Hospital admission for neurologic disorders among 5-year survivors of noncentral nervous system tumors in childhood:A cohort study within the Adult Life after Childhood Cancer in Scandinavia study
Large, comprehensive studies of the risk for neurologic disorders among long-term survivors of noncentral nervous system (CNS) childhood cancers are lacking. Thus, the aim of our study was to assess the lifetime risk of Nordic non-CNS childhood cancer survivors for neurologic disorders. We identifie...
Published in: | International Journal of Cancer |
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Format: | Article in Journal/Newspaper |
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2020
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Online Access: | https://pure.au.dk/portal/en/publications/9dc1f734-0e82-4f26-870d-ab81e25e2089 https://doi.org/10.1002/ijc.32341 |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/9dc1f734-0e82-4f26-870d-ab81e25e2089 2024-06-23T07:54:06+00:00 Hospital admission for neurologic disorders among 5-year survivors of noncentral nervous system tumors in childhood:A cohort study within the Adult Life after Childhood Cancer in Scandinavia study Kenborg, Line Linnet, Karen M de Fine Licht, Sofie Bautz, Andrea Holmqvist, Anna S Tryggvadottir, Laufey Madanat-Harjuoja, Laura M Stovall, Marilyn Heilmann, Carsten Albieri, Vanna Hasle, Henrik Winther, Jeanette F 2020-02 https://pure.au.dk/portal/en/publications/9dc1f734-0e82-4f26-870d-ab81e25e2089 https://doi.org/10.1002/ijc.32341 eng eng https://pure.au.dk/portal/en/publications/9dc1f734-0e82-4f26-870d-ab81e25e2089 info:eu-repo/semantics/restrictedAccess Kenborg , L , Linnet , K M , de Fine Licht , S , Bautz , A , Holmqvist , A S , Tryggvadottir , L , Madanat-Harjuoja , L M , Stovall , M , Heilmann , C , Albieri , V , Hasle , H , Winther , J F & ALiCCS Study Group 2020 , ' Hospital admission for neurologic disorders among 5-year survivors of noncentral nervous system tumors in childhood : A cohort study within the Adult Life after Childhood Cancer in Scandinavia study ' , International Journal of Cancer , vol. 146 , no. 3 , pp. 819-828 . https://doi.org/10.1002/ijc.32341 childhood cancer cohort study late effects neurologic disorders article 2020 ftuniaarhuspubl https://doi.org/10.1002/ijc.32341 2024-06-04T14:24:06Z Large, comprehensive studies of the risk for neurologic disorders among long-term survivors of noncentral nervous system (CNS) childhood cancers are lacking. Thus, the aim of our study was to assess the lifetime risk of Nordic non-CNS childhood cancer survivors for neurologic disorders. We identified 15,967 5-year survivors of non-CNS childhood cancer diagnosed in Denmark, Iceland, Finland and Sweden in 1943-2008, and 151,118 matched population comparison subjects. In-patient discharge diagnoses of neurologic disorders were used to calculate relative risks (RRs) and absolute excess risks (AERs). A neurologic disorder was diagnosed in 755 of the survivors while 370 were expected, yielding a RR of 2.0 (95% confidence interval (CI) 1.9-2.2). The highest risks were found among survivors of neuroblastoma (4.1; 95% CI 3.2-5.3) and leukemia (2.8; 95% CI 2.4-3.2). The AER decreased from 331 (278-383) excess neurologic disorders per 100,000 person-years 5-9 years after diagnosis to 82 (46-118) ≥ 20 years after diagnosis. Epilepsy was the most common diagnosis (n = 229, 1.4% of all survivors), and significantly increased risks were seen among survivors of eight out of 12 types of childhood cancer. Survivors of neuroblastoma had remarkably high risks (RR ≥ 10) for hospitalization for paralytic syndromes and hydrocephalus, while survivors of leukemia had additional high risks for dementia and encephalopathy. In conclusion, survivors of non-CNS childhood cancer are at high risk for neurologic disorders, especially within the first decade after diagnosis. Therefore, intensive follow-up to identify those who require close management is needed. Article in Journal/Newspaper Iceland Aarhus University: Research International Journal of Cancer 146 3 819 828 |
institution |
Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
childhood cancer cohort study late effects neurologic disorders |
spellingShingle |
childhood cancer cohort study late effects neurologic disorders Kenborg, Line Linnet, Karen M de Fine Licht, Sofie Bautz, Andrea Holmqvist, Anna S Tryggvadottir, Laufey Madanat-Harjuoja, Laura M Stovall, Marilyn Heilmann, Carsten Albieri, Vanna Hasle, Henrik Winther, Jeanette F Hospital admission for neurologic disorders among 5-year survivors of noncentral nervous system tumors in childhood:A cohort study within the Adult Life after Childhood Cancer in Scandinavia study |
topic_facet |
childhood cancer cohort study late effects neurologic disorders |
description |
Large, comprehensive studies of the risk for neurologic disorders among long-term survivors of noncentral nervous system (CNS) childhood cancers are lacking. Thus, the aim of our study was to assess the lifetime risk of Nordic non-CNS childhood cancer survivors for neurologic disorders. We identified 15,967 5-year survivors of non-CNS childhood cancer diagnosed in Denmark, Iceland, Finland and Sweden in 1943-2008, and 151,118 matched population comparison subjects. In-patient discharge diagnoses of neurologic disorders were used to calculate relative risks (RRs) and absolute excess risks (AERs). A neurologic disorder was diagnosed in 755 of the survivors while 370 were expected, yielding a RR of 2.0 (95% confidence interval (CI) 1.9-2.2). The highest risks were found among survivors of neuroblastoma (4.1; 95% CI 3.2-5.3) and leukemia (2.8; 95% CI 2.4-3.2). The AER decreased from 331 (278-383) excess neurologic disorders per 100,000 person-years 5-9 years after diagnosis to 82 (46-118) ≥ 20 years after diagnosis. Epilepsy was the most common diagnosis (n = 229, 1.4% of all survivors), and significantly increased risks were seen among survivors of eight out of 12 types of childhood cancer. Survivors of neuroblastoma had remarkably high risks (RR ≥ 10) for hospitalization for paralytic syndromes and hydrocephalus, while survivors of leukemia had additional high risks for dementia and encephalopathy. In conclusion, survivors of non-CNS childhood cancer are at high risk for neurologic disorders, especially within the first decade after diagnosis. Therefore, intensive follow-up to identify those who require close management is needed. |
format |
Article in Journal/Newspaper |
author |
Kenborg, Line Linnet, Karen M de Fine Licht, Sofie Bautz, Andrea Holmqvist, Anna S Tryggvadottir, Laufey Madanat-Harjuoja, Laura M Stovall, Marilyn Heilmann, Carsten Albieri, Vanna Hasle, Henrik Winther, Jeanette F |
author_facet |
Kenborg, Line Linnet, Karen M de Fine Licht, Sofie Bautz, Andrea Holmqvist, Anna S Tryggvadottir, Laufey Madanat-Harjuoja, Laura M Stovall, Marilyn Heilmann, Carsten Albieri, Vanna Hasle, Henrik Winther, Jeanette F |
author_sort |
Kenborg, Line |
title |
Hospital admission for neurologic disorders among 5-year survivors of noncentral nervous system tumors in childhood:A cohort study within the Adult Life after Childhood Cancer in Scandinavia study |
title_short |
Hospital admission for neurologic disorders among 5-year survivors of noncentral nervous system tumors in childhood:A cohort study within the Adult Life after Childhood Cancer in Scandinavia study |
title_full |
Hospital admission for neurologic disorders among 5-year survivors of noncentral nervous system tumors in childhood:A cohort study within the Adult Life after Childhood Cancer in Scandinavia study |
title_fullStr |
Hospital admission for neurologic disorders among 5-year survivors of noncentral nervous system tumors in childhood:A cohort study within the Adult Life after Childhood Cancer in Scandinavia study |
title_full_unstemmed |
Hospital admission for neurologic disorders among 5-year survivors of noncentral nervous system tumors in childhood:A cohort study within the Adult Life after Childhood Cancer in Scandinavia study |
title_sort |
hospital admission for neurologic disorders among 5-year survivors of noncentral nervous system tumors in childhood:a cohort study within the adult life after childhood cancer in scandinavia study |
publishDate |
2020 |
url |
https://pure.au.dk/portal/en/publications/9dc1f734-0e82-4f26-870d-ab81e25e2089 https://doi.org/10.1002/ijc.32341 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Kenborg , L , Linnet , K M , de Fine Licht , S , Bautz , A , Holmqvist , A S , Tryggvadottir , L , Madanat-Harjuoja , L M , Stovall , M , Heilmann , C , Albieri , V , Hasle , H , Winther , J F & ALiCCS Study Group 2020 , ' Hospital admission for neurologic disorders among 5-year survivors of noncentral nervous system tumors in childhood : A cohort study within the Adult Life after Childhood Cancer in Scandinavia study ' , International Journal of Cancer , vol. 146 , no. 3 , pp. 819-828 . https://doi.org/10.1002/ijc.32341 |
op_relation |
https://pure.au.dk/portal/en/publications/9dc1f734-0e82-4f26-870d-ab81e25e2089 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1002/ijc.32341 |
container_title |
International Journal of Cancer |
container_volume |
146 |
container_issue |
3 |
container_start_page |
819 |
op_container_end_page |
828 |
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1802646069872427008 |