmo gairdneri). During hypercapnia, as previously described, there was a decline and recovery of contractility in heart strips of flounder and turtle, and a sustained decrease in cod and rainbow trout. At high CO2 the increase in contractile force following increases in the extracellular Ca-concentration were smaller for the cod myocardium than for the other myocardia. The intracellular pH (pHi), measured with the DMO method, in heart strips of turtle and trout was significantly lower at high than at low CO2. This acidifying effect expressed as the increase in the intracellular concentration of hydrogen ions was larger in the turtle than in the trout myocardium. Intracellular Ca-activity, measured by efflux of 45Ca from preloaded heart strips, was unaffected by high CO2 in trout, but was raised in the other three species. Thus the ability to counteract the negative inotropic effect of hypercapnia is apparently not due to cellular buffering or extrusion of hydrogen ions. More probably it involves (a) a release of intracellular Ca; (b) a positive inotropic effect of an increase in intracellular Ca-activity. |
format |
Article in Journal/Newspaper |
author |
Gesser, H Bonefeld-Jørgensen, Eva Cecilie |
spellingShingle |
Gesser, H Bonefeld-Jørgensen, Eva Cecilie pH j , contractility and Ca-balance under hypercapnic acidosis in the myocardium of different vertebrate species. |
author_facet |
Gesser, H Bonefeld-Jørgensen, Eva Cecilie |
author_sort |
Gesser, H |
title |
pH j , contractility and Ca-balance under hypercapnic acidosis in the myocardium of different vertebrate species. |
title_short |
pH j , contractility and Ca-balance under hypercapnic acidosis in the myocardium of different vertebrate species. |
title_full |
pH j , contractility and Ca-balance under hypercapnic acidosis in the myocardium of different vertebrate species. |
title_fullStr |
pH j , contractility and Ca-balance under hypercapnic acidosis in the myocardium of different vertebrate species. |
title_full_unstemmed |
pH j , contractility and Ca-balance under hypercapnic acidosis in the myocardium of different vertebrate species. |
title_sort |
ph j , contractility and ca-balance under hypercapnic acidosis in the myocardium of different vertebrate species. |
publishDate |
1982 |
url |
https://pure.au.dk/portal/da/publications/phj-contractility-and-cabalance-under-hypercapnic-acidosis-in-the-myocardium-of-different-vertebrate-species(c4884310-126a-11dc-bee9-02004c4f4f50).html |
genre |
Gadus morhua |
genre_facet |
Gadus morhua |
op_source |
Gesser , H & Bonefeld-Jørgensen , E C 1982 , ' pH j , contractility and Ca-balance under hypercapnic acidosis in the myocardium of different vertebrate species. ' , Journal of Experimental Biology , vol. 96 , pp. 405-12 . |
op_rights |
info:eu-repo/semantics/restrictedAccess |
_version_ |
1766005642065084416 |