Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9years of age
We examined associations between prenatal exposure to perfluorohexane sulfonic acid (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), and perfluorodecanic acid (PFDA) - and child behaviour (SDQ-total) and hyperactivity (sub-scale) at 5-9years of age in birth cohorts from Green...
Published in: | Hormones and Behavior |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2018
|
Subjects: | |
Online Access: | https://pure.au.dk/portal/da/publications/exposure-to-perfluoroalkyl-substances-during-pregnancy-and-child-behaviour-at-5-to-9years-of-age(32d06514-8baa-4cb1-bb2e-cf704efaf0d3).html https://doi.org/10.1016/j.yhbeh.2017.11.007 |
id |
ftuniaarhuspubl:oai:pure.atira.dk:publications/32d06514-8baa-4cb1-bb2e-cf704efaf0d3 |
---|---|
record_format |
openpolar |
spelling |
ftuniaarhuspubl:oai:pure.atira.dk:publications/32d06514-8baa-4cb1-bb2e-cf704efaf0d3 2023-09-26T15:18:20+02:00 Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9years of age Høyer, Birgit Bjerre Bonde, Jens Peter Ramlau-Hansen, Cecilia Høst Lindh, Christian Tøttenborg, Sandra Søgaard Pedersen, Henning Sloth Toft, Gunnar 2018 https://pure.au.dk/portal/da/publications/exposure-to-perfluoroalkyl-substances-during-pregnancy-and-child-behaviour-at-5-to-9years-of-age(32d06514-8baa-4cb1-bb2e-cf704efaf0d3).html https://doi.org/10.1016/j.yhbeh.2017.11.007 eng eng info:eu-repo/semantics/restrictedAccess Høyer , B B , Bonde , J P , Ramlau-Hansen , C H , Lindh , C , Tøttenborg , S S , Pedersen , H S & Toft , G 2018 , ' Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9years of age ' , Hormones and Behavior . https://doi.org/10.1016/j.yhbeh.2017.11.007 Journal Article article 2018 ftuniaarhuspubl https://doi.org/10.1016/j.yhbeh.2017.11.007 2023-08-30T22:58:07Z We examined associations between prenatal exposure to perfluorohexane sulfonic acid (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), and perfluorodecanic acid (PFDA) - and child behaviour (SDQ-total) and hyperactivity (sub-scale) at 5-9years of age in birth cohorts from Greenland and Ukraine. Pregnancy serum samples (N=1023) were analysed for perfluoroalkyl substances (PFASs) and categorized into tertiles and also used as continuous exposure variables. Problem behaviour and hyperactivity were assessed, using the Strength and Difficulties Questionnaire (SDQ) and categorized as normal/borderline and abnormal. Associations were analysed using multiple logistic and linear regression. High compared to low prenatal PFHxS exposure was associated with 1.16 (95% confidence interval (CI): 0.08; 2.25) point higher SDQ-total (more problem behaviour) in Greenland and 0.80 (CI: 0.06; 1.54) point higher SDQ-total in the combined analyses, whereas no association was present in Ukraine alone. One natural log-unit increase in prenatal PFNA exposure was associated with 0.90 (CI: 0.10; 1.71) points higher SDQ-total in Greenland and 0.72 (CI: 0.13; 1.31) points higher in the combined analysis and no association in Ukraine. Prenatal PFAS exposure was unrelated to problem behaviour (abnormal SDQ-total). In the combined analysis, odds ratio (OR) (CI) for hyperactivity was 1.8 (1.0; 3.2) for one natural log-unit increase in prenatal PFNA and 1.7 (1.0; 3.1) for one natural log-unit increase in prenatal PFDA exposure. Findings are compatible with weak effects on child behaviour of prenatal exposure to some PFASs although spurious results are not entirely unlikely. The associations were strongest in Greenland. Article in Journal/Newspaper Greenland Aarhus University: Research Greenland Hormones and Behavior 101 105 112 |
institution |
Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
Journal Article |
spellingShingle |
Journal Article Høyer, Birgit Bjerre Bonde, Jens Peter Ramlau-Hansen, Cecilia Høst Lindh, Christian Tøttenborg, Sandra Søgaard Pedersen, Henning Sloth Toft, Gunnar Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9years of age |
topic_facet |
Journal Article |
description |
We examined associations between prenatal exposure to perfluorohexane sulfonic acid (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), and perfluorodecanic acid (PFDA) - and child behaviour (SDQ-total) and hyperactivity (sub-scale) at 5-9years of age in birth cohorts from Greenland and Ukraine. Pregnancy serum samples (N=1023) were analysed for perfluoroalkyl substances (PFASs) and categorized into tertiles and also used as continuous exposure variables. Problem behaviour and hyperactivity were assessed, using the Strength and Difficulties Questionnaire (SDQ) and categorized as normal/borderline and abnormal. Associations were analysed using multiple logistic and linear regression. High compared to low prenatal PFHxS exposure was associated with 1.16 (95% confidence interval (CI): 0.08; 2.25) point higher SDQ-total (more problem behaviour) in Greenland and 0.80 (CI: 0.06; 1.54) point higher SDQ-total in the combined analyses, whereas no association was present in Ukraine alone. One natural log-unit increase in prenatal PFNA exposure was associated with 0.90 (CI: 0.10; 1.71) points higher SDQ-total in Greenland and 0.72 (CI: 0.13; 1.31) points higher in the combined analysis and no association in Ukraine. Prenatal PFAS exposure was unrelated to problem behaviour (abnormal SDQ-total). In the combined analysis, odds ratio (OR) (CI) for hyperactivity was 1.8 (1.0; 3.2) for one natural log-unit increase in prenatal PFNA and 1.7 (1.0; 3.1) for one natural log-unit increase in prenatal PFDA exposure. Findings are compatible with weak effects on child behaviour of prenatal exposure to some PFASs although spurious results are not entirely unlikely. The associations were strongest in Greenland. |
format |
Article in Journal/Newspaper |
author |
Høyer, Birgit Bjerre Bonde, Jens Peter Ramlau-Hansen, Cecilia Høst Lindh, Christian Tøttenborg, Sandra Søgaard Pedersen, Henning Sloth Toft, Gunnar |
author_facet |
Høyer, Birgit Bjerre Bonde, Jens Peter Ramlau-Hansen, Cecilia Høst Lindh, Christian Tøttenborg, Sandra Søgaard Pedersen, Henning Sloth Toft, Gunnar |
author_sort |
Høyer, Birgit Bjerre |
title |
Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9years of age |
title_short |
Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9years of age |
title_full |
Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9years of age |
title_fullStr |
Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9years of age |
title_full_unstemmed |
Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9years of age |
title_sort |
exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9years of age |
publishDate |
2018 |
url |
https://pure.au.dk/portal/da/publications/exposure-to-perfluoroalkyl-substances-during-pregnancy-and-child-behaviour-at-5-to-9years-of-age(32d06514-8baa-4cb1-bb2e-cf704efaf0d3).html https://doi.org/10.1016/j.yhbeh.2017.11.007 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Høyer , B B , Bonde , J P , Ramlau-Hansen , C H , Lindh , C , Tøttenborg , S S , Pedersen , H S & Toft , G 2018 , ' Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9years of age ' , Hormones and Behavior . https://doi.org/10.1016/j.yhbeh.2017.11.007 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.yhbeh.2017.11.007 |
container_title |
Hormones and Behavior |
container_volume |
101 |
container_start_page |
105 |
op_container_end_page |
112 |
_version_ |
1778140572523954176 |