Quantitative and qualitative distribution of mercury in organs from arctic sledgedogs: an atomic absorption spectrophotometric and histochemical study of tissue samples from natural long-termed high dietary organic mercury-exposed dogs from Thule, Greenland
Organs from 10 sledgedogs fed methyl mercury-containing organs and meat from predatory marine animals also eaten by humans in the Thule district of Greenland, were examined histochemically for cellular distribution of mercury, and the organ concentrations of mercury were quantified by atomic absorpt...
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ftuniaarhuspubl:oai:pure.atira.dk:publications/bede4063-f6e0-42b0-af23-eeac5b711cd9 2024-05-19T07:33:16+00:00 Quantitative and qualitative distribution of mercury in organs from arctic sledgedogs: an atomic absorption spectrophotometric and histochemical study of tissue samples from natural long-termed high dietary organic mercury-exposed dogs from Thule, Greenland Hansen, J C Danscher, Gorm 1995 https://pure.au.dk/portal/en/publications/bede4063-f6e0-42b0-af23-eeac5b711cd9 eng eng https://pure.au.dk/portal/en/publications/bede4063-f6e0-42b0-af23-eeac5b711cd9 info:eu-repo/semantics/restrictedAccess Hansen , J C & Danscher , G 1995 , ' Quantitative and qualitative distribution of mercury in organs from arctic sledgedogs: an atomic absorption spectrophotometric and histochemical study of tissue samples from natural long-termed high dietary organic mercury-exposed dogs from Thule, Greenland ' , Basic & Clinical Pharmacology & Toxicology , vol. 77 , no. 3 , pp. 189-95 . Aging Animals Chromatography Gas Diet Dogs Environmental Exposure Female Greenland Histocytochemistry Kidney Liver Lymph Nodes Male Methylmercury Compounds Spectrophotometry Atomic Tissue Distribution article 1995 ftuniaarhuspubl 2024-05-01T23:42:47Z Organs from 10 sledgedogs fed methyl mercury-containing organs and meat from predatory marine animals also eaten by humans in the Thule district of Greenland, were examined histochemically for cellular distribution of mercury, and the organ concentrations of mercury were quantified by atomic absorption spectrometry (total Hg). In selected organs the methyl mercuric level was determined by gaschromatography. The highest concentration of total mercury was found in mesenterial lymph nodes followed by liver and kidneys, which indicates that the lymphatic system might play an important role in the regulating transport of mercury to target organs. The concentrations were age-related, and the results suggest that demethylation takes place in all organs except skeletal muscles, but lowest in CNS. The distribution of mercury at cellular and subcellular levels was studied by the autometallographic technique. The atomic absorption spectrometric and autometallographic results were in good agreement. The brain mean concentration in the oldest group was 438 micrograms/kg, a level much lower than what has been reported to cause effects in the human central nervous system. However, if humans over a period of e.g. 50 years eat Arctic marine meat and accumulate mercury in the same way as dogs, the possibility that this may have health implications cannot be entirely excluded. Article in Journal/Newspaper Arctic Arctic Greenland Thule Aarhus University: Research |
institution |
Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
Aging Animals Chromatography Gas Diet Dogs Environmental Exposure Female Greenland Histocytochemistry Kidney Liver Lymph Nodes Male Methylmercury Compounds Spectrophotometry Atomic Tissue Distribution |
spellingShingle |
Aging Animals Chromatography Gas Diet Dogs Environmental Exposure Female Greenland Histocytochemistry Kidney Liver Lymph Nodes Male Methylmercury Compounds Spectrophotometry Atomic Tissue Distribution Hansen, J C Danscher, Gorm Quantitative and qualitative distribution of mercury in organs from arctic sledgedogs: an atomic absorption spectrophotometric and histochemical study of tissue samples from natural long-termed high dietary organic mercury-exposed dogs from Thule, Greenland |
topic_facet |
Aging Animals Chromatography Gas Diet Dogs Environmental Exposure Female Greenland Histocytochemistry Kidney Liver Lymph Nodes Male Methylmercury Compounds Spectrophotometry Atomic Tissue Distribution |
description |
Organs from 10 sledgedogs fed methyl mercury-containing organs and meat from predatory marine animals also eaten by humans in the Thule district of Greenland, were examined histochemically for cellular distribution of mercury, and the organ concentrations of mercury were quantified by atomic absorption spectrometry (total Hg). In selected organs the methyl mercuric level was determined by gaschromatography. The highest concentration of total mercury was found in mesenterial lymph nodes followed by liver and kidneys, which indicates that the lymphatic system might play an important role in the regulating transport of mercury to target organs. The concentrations were age-related, and the results suggest that demethylation takes place in all organs except skeletal muscles, but lowest in CNS. The distribution of mercury at cellular and subcellular levels was studied by the autometallographic technique. The atomic absorption spectrometric and autometallographic results were in good agreement. The brain mean concentration in the oldest group was 438 micrograms/kg, a level much lower than what has been reported to cause effects in the human central nervous system. However, if humans over a period of e.g. 50 years eat Arctic marine meat and accumulate mercury in the same way as dogs, the possibility that this may have health implications cannot be entirely excluded. |
format |
Article in Journal/Newspaper |
author |
Hansen, J C Danscher, Gorm |
author_facet |
Hansen, J C Danscher, Gorm |
author_sort |
Hansen, J C |
title |
Quantitative and qualitative distribution of mercury in organs from arctic sledgedogs: an atomic absorption spectrophotometric and histochemical study of tissue samples from natural long-termed high dietary organic mercury-exposed dogs from Thule, Greenland |
title_short |
Quantitative and qualitative distribution of mercury in organs from arctic sledgedogs: an atomic absorption spectrophotometric and histochemical study of tissue samples from natural long-termed high dietary organic mercury-exposed dogs from Thule, Greenland |
title_full |
Quantitative and qualitative distribution of mercury in organs from arctic sledgedogs: an atomic absorption spectrophotometric and histochemical study of tissue samples from natural long-termed high dietary organic mercury-exposed dogs from Thule, Greenland |
title_fullStr |
Quantitative and qualitative distribution of mercury in organs from arctic sledgedogs: an atomic absorption spectrophotometric and histochemical study of tissue samples from natural long-termed high dietary organic mercury-exposed dogs from Thule, Greenland |
title_full_unstemmed |
Quantitative and qualitative distribution of mercury in organs from arctic sledgedogs: an atomic absorption spectrophotometric and histochemical study of tissue samples from natural long-termed high dietary organic mercury-exposed dogs from Thule, Greenland |
title_sort |
quantitative and qualitative distribution of mercury in organs from arctic sledgedogs: an atomic absorption spectrophotometric and histochemical study of tissue samples from natural long-termed high dietary organic mercury-exposed dogs from thule, greenland |
publishDate |
1995 |
url |
https://pure.au.dk/portal/en/publications/bede4063-f6e0-42b0-af23-eeac5b711cd9 |
genre |
Arctic Arctic Greenland Thule |
genre_facet |
Arctic Arctic Greenland Thule |
op_source |
Hansen , J C & Danscher , G 1995 , ' Quantitative and qualitative distribution of mercury in organs from arctic sledgedogs: an atomic absorption spectrophotometric and histochemical study of tissue samples from natural long-termed high dietary organic mercury-exposed dogs from Thule, Greenland ' , Basic & Clinical Pharmacology & Toxicology , vol. 77 , no. 3 , pp. 189-95 . |
op_relation |
https://pure.au.dk/portal/en/publications/bede4063-f6e0-42b0-af23-eeac5b711cd9 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
_version_ |
1799471350133293056 |