Regulation of blood oxygen transport in hibernating mammals
Along with the periodic reductions in O-2 requirements of mammalian hibernators during winter, the O-2 affinity of the blood of mammalian hibernators is seasonally regulated to help match O-2 supply to consumption, contributing to limit tissue oxidative stress, particularly at arousals. Specifically...
Published in: | Journal of Comparative Physiology B |
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2017
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ftuniaarhuspubl:oai:pure.atira.dk:publications/9787f7a7-2cac-409f-ab63-99667cb21342 2023-05-15T18:42:13+02:00 Regulation of blood oxygen transport in hibernating mammals Revsbech, Inge G. Fago, Angela 2017-07 https://pure.au.dk/portal/da/publications/regulation-of-blood-oxygen-transport-in-hibernating-mammals(9787f7a7-2cac-409f-ab63-99667cb21342).html https://doi.org/10.1007/s00360-017-1085-6 eng eng info:eu-repo/semantics/restrictedAccess Revsbech , I G & Fago , A 2017 , ' Regulation of blood oxygen transport in hibernating mammals ' , Journal of Comparative Physiology B: Biochemical, Systems, and Environmental Physiology , vol. 187 , no. 5-6 , pp. 847-856 . https://doi.org/10.1007/s00360-017-1085-6 2,3-Diphosphoglycerate Allosteric effects Enthalpy of oxygenation Metabolic depression Hemoglobin-oxygen affinity Hibernation BEAR URSUS-ARCTOS LOWLAND DEER MICE GROUND-SQUIRRELS ORGANIC-PHOSPHATES HEMOGLOBIN-FUNCTION BODY-TEMPERATURE BROWN BEARS RESPIRATORY PROPERTIES METABOLIC SUPPRESSION ALLOSTERIC REGULATION article 2017 ftuniaarhuspubl https://doi.org/10.1007/s00360-017-1085-6 2020-07-18T21:58:13Z Along with the periodic reductions in O-2 requirements of mammalian hibernators during winter, the O-2 affinity of the blood of mammalian hibernators is seasonally regulated to help match O-2 supply to consumption, contributing to limit tissue oxidative stress, particularly at arousals. Specifically, mammalian hibernators consistently show an overall increase in the blood-O-2 affinity, which causes a decreased O-2 unloading to tissues, while having similar or lower tissue O-2 tensions during hibernation. This overview explores how the decreased body temperature and concentration of red blood cell 2,3-diphosphoglycerate (DPG) that occur in hibernation contribute separately or in combination to the concurrent increase in the O-2 affinity of the hemoglobin, the O-2 carrier protein of the blood. Most mammalian hemoglobins are responsive to changes in DPG concentrations, including that of the hibernating brown bear, although the smaller hibernators, such as golden-mantled ground squirrel, chipmunks, and dormice, have hemoglobins with low sensitivity to DPG. While the effect of DPG on oxygenation may vary, the decrease in body temperature invariably increases hemoglobin's O-2 affinity in all hibernating species. However, the temperature sensitivity of hemoglobin oxygenation is low in hibernators compared to human, apparently due in part to endothermic allosteric quaternary transition in ground squirrels and dissociation of chloride ions in brown bears. A low heat of blood oxygenation in temporal heterotherms, like hibernators, may thus contribute to reduce heat loss, as found in regional heterotherms, like polar mammals, although the significance would be low in winter hibernation. Article in Journal/Newspaper Ursus arctos Aarhus University: Research Journal of Comparative Physiology B 187 5-6 847 856 |
institution |
Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
2,3-Diphosphoglycerate Allosteric effects Enthalpy of oxygenation Metabolic depression Hemoglobin-oxygen affinity Hibernation BEAR URSUS-ARCTOS LOWLAND DEER MICE GROUND-SQUIRRELS ORGANIC-PHOSPHATES HEMOGLOBIN-FUNCTION BODY-TEMPERATURE BROWN BEARS RESPIRATORY PROPERTIES METABOLIC SUPPRESSION ALLOSTERIC REGULATION |
spellingShingle |
2,3-Diphosphoglycerate Allosteric effects Enthalpy of oxygenation Metabolic depression Hemoglobin-oxygen affinity Hibernation BEAR URSUS-ARCTOS LOWLAND DEER MICE GROUND-SQUIRRELS ORGANIC-PHOSPHATES HEMOGLOBIN-FUNCTION BODY-TEMPERATURE BROWN BEARS RESPIRATORY PROPERTIES METABOLIC SUPPRESSION ALLOSTERIC REGULATION Revsbech, Inge G. Fago, Angela Regulation of blood oxygen transport in hibernating mammals |
topic_facet |
2,3-Diphosphoglycerate Allosteric effects Enthalpy of oxygenation Metabolic depression Hemoglobin-oxygen affinity Hibernation BEAR URSUS-ARCTOS LOWLAND DEER MICE GROUND-SQUIRRELS ORGANIC-PHOSPHATES HEMOGLOBIN-FUNCTION BODY-TEMPERATURE BROWN BEARS RESPIRATORY PROPERTIES METABOLIC SUPPRESSION ALLOSTERIC REGULATION |
description |
Along with the periodic reductions in O-2 requirements of mammalian hibernators during winter, the O-2 affinity of the blood of mammalian hibernators is seasonally regulated to help match O-2 supply to consumption, contributing to limit tissue oxidative stress, particularly at arousals. Specifically, mammalian hibernators consistently show an overall increase in the blood-O-2 affinity, which causes a decreased O-2 unloading to tissues, while having similar or lower tissue O-2 tensions during hibernation. This overview explores how the decreased body temperature and concentration of red blood cell 2,3-diphosphoglycerate (DPG) that occur in hibernation contribute separately or in combination to the concurrent increase in the O-2 affinity of the hemoglobin, the O-2 carrier protein of the blood. Most mammalian hemoglobins are responsive to changes in DPG concentrations, including that of the hibernating brown bear, although the smaller hibernators, such as golden-mantled ground squirrel, chipmunks, and dormice, have hemoglobins with low sensitivity to DPG. While the effect of DPG on oxygenation may vary, the decrease in body temperature invariably increases hemoglobin's O-2 affinity in all hibernating species. However, the temperature sensitivity of hemoglobin oxygenation is low in hibernators compared to human, apparently due in part to endothermic allosteric quaternary transition in ground squirrels and dissociation of chloride ions in brown bears. A low heat of blood oxygenation in temporal heterotherms, like hibernators, may thus contribute to reduce heat loss, as found in regional heterotherms, like polar mammals, although the significance would be low in winter hibernation. |
format |
Article in Journal/Newspaper |
author |
Revsbech, Inge G. Fago, Angela |
author_facet |
Revsbech, Inge G. Fago, Angela |
author_sort |
Revsbech, Inge G. |
title |
Regulation of blood oxygen transport in hibernating mammals |
title_short |
Regulation of blood oxygen transport in hibernating mammals |
title_full |
Regulation of blood oxygen transport in hibernating mammals |
title_fullStr |
Regulation of blood oxygen transport in hibernating mammals |
title_full_unstemmed |
Regulation of blood oxygen transport in hibernating mammals |
title_sort |
regulation of blood oxygen transport in hibernating mammals |
publishDate |
2017 |
url |
https://pure.au.dk/portal/da/publications/regulation-of-blood-oxygen-transport-in-hibernating-mammals(9787f7a7-2cac-409f-ab63-99667cb21342).html https://doi.org/10.1007/s00360-017-1085-6 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
Revsbech , I G & Fago , A 2017 , ' Regulation of blood oxygen transport in hibernating mammals ' , Journal of Comparative Physiology B: Biochemical, Systems, and Environmental Physiology , vol. 187 , no. 5-6 , pp. 847-856 . https://doi.org/10.1007/s00360-017-1085-6 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1007/s00360-017-1085-6 |
container_title |
Journal of Comparative Physiology B |
container_volume |
187 |
container_issue |
5-6 |
container_start_page |
847 |
op_container_end_page |
856 |
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1766231835385266176 |