Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts
BACKGROUND: Perfluoroalkyl acids (PFAAs) are persistent and bioaccumulating compounds, which are spread all over the globe. We aimed to compare the PFAA concentrations in serum from pregnant women in five birth cohorts from four countries (Denmark, China, Norway, and Greenland). METHODS: Serum sampl...
Published in: | International Journal of Hygiene and Environmental Health |
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Online Access: | https://pure.au.dk/portal/da/publications/maternal-serum-concentrations-of-perfluoroalkyl-acids-in-five-international-birth-cohorts(a717df25-bd14-42fb-91cc-769c95d2a8c3).html https://doi.org/10.1016/j.ijheh.2016.12.005 |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/a717df25-bd14-42fb-91cc-769c95d2a8c3 2023-12-31T10:07:24+01:00 Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts Bjerregaard-Olesen, Christian Bossi, Rossana Liew, Zeyan Long, Manhai Bech, Bodil H Olsen, Jørn Henriksen, Tine B Berg, Vivian Nøst, Therese H Zhang, Jun J Bonefeld-Jørgensen, Eva C 2017-03 https://pure.au.dk/portal/da/publications/maternal-serum-concentrations-of-perfluoroalkyl-acids-in-five-international-birth-cohorts(a717df25-bd14-42fb-91cc-769c95d2a8c3).html https://doi.org/10.1016/j.ijheh.2016.12.005 eng eng https://pure.au.dk/portal/da/publications/maternal-serum-concentrations-of-perfluoroalkyl-acids-in-five-international-birth-cohorts(a717df25-bd14-42fb-91cc-769c95d2a8c3).html info:eu-repo/semantics/closedAccess Bjerregaard-Olesen , C , Bossi , R , Liew , Z , Long , M , Bech , B H , Olsen , J , Henriksen , T B , Berg , V , Nøst , T H , Zhang , J J & Bonefeld-Jørgensen , E C 2017 , ' Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts ' , International Journal of Hygiene and Environmental Health , vol. 220 , no. 2 Pt A , pp. 86–93 . https://doi.org/10.1016/j.ijheh.2016.12.005 China Denmark Exposure profiles Greenland Norway Perfluorinated compounds article 2017 ftuniaarhuspubl https://doi.org/10.1016/j.ijheh.2016.12.005 2023-12-07T00:01:50Z BACKGROUND: Perfluoroalkyl acids (PFAAs) are persistent and bioaccumulating compounds, which are spread all over the globe. We aimed to compare the PFAA concentrations in serum from pregnant women in five birth cohorts from four countries (Denmark, China, Norway, and Greenland). METHODS: Serum samples were obtained from the following five birth cohorts including a total of 4718 pregnant women: the Danish National Birth Cohort (DNBC, years 1996-2002, Denmark), the Aarhus Birth Cohort (ABC, years 2008-2013, Denmark), the Shanghai Birth Cohort (SBC, years 2013-2015, China), the Northern Norway Mother-Child Contaminant Cohort (MISA, years 2007-2009, Norway), and the Greenlandic Birth Cohort (ACCEPT, years 2010-2013, Greenland). The samples were analyzed using liquid chromatography triple-quadrupole mass spectrometry. To ensure comparability, all samples except for the MISA samples were measured in the same laboratory. We adjusted the PFAA concentrations for age and parity using analysis of covariance. RESULTS AND DISCUSSION: The mean of the summed concentrations of the seven most abundant PFAAs (∑PFAA) was 37ng/mL in the DNBC, 27ng/mL in the SBC, 21ng/mL in the ACCEPT, 14ng/mL in the MISA cohort, and 12ng/mL in the ABC. The DNBC concentration was highest presumably because these samples were taken in earlier years (i.e. 1996-2002) than the samples from the other cohorts (i.e. 2007-2015), and at a time when the production of PFAAs were at the highest. When excluding the DNBC samples, we found that the concentrations of all the perfluorinated sulfonic acids (PFSAs) and one of the four perfluorinated carboxylic acids (PFCAs) were highest in the Greenlandic women, whereas the other three PFCAs were highest in the Chinese women. CONCLUSION: The concentration and composition of serum PFAAs were similar for the Danish ABC women and the Norwegian MISA women but were otherwise different across the cohorts. The different exposure profiles might partly be related to differences in lifestyle and diet. As the concentrations and ... Article in Journal/Newspaper Greenland greenlandic Northern Norway Aarhus University: Research International Journal of Hygiene and Environmental Health 220 2 86 93 |
institution |
Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
China Denmark Exposure profiles Greenland Norway Perfluorinated compounds |
spellingShingle |
China Denmark Exposure profiles Greenland Norway Perfluorinated compounds Bjerregaard-Olesen, Christian Bossi, Rossana Liew, Zeyan Long, Manhai Bech, Bodil H Olsen, Jørn Henriksen, Tine B Berg, Vivian Nøst, Therese H Zhang, Jun J Bonefeld-Jørgensen, Eva C Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts |
topic_facet |
China Denmark Exposure profiles Greenland Norway Perfluorinated compounds |
description |
BACKGROUND: Perfluoroalkyl acids (PFAAs) are persistent and bioaccumulating compounds, which are spread all over the globe. We aimed to compare the PFAA concentrations in serum from pregnant women in five birth cohorts from four countries (Denmark, China, Norway, and Greenland). METHODS: Serum samples were obtained from the following five birth cohorts including a total of 4718 pregnant women: the Danish National Birth Cohort (DNBC, years 1996-2002, Denmark), the Aarhus Birth Cohort (ABC, years 2008-2013, Denmark), the Shanghai Birth Cohort (SBC, years 2013-2015, China), the Northern Norway Mother-Child Contaminant Cohort (MISA, years 2007-2009, Norway), and the Greenlandic Birth Cohort (ACCEPT, years 2010-2013, Greenland). The samples were analyzed using liquid chromatography triple-quadrupole mass spectrometry. To ensure comparability, all samples except for the MISA samples were measured in the same laboratory. We adjusted the PFAA concentrations for age and parity using analysis of covariance. RESULTS AND DISCUSSION: The mean of the summed concentrations of the seven most abundant PFAAs (∑PFAA) was 37ng/mL in the DNBC, 27ng/mL in the SBC, 21ng/mL in the ACCEPT, 14ng/mL in the MISA cohort, and 12ng/mL in the ABC. The DNBC concentration was highest presumably because these samples were taken in earlier years (i.e. 1996-2002) than the samples from the other cohorts (i.e. 2007-2015), and at a time when the production of PFAAs were at the highest. When excluding the DNBC samples, we found that the concentrations of all the perfluorinated sulfonic acids (PFSAs) and one of the four perfluorinated carboxylic acids (PFCAs) were highest in the Greenlandic women, whereas the other three PFCAs were highest in the Chinese women. CONCLUSION: The concentration and composition of serum PFAAs were similar for the Danish ABC women and the Norwegian MISA women but were otherwise different across the cohorts. The different exposure profiles might partly be related to differences in lifestyle and diet. As the concentrations and ... |
format |
Article in Journal/Newspaper |
author |
Bjerregaard-Olesen, Christian Bossi, Rossana Liew, Zeyan Long, Manhai Bech, Bodil H Olsen, Jørn Henriksen, Tine B Berg, Vivian Nøst, Therese H Zhang, Jun J Bonefeld-Jørgensen, Eva C |
author_facet |
Bjerregaard-Olesen, Christian Bossi, Rossana Liew, Zeyan Long, Manhai Bech, Bodil H Olsen, Jørn Henriksen, Tine B Berg, Vivian Nøst, Therese H Zhang, Jun J Bonefeld-Jørgensen, Eva C |
author_sort |
Bjerregaard-Olesen, Christian |
title |
Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts |
title_short |
Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts |
title_full |
Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts |
title_fullStr |
Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts |
title_full_unstemmed |
Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts |
title_sort |
maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts |
publishDate |
2017 |
url |
https://pure.au.dk/portal/da/publications/maternal-serum-concentrations-of-perfluoroalkyl-acids-in-five-international-birth-cohorts(a717df25-bd14-42fb-91cc-769c95d2a8c3).html https://doi.org/10.1016/j.ijheh.2016.12.005 |
genre |
Greenland greenlandic Northern Norway |
genre_facet |
Greenland greenlandic Northern Norway |
op_source |
Bjerregaard-Olesen , C , Bossi , R , Liew , Z , Long , M , Bech , B H , Olsen , J , Henriksen , T B , Berg , V , Nøst , T H , Zhang , J J & Bonefeld-Jørgensen , E C 2017 , ' Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts ' , International Journal of Hygiene and Environmental Health , vol. 220 , no. 2 Pt A , pp. 86–93 . https://doi.org/10.1016/j.ijheh.2016.12.005 |
op_relation |
https://pure.au.dk/portal/da/publications/maternal-serum-concentrations-of-perfluoroalkyl-acids-in-five-international-birth-cohorts(a717df25-bd14-42fb-91cc-769c95d2a8c3).html |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.ijheh.2016.12.005 |
container_title |
International Journal of Hygiene and Environmental Health |
container_volume |
220 |
container_issue |
2 |
container_start_page |
86 |
op_container_end_page |
93 |
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