Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy
Objective: Some studies of women with polycystic ovary syndrome (PCOS) report increased prevalence of hypertensive disorders in pregnancy, while others do not. Several of these studies do not control for obesity. We aimed to study whether PCOS is associated with hypertensive disorders in pregnancy a...
Published in: | Pregnancy Hypertension |
---|---|
Main Authors: | , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2018
|
Subjects: | |
Online Access: | https://pure.au.dk/portal/en/publications/a6fbbeaf-7f8f-4c34-9647-360c99d0020e https://doi.org/10.1016/j.preghy.2017.12.006 |
id |
ftuniaarhuspubl:oai:pure.atira.dk:publications/a6fbbeaf-7f8f-4c34-9647-360c99d0020e |
---|---|
record_format |
openpolar |
spelling |
ftuniaarhuspubl:oai:pure.atira.dk:publications/a6fbbeaf-7f8f-4c34-9647-360c99d0020e 2024-04-14T08:13:53+00:00 Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy Lønnebotn, Marianne Natvig, Gerd Karin Benediktsdóttir, Bryndís Burgess, John A Holm, Mathias Jógi, Rain Lindberg, Eva Macsali, Ferenc Schlünssen, Vivi Skulstad, Svein Magne Franklin, Karl A Vanky, Eszter Gòmez Real, Francisco 2018-01 https://pure.au.dk/portal/en/publications/a6fbbeaf-7f8f-4c34-9647-360c99d0020e https://doi.org/10.1016/j.preghy.2017.12.006 eng eng https://pure.au.dk/portal/en/publications/a6fbbeaf-7f8f-4c34-9647-360c99d0020e info:eu-repo/semantics/restrictedAccess Lønnebotn , M , Natvig , G K , Benediktsdóttir , B , Burgess , J A , Holm , M , Jógi , R , Lindberg , E , Macsali , F , Schlünssen , V , Skulstad , S M , Franklin , K A , Vanky , E & Gòmez Real , F 2018 , ' Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy ' , Pregnancy Hypertension , vol. 11 , pp. 32-37 . https://doi.org/10.1016/j.preghy.2017.12.006 Adult Blood Pressure Body Mass Index Chi-Square Distribution Cross-Sectional Studies Estonia/epidemiology Female Humans Hypertension Pregnancy-Induced/diagnosis Obesity/diagnosis Odds Ratio Polycystic Ovary Syndrome/diagnosis Pregnancy Prevalence Risk Assessment Risk Factors Scandinavian and Nordic Countries/epidemiology Surveys and Questionnaires Thinness/diagnosis article 2018 ftuniaarhuspubl https://doi.org/10.1016/j.preghy.2017.12.006 2024-03-21T15:28:17Z Objective: Some studies of women with polycystic ovary syndrome (PCOS) report increased prevalence of hypertensive disorders in pregnancy, while others do not. Several of these studies do not control for obesity. We aimed to study whether PCOS is associated with hypertensive disorders in pregnancy and whether it is dependent on body mass index (BMI). Study design: We present a cross-sectional analysis of 3732 women from Denmark, Estonia, Iceland, Norway and Sweden, born in 1945–72, who participated in the Respiratory Health In Northern Europe (RHINE) study and answered an extensive women's health questionnaire on menstruation, PCOS, infertility, pregnancy history and childbirth. The main outcome measurement was hypertensive disorders of pregnancy. We adjusted for smoking, age, infertility treatment and study center. Effect modification by BMI was assessed. Results: PCOS was related to hypertensive disorders in pregnancy with a relative risk (RR) of 1.62 (95% CI 1.09–2.42). This relationship was found among underweight women with a BMI of <18.5 kg/m 2 [RR = 5.2 (95% CI 1.66–16.5)] and obese women with a BMI of ≥30 kg/m 2 [RR = 2.36 (95% CI 1.29–4.31)], but not among normal-weight women, BMI 18.5–25 kg/m 2 [1.08 (0.53–2.20)], or overweight women, BMI 25–30 kg/m 2 [1.24 (0.50–3.08)] (p-interaction = 0.041). Conclusion: Polycystic ovary syndrome is associated with hypertensive disorders in pregnancy. This association only occurs among underweight and obese women and not among normal-weight and slightly overweight women. Article in Journal/Newspaper Iceland Aarhus University: Research Norway Pregnancy Hypertension 11 32 37 |
institution |
Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
Adult Blood Pressure Body Mass Index Chi-Square Distribution Cross-Sectional Studies Estonia/epidemiology Female Humans Hypertension Pregnancy-Induced/diagnosis Obesity/diagnosis Odds Ratio Polycystic Ovary Syndrome/diagnosis Pregnancy Prevalence Risk Assessment Risk Factors Scandinavian and Nordic Countries/epidemiology Surveys and Questionnaires Thinness/diagnosis |
spellingShingle |
Adult Blood Pressure Body Mass Index Chi-Square Distribution Cross-Sectional Studies Estonia/epidemiology Female Humans Hypertension Pregnancy-Induced/diagnosis Obesity/diagnosis Odds Ratio Polycystic Ovary Syndrome/diagnosis Pregnancy Prevalence Risk Assessment Risk Factors Scandinavian and Nordic Countries/epidemiology Surveys and Questionnaires Thinness/diagnosis Lønnebotn, Marianne Natvig, Gerd Karin Benediktsdóttir, Bryndís Burgess, John A Holm, Mathias Jógi, Rain Lindberg, Eva Macsali, Ferenc Schlünssen, Vivi Skulstad, Svein Magne Franklin, Karl A Vanky, Eszter Gòmez Real, Francisco Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy |
topic_facet |
Adult Blood Pressure Body Mass Index Chi-Square Distribution Cross-Sectional Studies Estonia/epidemiology Female Humans Hypertension Pregnancy-Induced/diagnosis Obesity/diagnosis Odds Ratio Polycystic Ovary Syndrome/diagnosis Pregnancy Prevalence Risk Assessment Risk Factors Scandinavian and Nordic Countries/epidemiology Surveys and Questionnaires Thinness/diagnosis |
description |
Objective: Some studies of women with polycystic ovary syndrome (PCOS) report increased prevalence of hypertensive disorders in pregnancy, while others do not. Several of these studies do not control for obesity. We aimed to study whether PCOS is associated with hypertensive disorders in pregnancy and whether it is dependent on body mass index (BMI). Study design: We present a cross-sectional analysis of 3732 women from Denmark, Estonia, Iceland, Norway and Sweden, born in 1945–72, who participated in the Respiratory Health In Northern Europe (RHINE) study and answered an extensive women's health questionnaire on menstruation, PCOS, infertility, pregnancy history and childbirth. The main outcome measurement was hypertensive disorders of pregnancy. We adjusted for smoking, age, infertility treatment and study center. Effect modification by BMI was assessed. Results: PCOS was related to hypertensive disorders in pregnancy with a relative risk (RR) of 1.62 (95% CI 1.09–2.42). This relationship was found among underweight women with a BMI of <18.5 kg/m 2 [RR = 5.2 (95% CI 1.66–16.5)] and obese women with a BMI of ≥30 kg/m 2 [RR = 2.36 (95% CI 1.29–4.31)], but not among normal-weight women, BMI 18.5–25 kg/m 2 [1.08 (0.53–2.20)], or overweight women, BMI 25–30 kg/m 2 [1.24 (0.50–3.08)] (p-interaction = 0.041). Conclusion: Polycystic ovary syndrome is associated with hypertensive disorders in pregnancy. This association only occurs among underweight and obese women and not among normal-weight and slightly overweight women. |
format |
Article in Journal/Newspaper |
author |
Lønnebotn, Marianne Natvig, Gerd Karin Benediktsdóttir, Bryndís Burgess, John A Holm, Mathias Jógi, Rain Lindberg, Eva Macsali, Ferenc Schlünssen, Vivi Skulstad, Svein Magne Franklin, Karl A Vanky, Eszter Gòmez Real, Francisco |
author_facet |
Lønnebotn, Marianne Natvig, Gerd Karin Benediktsdóttir, Bryndís Burgess, John A Holm, Mathias Jógi, Rain Lindberg, Eva Macsali, Ferenc Schlünssen, Vivi Skulstad, Svein Magne Franklin, Karl A Vanky, Eszter Gòmez Real, Francisco |
author_sort |
Lønnebotn, Marianne |
title |
Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy |
title_short |
Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy |
title_full |
Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy |
title_fullStr |
Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy |
title_full_unstemmed |
Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy |
title_sort |
polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy |
publishDate |
2018 |
url |
https://pure.au.dk/portal/en/publications/a6fbbeaf-7f8f-4c34-9647-360c99d0020e https://doi.org/10.1016/j.preghy.2017.12.006 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Lønnebotn , M , Natvig , G K , Benediktsdóttir , B , Burgess , J A , Holm , M , Jógi , R , Lindberg , E , Macsali , F , Schlünssen , V , Skulstad , S M , Franklin , K A , Vanky , E & Gòmez Real , F 2018 , ' Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy ' , Pregnancy Hypertension , vol. 11 , pp. 32-37 . https://doi.org/10.1016/j.preghy.2017.12.006 |
op_relation |
https://pure.au.dk/portal/en/publications/a6fbbeaf-7f8f-4c34-9647-360c99d0020e |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.preghy.2017.12.006 |
container_title |
Pregnancy Hypertension |
container_volume |
11 |
container_start_page |
32 |
op_container_end_page |
37 |
_version_ |
1796311973484298240 |