Late and very late mortality in 5-year survivors of childhood cancer:changing pattern over four decades--experience from the Nordic countries
Long-term survivors of childhood cancer suffer from a higher mortality than the general population. Here we evaluate late and very late mortality, and patterns of causes of death, in 5-year survivors after childhood and adolescent cancer in cases diagnosed during four decades in the five Nordic coun...
Published in: | International Journal of Cancer |
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Online Access: | https://pure.au.dk/portal/en/publications/939b8eb6-1086-4650-be4d-790356220f22 https://doi.org/10.1002/ijc.27393 |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/939b8eb6-1086-4650-be4d-790356220f22 2024-06-23T07:54:00+00:00 Late and very late mortality in 5-year survivors of childhood cancer:changing pattern over four decades--experience from the Nordic countries 2012-10-01 https://pure.au.dk/portal/en/publications/939b8eb6-1086-4650-be4d-790356220f22 https://doi.org/10.1002/ijc.27393 eng eng https://pure.au.dk/portal/en/publications/939b8eb6-1086-4650-be4d-790356220f22 info:eu-repo/semantics/restrictedAccess Association of the Nordic Cancer Registries 2012 , ' Late and very late mortality in 5-year survivors of childhood cancer : changing pattern over four decades--experience from the Nordic countries ' , International Journal of Cancer , vol. 131 , no. 7 , pp. 1659-66 . https://doi.org/10.1002/ijc.27393 Adolescent Adult Age Factors Cause of Death Child Preschool Cohort Studies Female Finland/epidemiology Follow-Up Studies Humans Iceland/epidemiology Infant Newborn Male Neoplasms/epidemiology Scandinavian and Nordic Countries/epidemiology Survivors Time Factors Young Adult article 2012 ftuniaarhuspubl https://doi.org/10.1002/ijc.27393 2024-06-04T14:24:06Z Long-term survivors of childhood cancer suffer from a higher mortality than the general population. Here we evaluate late and very late mortality, and patterns of causes of death, in 5-year survivors after childhood and adolescent cancer in cases diagnosed during four decades in the five Nordic countries. The study is population-based and uses data of the nationwide cancer registries and the cause of death registers. There were in all 37,515 incident cases, diagnosed with cancer before the age of 20 years, between 1960 and 1999. The 5-year survivor cohort used in the mortality analyses consisted of 21,984 patients who were followed up for vital status until December 31, 2005 (Norway, Sweden) or 2006 (Denmark, Finland, Iceland). At the latest follow-up, 2,324 patients were dead. The overall standardized mortality ratio was 8.3 and the absolute excess risk was 6.2 per 1,000 person-years. The pattern of causes of death varied markedly between different groups of primary cancer diagnosis, and was highly dependent on time passed since diagnosis. With shorter follow-up the mortality was mainly due to primary cancer, while with longer follow-up, mortality due to second cancer and noncancer causes became more prominent. Mortality between 5 and 10 years after diagnosis continued to decrease in patients treated during the most recent period of time, 1990-1999, compared to previous periods, while mortality after 10 years changed very little with time period. We conclude that improvement of definite survival demands not only reducing early but also late and very late mortality. Article in Journal/Newspaper Iceland Aarhus University: Research Norway International Journal of Cancer 131 7 1659 1666 |
institution |
Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
Adolescent Adult Age Factors Cause of Death Child Preschool Cohort Studies Female Finland/epidemiology Follow-Up Studies Humans Iceland/epidemiology Infant Newborn Male Neoplasms/epidemiology Scandinavian and Nordic Countries/epidemiology Survivors Time Factors Young Adult |
spellingShingle |
Adolescent Adult Age Factors Cause of Death Child Preschool Cohort Studies Female Finland/epidemiology Follow-Up Studies Humans Iceland/epidemiology Infant Newborn Male Neoplasms/epidemiology Scandinavian and Nordic Countries/epidemiology Survivors Time Factors Young Adult Late and very late mortality in 5-year survivors of childhood cancer:changing pattern over four decades--experience from the Nordic countries |
topic_facet |
Adolescent Adult Age Factors Cause of Death Child Preschool Cohort Studies Female Finland/epidemiology Follow-Up Studies Humans Iceland/epidemiology Infant Newborn Male Neoplasms/epidemiology Scandinavian and Nordic Countries/epidemiology Survivors Time Factors Young Adult |
description |
Long-term survivors of childhood cancer suffer from a higher mortality than the general population. Here we evaluate late and very late mortality, and patterns of causes of death, in 5-year survivors after childhood and adolescent cancer in cases diagnosed during four decades in the five Nordic countries. The study is population-based and uses data of the nationwide cancer registries and the cause of death registers. There were in all 37,515 incident cases, diagnosed with cancer before the age of 20 years, between 1960 and 1999. The 5-year survivor cohort used in the mortality analyses consisted of 21,984 patients who were followed up for vital status until December 31, 2005 (Norway, Sweden) or 2006 (Denmark, Finland, Iceland). At the latest follow-up, 2,324 patients were dead. The overall standardized mortality ratio was 8.3 and the absolute excess risk was 6.2 per 1,000 person-years. The pattern of causes of death varied markedly between different groups of primary cancer diagnosis, and was highly dependent on time passed since diagnosis. With shorter follow-up the mortality was mainly due to primary cancer, while with longer follow-up, mortality due to second cancer and noncancer causes became more prominent. Mortality between 5 and 10 years after diagnosis continued to decrease in patients treated during the most recent period of time, 1990-1999, compared to previous periods, while mortality after 10 years changed very little with time period. We conclude that improvement of definite survival demands not only reducing early but also late and very late mortality. |
format |
Article in Journal/Newspaper |
title |
Late and very late mortality in 5-year survivors of childhood cancer:changing pattern over four decades--experience from the Nordic countries |
title_short |
Late and very late mortality in 5-year survivors of childhood cancer:changing pattern over four decades--experience from the Nordic countries |
title_full |
Late and very late mortality in 5-year survivors of childhood cancer:changing pattern over four decades--experience from the Nordic countries |
title_fullStr |
Late and very late mortality in 5-year survivors of childhood cancer:changing pattern over four decades--experience from the Nordic countries |
title_full_unstemmed |
Late and very late mortality in 5-year survivors of childhood cancer:changing pattern over four decades--experience from the Nordic countries |
title_sort |
late and very late mortality in 5-year survivors of childhood cancer:changing pattern over four decades--experience from the nordic countries |
publishDate |
2012 |
url |
https://pure.au.dk/portal/en/publications/939b8eb6-1086-4650-be4d-790356220f22 https://doi.org/10.1002/ijc.27393 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Association of the Nordic Cancer Registries 2012 , ' Late and very late mortality in 5-year survivors of childhood cancer : changing pattern over four decades--experience from the Nordic countries ' , International Journal of Cancer , vol. 131 , no. 7 , pp. 1659-66 . https://doi.org/10.1002/ijc.27393 |
op_relation |
https://pure.au.dk/portal/en/publications/939b8eb6-1086-4650-be4d-790356220f22 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1002/ijc.27393 |
container_title |
International Journal of Cancer |
container_volume |
131 |
container_issue |
7 |
container_start_page |
1659 |
op_container_end_page |
1666 |
_version_ |
1802645929576103936 |