Body mass index standard deviation score and obesity in children with type 1 diabetes in the Nordic countries. HbA1c and other predictors of increasing BMISDS
BACKGROUND: Intensified insulin therapy may increase body weight and cause obesity. This study compared body mass index standard deviation score (BMISDS) and obesity rate in children with type 1 diabetes (T1D) in Denmark, Iceland, Norway and Sweden, and uncovered predictors for increasing BMISDS. ME...
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2018
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Online Access: | https://pure.au.dk/portal/en/publications/8feaa969-c2ef-4677-8cee-55dc0db619cc https://doi.org/10.1111/pedi.12693 |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/8feaa969-c2ef-4677-8cee-55dc0db619cc 2024-04-28T08:26:11+00:00 Body mass index standard deviation score and obesity in children with type 1 diabetes in the Nordic countries. HbA1c and other predictors of increasing BMISDS Birkebaek, N H Kahlert, J Bjarnason, R Drivvoll, A K Johansen, A Konradsdottir, E Pundziute-Lyckå, A Samuelsson, U Skrivarhaug, T Svensson, J 2018-11 https://pure.au.dk/portal/en/publications/8feaa969-c2ef-4677-8cee-55dc0db619cc https://doi.org/10.1111/pedi.12693 eng eng https://pure.au.dk/portal/en/publications/8feaa969-c2ef-4677-8cee-55dc0db619cc info:eu-repo/semantics/restrictedAccess Birkebaek , N H , Kahlert , J , Bjarnason , R , Drivvoll , A K , Johansen , A , Konradsdottir , E , Pundziute-Lyckå , A , Samuelsson , U , Skrivarhaug , T , Svensson , J & Nordic Childhood Diabetes Registry Study Group, NordicDiabKids 2018 , ' Body mass index standard deviation score and obesity in children with type 1 diabetes in the Nordic countries. HbA1c and other predictors of increasing BMISDS ' , Pediatric Diabetes , vol. 19 , no. 7 , pp. 1198-1205 . https://doi.org/10.1111/pedi.12693 BMISDS HbA Nordic countries insulin therapy modality obesity risk factors article 2018 ftuniaarhuspubl https://doi.org/10.1111/pedi.12693 2024-04-04T16:53:37Z BACKGROUND: Intensified insulin therapy may increase body weight and cause obesity. This study compared body mass index standard deviation score (BMISDS) and obesity rate in children with type 1 diabetes (T1D) in Denmark, Iceland, Norway and Sweden, and uncovered predictors for increasing BMISDS. METHODS: Data registered in the Nordic national childhood diabetes databases during the period 2008-2012 on children below 15 years with T1D for more than 3 months were compiled, including information on gender, age, diabetes duration, hemoglobin A1c (HbA1c ), insulin dose, severe hypoglycemia (SH), treatment modality, height and weight. The Swedish reference chart for BMI was used for calculating BMISDS. RESULTS: Totally, 11 025 children (48% females) (30 994 registrations) were included. Medians by the last recorded examination were: age, 13.5 years; diabetes duration, 4.3 years; HbA1c , 7.9% (63 mmol/mol); insulin dose, 0.8 IU/kg/d and BMISDS, 0.70. Obesity rate was 18.5%. Adjusted mean BMISDS (BMISDS adj) was inversely related to HbA1c and directly to diabetes duration. Higher BMISDS adj was found in those with an insulin dose above 0.6 IU/kg/d, and in girls above 10 years. Pump users had higher BMISDS adj than pen users, and patients with registered SH had higher BMISDS adj than patients without SH (both P < .001). CONCLUSION: Obesity rate in children with T1D in the Nordic countries is high, however, with country differences. Low HbA1c , long diabetes duration, higher insulin dose, pump treatment and experiencing a SH predicted higher BMISDS. Diabetes caregivers should balance the risk of obesity and the benefit of a very low HbA1c. Article in Journal/Newspaper Iceland Aarhus University: Research Pediatric Diabetes 19 7 1198 1205 |
institution |
Open Polar |
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Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
BMISDS HbA Nordic countries insulin therapy modality obesity risk factors |
spellingShingle |
BMISDS HbA Nordic countries insulin therapy modality obesity risk factors Birkebaek, N H Kahlert, J Bjarnason, R Drivvoll, A K Johansen, A Konradsdottir, E Pundziute-Lyckå, A Samuelsson, U Skrivarhaug, T Svensson, J Body mass index standard deviation score and obesity in children with type 1 diabetes in the Nordic countries. HbA1c and other predictors of increasing BMISDS |
topic_facet |
BMISDS HbA Nordic countries insulin therapy modality obesity risk factors |
description |
BACKGROUND: Intensified insulin therapy may increase body weight and cause obesity. This study compared body mass index standard deviation score (BMISDS) and obesity rate in children with type 1 diabetes (T1D) in Denmark, Iceland, Norway and Sweden, and uncovered predictors for increasing BMISDS. METHODS: Data registered in the Nordic national childhood diabetes databases during the period 2008-2012 on children below 15 years with T1D for more than 3 months were compiled, including information on gender, age, diabetes duration, hemoglobin A1c (HbA1c ), insulin dose, severe hypoglycemia (SH), treatment modality, height and weight. The Swedish reference chart for BMI was used for calculating BMISDS. RESULTS: Totally, 11 025 children (48% females) (30 994 registrations) were included. Medians by the last recorded examination were: age, 13.5 years; diabetes duration, 4.3 years; HbA1c , 7.9% (63 mmol/mol); insulin dose, 0.8 IU/kg/d and BMISDS, 0.70. Obesity rate was 18.5%. Adjusted mean BMISDS (BMISDS adj) was inversely related to HbA1c and directly to diabetes duration. Higher BMISDS adj was found in those with an insulin dose above 0.6 IU/kg/d, and in girls above 10 years. Pump users had higher BMISDS adj than pen users, and patients with registered SH had higher BMISDS adj than patients without SH (both P < .001). CONCLUSION: Obesity rate in children with T1D in the Nordic countries is high, however, with country differences. Low HbA1c , long diabetes duration, higher insulin dose, pump treatment and experiencing a SH predicted higher BMISDS. Diabetes caregivers should balance the risk of obesity and the benefit of a very low HbA1c. |
format |
Article in Journal/Newspaper |
author |
Birkebaek, N H Kahlert, J Bjarnason, R Drivvoll, A K Johansen, A Konradsdottir, E Pundziute-Lyckå, A Samuelsson, U Skrivarhaug, T Svensson, J |
author_facet |
Birkebaek, N H Kahlert, J Bjarnason, R Drivvoll, A K Johansen, A Konradsdottir, E Pundziute-Lyckå, A Samuelsson, U Skrivarhaug, T Svensson, J |
author_sort |
Birkebaek, N H |
title |
Body mass index standard deviation score and obesity in children with type 1 diabetes in the Nordic countries. HbA1c and other predictors of increasing BMISDS |
title_short |
Body mass index standard deviation score and obesity in children with type 1 diabetes in the Nordic countries. HbA1c and other predictors of increasing BMISDS |
title_full |
Body mass index standard deviation score and obesity in children with type 1 diabetes in the Nordic countries. HbA1c and other predictors of increasing BMISDS |
title_fullStr |
Body mass index standard deviation score and obesity in children with type 1 diabetes in the Nordic countries. HbA1c and other predictors of increasing BMISDS |
title_full_unstemmed |
Body mass index standard deviation score and obesity in children with type 1 diabetes in the Nordic countries. HbA1c and other predictors of increasing BMISDS |
title_sort |
body mass index standard deviation score and obesity in children with type 1 diabetes in the nordic countries. hba1c and other predictors of increasing bmisds |
publishDate |
2018 |
url |
https://pure.au.dk/portal/en/publications/8feaa969-c2ef-4677-8cee-55dc0db619cc https://doi.org/10.1111/pedi.12693 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Birkebaek , N H , Kahlert , J , Bjarnason , R , Drivvoll , A K , Johansen , A , Konradsdottir , E , Pundziute-Lyckå , A , Samuelsson , U , Skrivarhaug , T , Svensson , J & Nordic Childhood Diabetes Registry Study Group, NordicDiabKids 2018 , ' Body mass index standard deviation score and obesity in children with type 1 diabetes in the Nordic countries. HbA1c and other predictors of increasing BMISDS ' , Pediatric Diabetes , vol. 19 , no. 7 , pp. 1198-1205 . https://doi.org/10.1111/pedi.12693 |
op_relation |
https://pure.au.dk/portal/en/publications/8feaa969-c2ef-4677-8cee-55dc0db619cc |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1111/pedi.12693 |
container_title |
Pediatric Diabetes |
container_volume |
19 |
container_issue |
7 |
container_start_page |
1198 |
op_container_end_page |
1205 |
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1797585666330066944 |