Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3-5 years of age:a Greenlandic cohort study
High levels of persistent organic pollutants (POPs) and heavy metals are found in Arctic populations. POP and heavy metals are linked to impaired cognitive development. This study examined associations between prenatal POP and metals exposure and problematic child behavior using the Strength and Dif...
Published in: | Scientific Reports |
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2021
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Online Access: | https://pure.au.dk/portal/da/publications/prenatal-exposure-to-persistent-organic-pollutants-and-metals-and-problematic-child-behavior-at-35-years-of-age(751ebf99-d1d4-4c48-962f-29ceace6c103).html https://doi.org/10.1038/s41598-021-01580-0 |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/751ebf99-d1d4-4c48-962f-29ceace6c103 2023-05-15T15:10:00+02:00 Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3-5 years of age:a Greenlandic cohort study Kornvig, Simon Wielsøe, Maria Long, Manhai Bonefeld-Jørgensen, Eva Cecilie 2021-11 https://pure.au.dk/portal/da/publications/prenatal-exposure-to-persistent-organic-pollutants-and-metals-and-problematic-child-behavior-at-35-years-of-age(751ebf99-d1d4-4c48-962f-29ceace6c103).html https://doi.org/10.1038/s41598-021-01580-0 eng eng info:eu-repo/semantics/openAccess Kornvig , S , Wielsøe , M , Long , M & Bonefeld-Jørgensen , E C 2021 , ' Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3-5 years of age : a Greenlandic cohort study ' , Scientific Reports , vol. 11 , 22182 . https://doi.org/10.1038/s41598-021-01580-0 ATTENTION DEFICIT/HYPERACTIVITY DISORDER CORD BLOOD DIFFICULTIES QUESTIONNAIRE ENVIRONMENTAL CONTAMINANTS FALSE DISCOVERY RATE ORGANOCHLORINE PESTICIDES PERFLUORINATED COMPOUNDS PERFLUOROALKYL SUBSTANCES PERFLUOROOCTANE SULFONATE POLYCHLORINATED-BIPHENYLS article 2021 ftuniaarhuspubl https://doi.org/10.1038/s41598-021-01580-0 2022-02-16T23:49:52Z High levels of persistent organic pollutants (POPs) and heavy metals are found in Arctic populations. POP and heavy metals are linked to impaired cognitive development. This study examined associations between prenatal POP and metals exposure and problematic child behavior using the Strength and Difficulties Questionnaire (SDQ). POPs and metals were measured in 102 pregnant Greenlandic women. During follow-up at 3-5 years, parents answered an assisted questionnaire including children's SDQ scores. Associations were analyzed using linear and logistic regression analyses and adjusted for maternal plasma cotinine, educational level and age at delivery. In the adjusted analyses, the medium tertile of hexachlorobenzene (β = 3.06, p = 0.010), β-hexachlorocyclohexane (β = 3.58, p = 0.004) and trans-nonachlor (β = 2.06, p = 0.082) were positively associated with SDQ scores. The continuous cis-nonachlor (OR = 1.09, p = 0.079), dichloro-diphenyl-dichloroethylene (OR = 1.01, p = 0.077), trans-nonachlor (OR = 1.01, p = 0.091), and sum Organochlorine-Pesticides (OR = 1.00, p = 0.094) were positively associated with abnormal SDQ score and the continuous mirex (OR = 1.28, p = 0.096), oxychlordane (OR = 1.04, p = 0.066), and trans-nonachlor (OR = 1.02, p = 0.071) with abnormal hyperactivity score. We found no consistent evidence of associations between polychlorinated biphenyls, perfluoroalkylated substances and heavy metals and problematic behavior. Prenatal organochlorine pesticide exposure associated significantly with problematic behavior in 3-5 year old children. Article in Journal/Newspaper Arctic greenlandic Aarhus University: Research Arctic Scientific Reports 11 1 |
institution |
Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
ATTENTION DEFICIT/HYPERACTIVITY DISORDER CORD BLOOD DIFFICULTIES QUESTIONNAIRE ENVIRONMENTAL CONTAMINANTS FALSE DISCOVERY RATE ORGANOCHLORINE PESTICIDES PERFLUORINATED COMPOUNDS PERFLUOROALKYL SUBSTANCES PERFLUOROOCTANE SULFONATE POLYCHLORINATED-BIPHENYLS |
spellingShingle |
ATTENTION DEFICIT/HYPERACTIVITY DISORDER CORD BLOOD DIFFICULTIES QUESTIONNAIRE ENVIRONMENTAL CONTAMINANTS FALSE DISCOVERY RATE ORGANOCHLORINE PESTICIDES PERFLUORINATED COMPOUNDS PERFLUOROALKYL SUBSTANCES PERFLUOROOCTANE SULFONATE POLYCHLORINATED-BIPHENYLS Kornvig, Simon Wielsøe, Maria Long, Manhai Bonefeld-Jørgensen, Eva Cecilie Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3-5 years of age:a Greenlandic cohort study |
topic_facet |
ATTENTION DEFICIT/HYPERACTIVITY DISORDER CORD BLOOD DIFFICULTIES QUESTIONNAIRE ENVIRONMENTAL CONTAMINANTS FALSE DISCOVERY RATE ORGANOCHLORINE PESTICIDES PERFLUORINATED COMPOUNDS PERFLUOROALKYL SUBSTANCES PERFLUOROOCTANE SULFONATE POLYCHLORINATED-BIPHENYLS |
description |
High levels of persistent organic pollutants (POPs) and heavy metals are found in Arctic populations. POP and heavy metals are linked to impaired cognitive development. This study examined associations between prenatal POP and metals exposure and problematic child behavior using the Strength and Difficulties Questionnaire (SDQ). POPs and metals were measured in 102 pregnant Greenlandic women. During follow-up at 3-5 years, parents answered an assisted questionnaire including children's SDQ scores. Associations were analyzed using linear and logistic regression analyses and adjusted for maternal plasma cotinine, educational level and age at delivery. In the adjusted analyses, the medium tertile of hexachlorobenzene (β = 3.06, p = 0.010), β-hexachlorocyclohexane (β = 3.58, p = 0.004) and trans-nonachlor (β = 2.06, p = 0.082) were positively associated with SDQ scores. The continuous cis-nonachlor (OR = 1.09, p = 0.079), dichloro-diphenyl-dichloroethylene (OR = 1.01, p = 0.077), trans-nonachlor (OR = 1.01, p = 0.091), and sum Organochlorine-Pesticides (OR = 1.00, p = 0.094) were positively associated with abnormal SDQ score and the continuous mirex (OR = 1.28, p = 0.096), oxychlordane (OR = 1.04, p = 0.066), and trans-nonachlor (OR = 1.02, p = 0.071) with abnormal hyperactivity score. We found no consistent evidence of associations between polychlorinated biphenyls, perfluoroalkylated substances and heavy metals and problematic behavior. Prenatal organochlorine pesticide exposure associated significantly with problematic behavior in 3-5 year old children. |
format |
Article in Journal/Newspaper |
author |
Kornvig, Simon Wielsøe, Maria Long, Manhai Bonefeld-Jørgensen, Eva Cecilie |
author_facet |
Kornvig, Simon Wielsøe, Maria Long, Manhai Bonefeld-Jørgensen, Eva Cecilie |
author_sort |
Kornvig, Simon |
title |
Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3-5 years of age:a Greenlandic cohort study |
title_short |
Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3-5 years of age:a Greenlandic cohort study |
title_full |
Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3-5 years of age:a Greenlandic cohort study |
title_fullStr |
Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3-5 years of age:a Greenlandic cohort study |
title_full_unstemmed |
Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3-5 years of age:a Greenlandic cohort study |
title_sort |
prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3-5 years of age:a greenlandic cohort study |
publishDate |
2021 |
url |
https://pure.au.dk/portal/da/publications/prenatal-exposure-to-persistent-organic-pollutants-and-metals-and-problematic-child-behavior-at-35-years-of-age(751ebf99-d1d4-4c48-962f-29ceace6c103).html https://doi.org/10.1038/s41598-021-01580-0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic greenlandic |
genre_facet |
Arctic greenlandic |
op_source |
Kornvig , S , Wielsøe , M , Long , M & Bonefeld-Jørgensen , E C 2021 , ' Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3-5 years of age : a Greenlandic cohort study ' , Scientific Reports , vol. 11 , 22182 . https://doi.org/10.1038/s41598-021-01580-0 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/s41598-021-01580-0 |
container_title |
Scientific Reports |
container_volume |
11 |
container_issue |
1 |
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1766341081224445952 |