Estrogen-like activities in blood cleared for endogenous steroid hormones across European and Inuit populations

• Main Authors: Hjelmborg, Philip Sebastian, Andersen, Birgitte Sloth, Sinnathamby, Thayline, Goralczyk, Katarzyna, Pedersen, Henning S., Shvets, Mayna, Rignell-Hydbom, Anna, Bonefeld-Jørgensen, Eva Cecilie
• Format: Conference Object
• Language: English
• Published: 2005
• Subjects: inuit
• Online Access: https://pure.au.dk/portal/da/publications/estrogenlike-activities-in-blood-cleared-for-endogenous-steroid-hormones-across-european-and-inuit-populations(71bc1d70-c7ea-11db-bee9-02004c4f4f50).html; https://pure.au.dk/ws/files/1192366/Poster_som_pdf

Human exposure to environmental contaminants is ubiquitous and can affect individuals living close to as well as remote from the sources of contaminants. All individuals carry a burden of the lipophilic persistent organic pollutants (POPs) and heavy metals in their body. POPs includes polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs) and certain pesticide residues e.g. dichloro-diphenyl-trichloroethane/dichloro-diphenyl-dichloroethylene (DDT/DDE), toxaphenes, β-hexachlorocyclohexane (β-HCH), chlordanes, hexachlorobenzene, and Mirex. Exposure to POPs elicits a number of species- and tissue-specific toxic responses including effects on the reproductive-, immune- and thyroid system. Study on wildlife populations have documented adverse effects, including reproductive end developmental effects that correlate with exposure to one or more of these endocrine modulating chemicals. Especially the exposure during foetal and early life is critical. Although, no clear cut evidence for adverse endocrine-related human health effects has been obtained, the reasonable suspicion based on wildlife, animal and laboratory studies strengthened the need for further research to address the uncertainty and concern. There are a number of factors that complicate the toxicological assessment. Firstly, it is important to remember that no individual is exposed to a single contaminant but to a complex mixture of contaminants, which is life-long beginning during critical developmental windows.