Persistent organic pollutants in Greenlandic pregnant women and indices of foetal growth:The ACCEPT study
The Greenlandic population has some of the highest levels of environmental persistent organic pollutants (POPs) globally. Studies have previously found POPs to be linked with disturbance of child development, immune function and reproductive abilities. We investigated the associations between serum...
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ftuniaarhuspubl:oai:pure.atira.dk:publications/40ad56fc-b7d6-47d7-9400-c6c5bf807334 2023-05-15T16:28:08+02:00 Persistent organic pollutants in Greenlandic pregnant women and indices of foetal growth:The ACCEPT study Hjermitslev, Marie Harthøj Long, Manhai Wielsøe, Maria Bonefeld-Jørgensen, Eva C 2020 https://pure.au.dk/portal/da/publications/persistent-organic-pollutants-in-greenlandic-pregnant-women-and-indices-of-foetal-growth(40ad56fc-b7d6-47d7-9400-c6c5bf807334).html https://doi.org/10.1016/j.scitotenv.2019.134118 eng eng info:eu-repo/semantics/closedAccess Hjermitslev , M H , Long , M , Wielsøe , M & Bonefeld-Jørgensen , E C 2020 , ' Persistent organic pollutants in Greenlandic pregnant women and indices of foetal growth : The ACCEPT study ' , The Science of the Total Environment , vol. 698 , 134118 . https://doi.org/10.1016/j.scitotenv.2019.134118 lipophilic persistent organic pollutants perfluoroalkylated substances pregnant Greenland article 2020 ftuniaarhuspubl https://doi.org/10.1016/j.scitotenv.2019.134118 2023-01-11T23:55:32Z The Greenlandic population has some of the highest levels of environmental persistent organic pollutants (POPs) globally. Studies have previously found POPs to be linked with disturbance of child development, immune function and reproductive abilities. We investigated the associations between serum POP levels of pregnant women in Greenland and their infant's birth weight, length, head circumference and gestational age (GA) at birth. Pregnant Greenlandic women (n = 504) were enrolled during pregnancy and serum levels of the lipophilic POPs (Organochlorine pesticides, Polychlorinated biphenyls and Polybrominated diphenyl ethers) and the amphiphilic POPs, Perfluoroalkylated substances (PFASs), were measured. We analysed the associations between maternal serum levels of POPs and birth weight, length, head circumference and GA using linear regression analysis. We found significant inverse associations between Perfluorooctanoic Acid (PFOA) and birth weight (adjusted β = -119 g, 95% CI: -201; -36), birth length (adjusted β = -0.37 cm, 95% CI: -0.76; 0.02, borderline significant) and head circumference (adjusted β = -0.35 cm, 95% CI: -0.59; -0.10) and a positive association with GA (adjusted β = 0.45 week, 95% CI: 0.17; 0.74). For the lipophilic POPs, we found an overall trend of inverse associations to foetal growth indices. In conclusion, we found that the amphiphilic PFOA had a significant inversely association with foetal growth indices, whereas GA was positively associated. The data indicate that POPs have a negative effect on foetal growth. Article in Journal/Newspaper Greenland greenlandic Aarhus University: Research Greenland Science of The Total Environment 698 134118 |
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Open Polar |
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Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
lipophilic persistent organic pollutants perfluoroalkylated substances pregnant Greenland |
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lipophilic persistent organic pollutants perfluoroalkylated substances pregnant Greenland Hjermitslev, Marie Harthøj Long, Manhai Wielsøe, Maria Bonefeld-Jørgensen, Eva C Persistent organic pollutants in Greenlandic pregnant women and indices of foetal growth:The ACCEPT study |
topic_facet |
lipophilic persistent organic pollutants perfluoroalkylated substances pregnant Greenland |
description |
The Greenlandic population has some of the highest levels of environmental persistent organic pollutants (POPs) globally. Studies have previously found POPs to be linked with disturbance of child development, immune function and reproductive abilities. We investigated the associations between serum POP levels of pregnant women in Greenland and their infant's birth weight, length, head circumference and gestational age (GA) at birth. Pregnant Greenlandic women (n = 504) were enrolled during pregnancy and serum levels of the lipophilic POPs (Organochlorine pesticides, Polychlorinated biphenyls and Polybrominated diphenyl ethers) and the amphiphilic POPs, Perfluoroalkylated substances (PFASs), were measured. We analysed the associations between maternal serum levels of POPs and birth weight, length, head circumference and GA using linear regression analysis. We found significant inverse associations between Perfluorooctanoic Acid (PFOA) and birth weight (adjusted β = -119 g, 95% CI: -201; -36), birth length (adjusted β = -0.37 cm, 95% CI: -0.76; 0.02, borderline significant) and head circumference (adjusted β = -0.35 cm, 95% CI: -0.59; -0.10) and a positive association with GA (adjusted β = 0.45 week, 95% CI: 0.17; 0.74). For the lipophilic POPs, we found an overall trend of inverse associations to foetal growth indices. In conclusion, we found that the amphiphilic PFOA had a significant inversely association with foetal growth indices, whereas GA was positively associated. The data indicate that POPs have a negative effect on foetal growth. |
format |
Article in Journal/Newspaper |
author |
Hjermitslev, Marie Harthøj Long, Manhai Wielsøe, Maria Bonefeld-Jørgensen, Eva C |
author_facet |
Hjermitslev, Marie Harthøj Long, Manhai Wielsøe, Maria Bonefeld-Jørgensen, Eva C |
author_sort |
Hjermitslev, Marie Harthøj |
title |
Persistent organic pollutants in Greenlandic pregnant women and indices of foetal growth:The ACCEPT study |
title_short |
Persistent organic pollutants in Greenlandic pregnant women and indices of foetal growth:The ACCEPT study |
title_full |
Persistent organic pollutants in Greenlandic pregnant women and indices of foetal growth:The ACCEPT study |
title_fullStr |
Persistent organic pollutants in Greenlandic pregnant women and indices of foetal growth:The ACCEPT study |
title_full_unstemmed |
Persistent organic pollutants in Greenlandic pregnant women and indices of foetal growth:The ACCEPT study |
title_sort |
persistent organic pollutants in greenlandic pregnant women and indices of foetal growth:the accept study |
publishDate |
2020 |
url |
https://pure.au.dk/portal/da/publications/persistent-organic-pollutants-in-greenlandic-pregnant-women-and-indices-of-foetal-growth(40ad56fc-b7d6-47d7-9400-c6c5bf807334).html https://doi.org/10.1016/j.scitotenv.2019.134118 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland greenlandic |
genre_facet |
Greenland greenlandic |
op_source |
Hjermitslev , M H , Long , M , Wielsøe , M & Bonefeld-Jørgensen , E C 2020 , ' Persistent organic pollutants in Greenlandic pregnant women and indices of foetal growth : The ACCEPT study ' , The Science of the Total Environment , vol. 698 , 134118 . https://doi.org/10.1016/j.scitotenv.2019.134118 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.scitotenv.2019.134118 |
container_title |
Science of The Total Environment |
container_volume |
698 |
container_start_page |
134118 |
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1766017751267147776 |