Potential natural immunization against atherosclerosis in hibernating bears
Brown bears (Ursus arctos) hibernate for 5–6 months during winter, but despite kidney insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associat...
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ftuniaarhuspubl:oai:pure.atira.dk:publications/98232e11-1de4-4ce1-8beb-52d65458f997 2023-07-16T04:01:13+02:00 Potential natural immunization against atherosclerosis in hibernating bears Samal, Shailesh Kumar Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegård, Johan 2021-12 https://pure.au.dk/portal/da/publications/potential-natural-immunization-against-atherosclerosis-in-hibernating-bears(98232e11-1de4-4ce1-8beb-52d65458f997).html https://doi.org/10.1038/s41598-021-91679-1 http://www.scopus.com/inward/record.url?scp=85107396704&partnerID=8YFLogxK eng eng info:eu-repo/semantics/openAccess Samal , S K , Fröbert , O , Kindberg , J , Stenvinkel , P & Frostegård , J 2021 , ' Potential natural immunization against atherosclerosis in hibernating bears ' , Scientific Reports , vol. 11 , no. 1 , 12120 . https://doi.org/10.1038/s41598-021-91679-1 article 2021 ftuniaarhuspubl https://doi.org/10.1038/s41598-021-91679-1 2023-06-28T22:59:09Z Brown bears (Ursus arctos) hibernate for 5–6 months during winter, but despite kidney insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associated with less atherosclerosis, CVD and mortality in uremia in humans and have anti-inflammatory and other potentially protective properties. PC but not MDA is exposed on different types of microorganisms. We determine anti-PC and anti-MDA in brown bears in summer and winter. Paired serum samples from 12 free ranging Swedish brown bears were collected during hibernation in winter and during active state in summer and analyzed for IgM, IgG, IgG1/2 and IgA anti-PC and anti-MDA by enzyme linked immunosorbent assay (ELISA). When determined as arbitrary units (median set at 100 for summer samples), significantly raised levels were observed in winter for anti-PC subclasses and isotypes, and for IgA anti-PC the difference was striking; 100 IQR (85.9–107.9) vs 782.3, IQR (422.8–1586.0; p < 0.001). In contrast, subclasses and isotypes of anti-MDA were significantly lower in winter except IgA anti-MDA, which was not detectable. Anti-PCs are significantly raised during hibernation in brown bears; especially IgA anti-PC was strikingly high. In contrast, anti-MDA titers was decreased during hibernation. Our observation may represent natural immunization with microorganisms during a vulnerable period and could have therapeutic implications for prevention of atherosclerosis. Article in Journal/Newspaper Ursus arctos Aarhus University: Research Scientific Reports 11 1 |
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Open Polar |
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Aarhus University: Research |
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ftuniaarhuspubl |
language |
English |
description |
Brown bears (Ursus arctos) hibernate for 5–6 months during winter, but despite kidney insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associated with less atherosclerosis, CVD and mortality in uremia in humans and have anti-inflammatory and other potentially protective properties. PC but not MDA is exposed on different types of microorganisms. We determine anti-PC and anti-MDA in brown bears in summer and winter. Paired serum samples from 12 free ranging Swedish brown bears were collected during hibernation in winter and during active state in summer and analyzed for IgM, IgG, IgG1/2 and IgA anti-PC and anti-MDA by enzyme linked immunosorbent assay (ELISA). When determined as arbitrary units (median set at 100 for summer samples), significantly raised levels were observed in winter for anti-PC subclasses and isotypes, and for IgA anti-PC the difference was striking; 100 IQR (85.9–107.9) vs 782.3, IQR (422.8–1586.0; p < 0.001). In contrast, subclasses and isotypes of anti-MDA were significantly lower in winter except IgA anti-MDA, which was not detectable. Anti-PCs are significantly raised during hibernation in brown bears; especially IgA anti-PC was strikingly high. In contrast, anti-MDA titers was decreased during hibernation. Our observation may represent natural immunization with microorganisms during a vulnerable period and could have therapeutic implications for prevention of atherosclerosis. |
format |
Article in Journal/Newspaper |
author |
Samal, Shailesh Kumar Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegård, Johan |
spellingShingle |
Samal, Shailesh Kumar Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegård, Johan Potential natural immunization against atherosclerosis in hibernating bears |
author_facet |
Samal, Shailesh Kumar Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegård, Johan |
author_sort |
Samal, Shailesh Kumar |
title |
Potential natural immunization against atherosclerosis in hibernating bears |
title_short |
Potential natural immunization against atherosclerosis in hibernating bears |
title_full |
Potential natural immunization against atherosclerosis in hibernating bears |
title_fullStr |
Potential natural immunization against atherosclerosis in hibernating bears |
title_full_unstemmed |
Potential natural immunization against atherosclerosis in hibernating bears |
title_sort |
potential natural immunization against atherosclerosis in hibernating bears |
publishDate |
2021 |
url |
https://pure.au.dk/portal/da/publications/potential-natural-immunization-against-atherosclerosis-in-hibernating-bears(98232e11-1de4-4ce1-8beb-52d65458f997).html https://doi.org/10.1038/s41598-021-91679-1 http://www.scopus.com/inward/record.url?scp=85107396704&partnerID=8YFLogxK |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
Samal , S K , Fröbert , O , Kindberg , J , Stenvinkel , P & Frostegård , J 2021 , ' Potential natural immunization against atherosclerosis in hibernating bears ' , Scientific Reports , vol. 11 , no. 1 , 12120 . https://doi.org/10.1038/s41598-021-91679-1 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/s41598-021-91679-1 |
container_title |
Scientific Reports |
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11 |
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1 |
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1771550829716701184 |