Changes in plasma C-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years

• Published in: Blood Coagulation & Fibrinolysis
• Main Authors: Thøgersen, Anna, Nilsson, Torbjörn, Weinehall, Lars, Boman, Kurt, Eliasson, Mats, Hallmans, Göran, Jansson, Jan-Håkan
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2009
• Subjects: Northern Sweden
• Online Access: https://pure.au.dk/portal/da/publications/changes-in-plasma-creactive-protein-and-hemostatic-factors-prior-to-and-after-a-first-myocardial-infarction-with-a-median-followup-time-of-8-years(322448a0-28f9-11de-aee0-000ea68e967b).html; https://doi.org/10.1097/MBC.0b013e32832a5fd1

Udgivelsesdato: 2009 The objective of this study was to determine whether a first myocardial infarction leads to increased plasma levels of hemostatic factors and high sensitive C-reactive protein (hs-CRP) and whether the association between theses biomarkers and myocardial infarction was greater at follow-up compared with baseline. Of more than 36 000 persons screened in northern Sweden, 78 developed a first myocardial infarction (on average 18 months after sampling) in a population-based, prospective, nested patient-referent study. Fifty of these had participated in a follow-up health survey (on average 8 and a half years between surveys) and were sex-matched and age-matched with 56 referents. The mean increases in hs-CRP, tissue plasminogen activator (tPA) mass, plasminogen activator inhibitor-1 mass, and tPA/plasminogen activator inhibitor-1 complex concentration and von Willebrand factor among patients and referents were comparable during follow-up. Conditional logistic regression indicated that hs-CRP was not significantly associated with first myocardial infarction in a univariate analysis, whereas high plasma levels of tPA and creatinine were significantly associated with outcome at baseline and follow-up. tPA/plasminogen activator inhibitor-1 complex was not superior to tPA as a risk marker in this study. A first myocardial infarction did not in this study induce significantly different changes in plasma levels of hs-CRP and hemostatic factors among patients compared with referents during follow-up.