Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east greenland polar bears (Ursus maritimus)
The present study investigated the comparative accumulation of perfluoroalkyl acids (PFAAs) in eight brain regions of polar bears (Ursus maritimus, n = 19) collected in 2006 from Scoresby Sound, East Greenland. The PFAAs studied were perfluoroalkyl carboxylates (PFCAs, C(6) -C(15) chain lengths) and...
Published in: | Environmental Toxicology and Chemistry |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/75f75e70-e4f5-48f0-a4ce-ff24cf8cb540 2023-05-15T16:03:39+02:00 Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east greenland polar bears (Ursus maritimus) Greaves, Alana K Letcher, Robert J Sonne, Christian Dietz, Rune 2013-03 https://pure.au.dk/portal/da/publications/brain-region-distribution-and-patterns-of-bioaccumulative-perfluoroalkyl-carboxylates-and-sulfonates-in-east-greenland-polar-bears-ursus-maritimus(75f75e70-e4f5-48f0-a4ce-ff24cf8cb540).html https://doi.org/10.1002/etc.2107 eng eng info:eu-repo/semantics/restrictedAccess Greaves , A K , Letcher , R J , Sonne , C & Dietz , R 2013 , ' Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east greenland polar bears (Ursus maritimus) ' , Environmental Toxicology and Chemistry , vol. 32 , no. 3 , pp. 713-722 . https://doi.org/10.1002/etc.2107 article 2013 ftuniaarhuspubl https://doi.org/10.1002/etc.2107 2020-07-18T21:25:38Z The present study investigated the comparative accumulation of perfluoroalkyl acids (PFAAs) in eight brain regions of polar bears (Ursus maritimus, n = 19) collected in 2006 from Scoresby Sound, East Greenland. The PFAAs studied were perfluoroalkyl carboxylates (PFCAs, C(6) -C(15) chain lengths) and sulfonates (C(4) , C(6) , C(8) , and C(10) chain lengths) as well as selected precursors including perfluorooctane sulfonamide. On a wet-weight basis, blood-brain barrier transport of PFAAs occurred for all brain regions, although inner regions of the brain closer to incoming blood flow (pons/medulla, thalamus, and hypothalamus) contained consistently higher PFAA concentrations compared to outer brain regions (cerebellum, striatum, and frontal, occipital, and temporal cortices). For pons/medulla, thalamus, and hypothalamus, the most concentrated PFAAs were perfluorooctane sulfonate (PFOS), ranging from 47 to 58 ng/g wet weight, and perfluorotridecanoic acid, ranging from 43 to 49 ng/g wet weight. However, PFOS and the longer-chain PFCAs (C(10) -C(15) ) were significantly (p 0.05) different among brain regions. The burden of the sum of PFCAs, perfluoroalkyl sulfonates, and perfluorooctane sulfonamide in the brain (average mass, 392 g) was estimated to be 46 µg. The present study demonstrates that both PFCAs and perfluoroalkyl sulfonates cross the blood-brain barrier in polar bears and that wet-weight concentrations are brain region-specific. Article in Journal/Newspaper East Greenland Greenland Scoresby Sound Ursus maritimus Aarhus University: Research Greenland Scoresby ENVELOPE(162.750,162.750,-66.567,-66.567) Environmental Toxicology and Chemistry 32 3 713 722 |
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Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
description |
The present study investigated the comparative accumulation of perfluoroalkyl acids (PFAAs) in eight brain regions of polar bears (Ursus maritimus, n = 19) collected in 2006 from Scoresby Sound, East Greenland. The PFAAs studied were perfluoroalkyl carboxylates (PFCAs, C(6) -C(15) chain lengths) and sulfonates (C(4) , C(6) , C(8) , and C(10) chain lengths) as well as selected precursors including perfluorooctane sulfonamide. On a wet-weight basis, blood-brain barrier transport of PFAAs occurred for all brain regions, although inner regions of the brain closer to incoming blood flow (pons/medulla, thalamus, and hypothalamus) contained consistently higher PFAA concentrations compared to outer brain regions (cerebellum, striatum, and frontal, occipital, and temporal cortices). For pons/medulla, thalamus, and hypothalamus, the most concentrated PFAAs were perfluorooctane sulfonate (PFOS), ranging from 47 to 58 ng/g wet weight, and perfluorotridecanoic acid, ranging from 43 to 49 ng/g wet weight. However, PFOS and the longer-chain PFCAs (C(10) -C(15) ) were significantly (p 0.05) different among brain regions. The burden of the sum of PFCAs, perfluoroalkyl sulfonates, and perfluorooctane sulfonamide in the brain (average mass, 392 g) was estimated to be 46 µg. The present study demonstrates that both PFCAs and perfluoroalkyl sulfonates cross the blood-brain barrier in polar bears and that wet-weight concentrations are brain region-specific. |
format |
Article in Journal/Newspaper |
author |
Greaves, Alana K Letcher, Robert J Sonne, Christian Dietz, Rune |
spellingShingle |
Greaves, Alana K Letcher, Robert J Sonne, Christian Dietz, Rune Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east greenland polar bears (Ursus maritimus) |
author_facet |
Greaves, Alana K Letcher, Robert J Sonne, Christian Dietz, Rune |
author_sort |
Greaves, Alana K |
title |
Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east greenland polar bears (Ursus maritimus) |
title_short |
Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east greenland polar bears (Ursus maritimus) |
title_full |
Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east greenland polar bears (Ursus maritimus) |
title_fullStr |
Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east greenland polar bears (Ursus maritimus) |
title_full_unstemmed |
Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east greenland polar bears (Ursus maritimus) |
title_sort |
brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east greenland polar bears (ursus maritimus) |
publishDate |
2013 |
url |
https://pure.au.dk/portal/da/publications/brain-region-distribution-and-patterns-of-bioaccumulative-perfluoroalkyl-carboxylates-and-sulfonates-in-east-greenland-polar-bears-ursus-maritimus(75f75e70-e4f5-48f0-a4ce-ff24cf8cb540).html https://doi.org/10.1002/etc.2107 |
long_lat |
ENVELOPE(162.750,162.750,-66.567,-66.567) |
geographic |
Greenland Scoresby |
geographic_facet |
Greenland Scoresby |
genre |
East Greenland Greenland Scoresby Sound Ursus maritimus |
genre_facet |
East Greenland Greenland Scoresby Sound Ursus maritimus |
op_source |
Greaves , A K , Letcher , R J , Sonne , C & Dietz , R 2013 , ' Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east greenland polar bears (Ursus maritimus) ' , Environmental Toxicology and Chemistry , vol. 32 , no. 3 , pp. 713-722 . https://doi.org/10.1002/etc.2107 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1002/etc.2107 |
container_title |
Environmental Toxicology and Chemistry |
container_volume |
32 |
container_issue |
3 |
container_start_page |
713 |
op_container_end_page |
722 |
_version_ |
1766399350297067520 |