Antidiabetic medication use during pregnancy:An international utilization study
Objective Diabetes in pregnancy and consequently the need for treatment with antidiabetic medication (ADM) has become increasingly prevalent. The prevalence and patterns of use of ADM in pregnancy from 2006 onward in seven different countries was assessed. Research design and methods Data sources in...
Published in: | BMJ Open Diabetes Research & Care |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/4fb4c03f-a524-4c7f-81b6-5f4351d1ca74 2024-09-15T18:14:22+00:00 Antidiabetic medication use during pregnancy:An international utilization study Cesta, Carolyn E. Cohen, Jacqueline M. Pazzagli, Laura Bateman, Brian T. Bröms, Gabriella Einarsdóttir, Kristjana Furu, Kari Havard, Alys Heino, Anna Hernandez-DIaz, Sonia Huybrechts, Krista F. Karlstad, Øystein Kieler, Helle Li, Jiong Leinonen, Maarit K. Gulseth, Hanne L. Tran, Duong Yu, Yongfu Zoega, Helga Odsbu, Ingvild 2019 https://pure.au.dk/portal/en/publications/4fb4c03f-a524-4c7f-81b6-5f4351d1ca74 https://doi.org/10.1136/bmjdrc-2019-000759 http://www.scopus.com/inward/record.url?scp=85074654996&partnerID=8YFLogxK eng eng https://pure.au.dk/portal/en/publications/4fb4c03f-a524-4c7f-81b6-5f4351d1ca74 info:eu-repo/semantics/openAccess Cesta , C E , Cohen , J M , Pazzagli , L , Bateman , B T , Bröms , G , Einarsdóttir , K , Furu , K , Havard , A , Heino , A , Hernandez-DIaz , S , Huybrechts , K F , Karlstad , Ø , Kieler , H , Li , J , Leinonen , M K , Gulseth , H L , Tran , D , Yu , Y , Zoega , H & Odsbu , I 2019 , ' Antidiabetic medication use during pregnancy : An international utilization study ' , BMJ Open Diabetes Research & Care , vol. 7 , no. 1 , 000903 . https://doi.org/10.1136/bmjdrc-2019-000759 drug utilization gestational diabetes mellitus insulin oral antidiabetics pharmacoepidemiology population-based studies pregestational diabetes pregnancy article 2019 ftuniaarhuspubl https://doi.org/10.1136/bmjdrc-2019-000759 2024-06-25T14:16:19Z Objective Diabetes in pregnancy and consequently the need for treatment with antidiabetic medication (ADM) has become increasingly prevalent. The prevalence and patterns of use of ADM in pregnancy from 2006 onward in seven different countries was assessed. Research design and methods Data sources included individually linked data from the nationwide health registers in Denmark (2006-2016), Finland (2006-2016), Iceland (2006-2012), Norway (2006-2015), Sweden (2006-2015), state-wide administrative and claims data for New South Wales, Australia (2006-2012) and two US insurance databases: Medicaid Analytic eXtract (MAX; 2006-2012, public) and IBM MarketScan (2012-2015, private). The prevalence of ADM use was calculated as the proportion of pregnancies with at least one filled prescription of an ADM in the 90 days before pregnancy or within the three trimesters of pregnancy. Results Prevalence of any ADM use in 5 279 231 pregnancies was 3% (n=147 999) and varied from under 2% (Denmark, Norway, and Sweden) to above 5% (Australia and US). Insulin was the most used ADM, and metformin was the most used oral hypoglycemic agent with increasing use over time in all countries. In 11.4%-62.5% of pregnancies with prepregnancy use, ADM (primarily metformin) was discontinued. When ADM treatment was initiated in late pregnancy for treatment of gestational diabetes mellitus, insulin was most often dispensed, except in the US, where glibenclamide was most often used. Conclusions Prevalence and patterns of use of ADM classes varied between countries and over time. While insulin remained the most common ADM used in pregnancy, metformin use increased significantly over the study period. Article in Journal/Newspaper Iceland Aarhus University: Research BMJ Open Diabetes Research & Care 7 1 e000759 |
institution |
Open Polar |
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Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
drug utilization gestational diabetes mellitus insulin oral antidiabetics pharmacoepidemiology population-based studies pregestational diabetes pregnancy |
spellingShingle |
drug utilization gestational diabetes mellitus insulin oral antidiabetics pharmacoepidemiology population-based studies pregestational diabetes pregnancy Cesta, Carolyn E. Cohen, Jacqueline M. Pazzagli, Laura Bateman, Brian T. Bröms, Gabriella Einarsdóttir, Kristjana Furu, Kari Havard, Alys Heino, Anna Hernandez-DIaz, Sonia Huybrechts, Krista F. Karlstad, Øystein Kieler, Helle Li, Jiong Leinonen, Maarit K. Gulseth, Hanne L. Tran, Duong Yu, Yongfu Zoega, Helga Odsbu, Ingvild Antidiabetic medication use during pregnancy:An international utilization study |
topic_facet |
drug utilization gestational diabetes mellitus insulin oral antidiabetics pharmacoepidemiology population-based studies pregestational diabetes pregnancy |
description |
Objective Diabetes in pregnancy and consequently the need for treatment with antidiabetic medication (ADM) has become increasingly prevalent. The prevalence and patterns of use of ADM in pregnancy from 2006 onward in seven different countries was assessed. Research design and methods Data sources included individually linked data from the nationwide health registers in Denmark (2006-2016), Finland (2006-2016), Iceland (2006-2012), Norway (2006-2015), Sweden (2006-2015), state-wide administrative and claims data for New South Wales, Australia (2006-2012) and two US insurance databases: Medicaid Analytic eXtract (MAX; 2006-2012, public) and IBM MarketScan (2012-2015, private). The prevalence of ADM use was calculated as the proportion of pregnancies with at least one filled prescription of an ADM in the 90 days before pregnancy or within the three trimesters of pregnancy. Results Prevalence of any ADM use in 5 279 231 pregnancies was 3% (n=147 999) and varied from under 2% (Denmark, Norway, and Sweden) to above 5% (Australia and US). Insulin was the most used ADM, and metformin was the most used oral hypoglycemic agent with increasing use over time in all countries. In 11.4%-62.5% of pregnancies with prepregnancy use, ADM (primarily metformin) was discontinued. When ADM treatment was initiated in late pregnancy for treatment of gestational diabetes mellitus, insulin was most often dispensed, except in the US, where glibenclamide was most often used. Conclusions Prevalence and patterns of use of ADM classes varied between countries and over time. While insulin remained the most common ADM used in pregnancy, metformin use increased significantly over the study period. |
format |
Article in Journal/Newspaper |
author |
Cesta, Carolyn E. Cohen, Jacqueline M. Pazzagli, Laura Bateman, Brian T. Bröms, Gabriella Einarsdóttir, Kristjana Furu, Kari Havard, Alys Heino, Anna Hernandez-DIaz, Sonia Huybrechts, Krista F. Karlstad, Øystein Kieler, Helle Li, Jiong Leinonen, Maarit K. Gulseth, Hanne L. Tran, Duong Yu, Yongfu Zoega, Helga Odsbu, Ingvild |
author_facet |
Cesta, Carolyn E. Cohen, Jacqueline M. Pazzagli, Laura Bateman, Brian T. Bröms, Gabriella Einarsdóttir, Kristjana Furu, Kari Havard, Alys Heino, Anna Hernandez-DIaz, Sonia Huybrechts, Krista F. Karlstad, Øystein Kieler, Helle Li, Jiong Leinonen, Maarit K. Gulseth, Hanne L. Tran, Duong Yu, Yongfu Zoega, Helga Odsbu, Ingvild |
author_sort |
Cesta, Carolyn E. |
title |
Antidiabetic medication use during pregnancy:An international utilization study |
title_short |
Antidiabetic medication use during pregnancy:An international utilization study |
title_full |
Antidiabetic medication use during pregnancy:An international utilization study |
title_fullStr |
Antidiabetic medication use during pregnancy:An international utilization study |
title_full_unstemmed |
Antidiabetic medication use during pregnancy:An international utilization study |
title_sort |
antidiabetic medication use during pregnancy:an international utilization study |
publishDate |
2019 |
url |
https://pure.au.dk/portal/en/publications/4fb4c03f-a524-4c7f-81b6-5f4351d1ca74 https://doi.org/10.1136/bmjdrc-2019-000759 http://www.scopus.com/inward/record.url?scp=85074654996&partnerID=8YFLogxK |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Cesta , C E , Cohen , J M , Pazzagli , L , Bateman , B T , Bröms , G , Einarsdóttir , K , Furu , K , Havard , A , Heino , A , Hernandez-DIaz , S , Huybrechts , K F , Karlstad , Ø , Kieler , H , Li , J , Leinonen , M K , Gulseth , H L , Tran , D , Yu , Y , Zoega , H & Odsbu , I 2019 , ' Antidiabetic medication use during pregnancy : An international utilization study ' , BMJ Open Diabetes Research & Care , vol. 7 , no. 1 , 000903 . https://doi.org/10.1136/bmjdrc-2019-000759 |
op_relation |
https://pure.au.dk/portal/en/publications/4fb4c03f-a524-4c7f-81b6-5f4351d1ca74 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1136/bmjdrc-2019-000759 |
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BMJ Open Diabetes Research & Care |
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7 |
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1 |
container_start_page |
e000759 |
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