Hydroxylated polychlorinated biphenyls decrease circulating steroids in female polar bears (Ursus maritimus)
As a top predator in the Arctic food chain, polar bears (Ursus maritimus) are exposed to high levels of persistent organic pollutants (POPs). Because several of these compounds have been reported to alter endocrine pathways, such as the steroidogenesis, potential disruption of the sex steroid synthe...
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ftuniaarhuspubl:oai:pure.atira.dk:publications/76a7665f-5690-411b-9bf8-d945a03b2c93 2023-05-15T15:12:52+02:00 Hydroxylated polychlorinated biphenyls decrease circulating steroids in female polar bears (Ursus maritimus) Gustavson, Lisa Ciesielski, Tomasz M. Bytingsvik, Jenny Styrishave, Bjarne Hansen, Martin Lie, Elisabeth Aars, Jon Jenssen, Bjørn M 2015-04-01 https://pure.au.dk/portal/da/publications/hydroxylated-polychlorinated-biphenyls-decrease-circulating-steroids-in-female-polar-bears-ursus-maritimus(76a7665f-5690-411b-9bf8-d945a03b2c93).html http://www.sciencedirect.com/science/article/pii/S0013935115000390 eng eng info:eu-repo/semantics/restrictedAccess Gustavson , L , Ciesielski , T M , Bytingsvik , J , Styrishave , B , Hansen , M , Lie , E , Aars , J & Jenssen , B M 2015 , ' Hydroxylated polychlorinated biphenyls decrease circulating steroids in female polar bears (Ursus maritimus) ' , Environmental Research , vol. 138 , pp. 191-201 . < http://www.sciencedirect.com/science/article/pii/S0013935115000390 > article 2015 ftuniaarhuspubl 2020-10-21T22:46:19Z As a top predator in the Arctic food chain, polar bears (Ursus maritimus) are exposed to high levels of persistent organic pollutants (POPs). Because several of these compounds have been reported to alter endocrine pathways, such as the steroidogenesis, potential disruption of the sex steroid synthesis by POPs may cause implications for reproduction by interfering with ovulation, implantation and fertility. Blood samples were collected from 15 female polar bears in Svalbard (Norway) in April 2008. The concentrations of nine circulating steroid hormones; dehydroepiandrosterone (DHEA), androstenedione (AN), testosterone (TS), dihydrotestosterone (DHT), estrone (E1), 17α-estradiol (αE2), 17β-estradiol (βE2), pregnenolone (PRE) and progesterone (PRO) were determined. The aim of the study was to investigate associations among circulating levels of specific POP compounds and POP-metabolites (hydroxylated PCBs [OH-PCBs] and hydroxylated PBDEs [OH-PBDEs]), steroid hormones, biological and capture variables in female polar bears. Inverse correlations were found between circulating levels of PRE and AN, and circulating levels of OH-PCBs. There were no significant relationships between the steroid concentrations and other analyzed POPs or the variables capture date and capture location (latitude and longitude), lipid content, condition and body mass. Although statistical associations do not necessarily represent direct cause-effect relationships, the present study indicate that OH-PCBs may affect the circulating levels of AN and PRE in female polar bears and that OH-PCBs thus may interfere with the steroid homeostasis. Increase in PRO and a decrease in AN concentrations suggest that the enzyme CYP17 may be a potential target for OH-PCBs. In combination with natural stressors, ongoing climate change and contaminant exposure, it is possible that OH-PCBs may disturb the reproductive potential of polar bears. Article in Journal/Newspaper Arctic Climate change Svalbard Ursus maritimus Aarhus University: Research Arctic Norway Svalbard |
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Open Polar |
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Aarhus University: Research |
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ftuniaarhuspubl |
language |
English |
description |
As a top predator in the Arctic food chain, polar bears (Ursus maritimus) are exposed to high levels of persistent organic pollutants (POPs). Because several of these compounds have been reported to alter endocrine pathways, such as the steroidogenesis, potential disruption of the sex steroid synthesis by POPs may cause implications for reproduction by interfering with ovulation, implantation and fertility. Blood samples were collected from 15 female polar bears in Svalbard (Norway) in April 2008. The concentrations of nine circulating steroid hormones; dehydroepiandrosterone (DHEA), androstenedione (AN), testosterone (TS), dihydrotestosterone (DHT), estrone (E1), 17α-estradiol (αE2), 17β-estradiol (βE2), pregnenolone (PRE) and progesterone (PRO) were determined. The aim of the study was to investigate associations among circulating levels of specific POP compounds and POP-metabolites (hydroxylated PCBs [OH-PCBs] and hydroxylated PBDEs [OH-PBDEs]), steroid hormones, biological and capture variables in female polar bears. Inverse correlations were found between circulating levels of PRE and AN, and circulating levels of OH-PCBs. There were no significant relationships between the steroid concentrations and other analyzed POPs or the variables capture date and capture location (latitude and longitude), lipid content, condition and body mass. Although statistical associations do not necessarily represent direct cause-effect relationships, the present study indicate that OH-PCBs may affect the circulating levels of AN and PRE in female polar bears and that OH-PCBs thus may interfere with the steroid homeostasis. Increase in PRO and a decrease in AN concentrations suggest that the enzyme CYP17 may be a potential target for OH-PCBs. In combination with natural stressors, ongoing climate change and contaminant exposure, it is possible that OH-PCBs may disturb the reproductive potential of polar bears. |
format |
Article in Journal/Newspaper |
author |
Gustavson, Lisa Ciesielski, Tomasz M. Bytingsvik, Jenny Styrishave, Bjarne Hansen, Martin Lie, Elisabeth Aars, Jon Jenssen, Bjørn M |
spellingShingle |
Gustavson, Lisa Ciesielski, Tomasz M. Bytingsvik, Jenny Styrishave, Bjarne Hansen, Martin Lie, Elisabeth Aars, Jon Jenssen, Bjørn M Hydroxylated polychlorinated biphenyls decrease circulating steroids in female polar bears (Ursus maritimus) |
author_facet |
Gustavson, Lisa Ciesielski, Tomasz M. Bytingsvik, Jenny Styrishave, Bjarne Hansen, Martin Lie, Elisabeth Aars, Jon Jenssen, Bjørn M |
author_sort |
Gustavson, Lisa |
title |
Hydroxylated polychlorinated biphenyls decrease circulating steroids in female polar bears (Ursus maritimus) |
title_short |
Hydroxylated polychlorinated biphenyls decrease circulating steroids in female polar bears (Ursus maritimus) |
title_full |
Hydroxylated polychlorinated biphenyls decrease circulating steroids in female polar bears (Ursus maritimus) |
title_fullStr |
Hydroxylated polychlorinated biphenyls decrease circulating steroids in female polar bears (Ursus maritimus) |
title_full_unstemmed |
Hydroxylated polychlorinated biphenyls decrease circulating steroids in female polar bears (Ursus maritimus) |
title_sort |
hydroxylated polychlorinated biphenyls decrease circulating steroids in female polar bears (ursus maritimus) |
publishDate |
2015 |
url |
https://pure.au.dk/portal/da/publications/hydroxylated-polychlorinated-biphenyls-decrease-circulating-steroids-in-female-polar-bears-ursus-maritimus(76a7665f-5690-411b-9bf8-d945a03b2c93).html http://www.sciencedirect.com/science/article/pii/S0013935115000390 |
geographic |
Arctic Norway Svalbard |
geographic_facet |
Arctic Norway Svalbard |
genre |
Arctic Climate change Svalbard Ursus maritimus |
genre_facet |
Arctic Climate change Svalbard Ursus maritimus |
op_source |
Gustavson , L , Ciesielski , T M , Bytingsvik , J , Styrishave , B , Hansen , M , Lie , E , Aars , J & Jenssen , B M 2015 , ' Hydroxylated polychlorinated biphenyls decrease circulating steroids in female polar bears (Ursus maritimus) ' , Environmental Research , vol. 138 , pp. 191-201 . < http://www.sciencedirect.com/science/article/pii/S0013935115000390 > |
op_rights |
info:eu-repo/semantics/restrictedAccess |
_version_ |
1766343505197662208 |