Changes in plasma C-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years
Udgivelsesdato: 2009 The objective of this study was to determine whether a first myocardial infarction leads to increased plasma levels of hemostatic factors and high sensitive C-reactive protein (hs-CRP) and whether the association between theses biomarkers and myocardial infarction was greater at...
Published in: | Blood Coagulation & Fibrinolysis |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/322448a0-28f9-11de-aee0-000ea68e967b 2023-05-15T17:44:50+02:00 Changes in plasma C-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years Thøgersen, Anna Nilsson, Torbjörn Weinehall, Lars Boman, Kurt Eliasson, Mats Hallmans, Göran Jansson, Jan-Håkan 2009 https://pure.au.dk/portal/da/publications/changes-in-plasma-creactive-protein-and-hemostatic-factors-prior-to-and-after-a-first-myocardial-infarction-with-a-median-followup-time-of-8-years(322448a0-28f9-11de-aee0-000ea68e967b).html https://doi.org/10.1097/MBC.0b013e32832a5fd1 eng eng info:eu-repo/semantics/restrictedAccess Thøgersen , A , Nilsson , T , Weinehall , L , Boman , K , Eliasson , M , Hallmans , G & Jansson , J-H 2009 , ' Changes in plasma C-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years ' , Blood Coagulation and Fibrinolysis , vol. 20 , no. 5 , pp. 340-346 . https://doi.org/10.1097/MBC.0b013e32832a5fd1 article 2009 ftuniaarhuspubl https://doi.org/10.1097/MBC.0b013e32832a5fd1 2020-07-18T20:56:30Z Udgivelsesdato: 2009 The objective of this study was to determine whether a first myocardial infarction leads to increased plasma levels of hemostatic factors and high sensitive C-reactive protein (hs-CRP) and whether the association between theses biomarkers and myocardial infarction was greater at follow-up compared with baseline. Of more than 36 000 persons screened in northern Sweden, 78 developed a first myocardial infarction (on average 18 months after sampling) in a population-based, prospective, nested patient-referent study. Fifty of these had participated in a follow-up health survey (on average 8 and a half years between surveys) and were sex-matched and age-matched with 56 referents. The mean increases in hs-CRP, tissue plasminogen activator (tPA) mass, plasminogen activator inhibitor-1 mass, and tPA/plasminogen activator inhibitor-1 complex concentration and von Willebrand factor among patients and referents were comparable during follow-up. Conditional logistic regression indicated that hs-CRP was not significantly associated with first myocardial infarction in a univariate analysis, whereas high plasma levels of tPA and creatinine were significantly associated with outcome at baseline and follow-up. tPA/plasminogen activator inhibitor-1 complex was not superior to tPA as a risk marker in this study. A first myocardial infarction did not in this study induce significantly different changes in plasma levels of hs-CRP and hemostatic factors among patients compared with referents during follow-up. Article in Journal/Newspaper Northern Sweden Aarhus University: Research Blood Coagulation & Fibrinolysis 20 5 340 346 |
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Open Polar |
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Aarhus University: Research |
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ftuniaarhuspubl |
language |
English |
description |
Udgivelsesdato: 2009 The objective of this study was to determine whether a first myocardial infarction leads to increased plasma levels of hemostatic factors and high sensitive C-reactive protein (hs-CRP) and whether the association between theses biomarkers and myocardial infarction was greater at follow-up compared with baseline. Of more than 36 000 persons screened in northern Sweden, 78 developed a first myocardial infarction (on average 18 months after sampling) in a population-based, prospective, nested patient-referent study. Fifty of these had participated in a follow-up health survey (on average 8 and a half years between surveys) and were sex-matched and age-matched with 56 referents. The mean increases in hs-CRP, tissue plasminogen activator (tPA) mass, plasminogen activator inhibitor-1 mass, and tPA/plasminogen activator inhibitor-1 complex concentration and von Willebrand factor among patients and referents were comparable during follow-up. Conditional logistic regression indicated that hs-CRP was not significantly associated with first myocardial infarction in a univariate analysis, whereas high plasma levels of tPA and creatinine were significantly associated with outcome at baseline and follow-up. tPA/plasminogen activator inhibitor-1 complex was not superior to tPA as a risk marker in this study. A first myocardial infarction did not in this study induce significantly different changes in plasma levels of hs-CRP and hemostatic factors among patients compared with referents during follow-up. |
format |
Article in Journal/Newspaper |
author |
Thøgersen, Anna Nilsson, Torbjörn Weinehall, Lars Boman, Kurt Eliasson, Mats Hallmans, Göran Jansson, Jan-Håkan |
spellingShingle |
Thøgersen, Anna Nilsson, Torbjörn Weinehall, Lars Boman, Kurt Eliasson, Mats Hallmans, Göran Jansson, Jan-Håkan Changes in plasma C-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years |
author_facet |
Thøgersen, Anna Nilsson, Torbjörn Weinehall, Lars Boman, Kurt Eliasson, Mats Hallmans, Göran Jansson, Jan-Håkan |
author_sort |
Thøgersen, Anna |
title |
Changes in plasma C-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years |
title_short |
Changes in plasma C-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years |
title_full |
Changes in plasma C-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years |
title_fullStr |
Changes in plasma C-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years |
title_full_unstemmed |
Changes in plasma C-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years |
title_sort |
changes in plasma c-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years |
publishDate |
2009 |
url |
https://pure.au.dk/portal/da/publications/changes-in-plasma-creactive-protein-and-hemostatic-factors-prior-to-and-after-a-first-myocardial-infarction-with-a-median-followup-time-of-8-years(322448a0-28f9-11de-aee0-000ea68e967b).html https://doi.org/10.1097/MBC.0b013e32832a5fd1 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Thøgersen , A , Nilsson , T , Weinehall , L , Boman , K , Eliasson , M , Hallmans , G & Jansson , J-H 2009 , ' Changes in plasma C-reactive protein and hemostatic factors prior to and after a first myocardial infarction with a median follow-up time of 8 years ' , Blood Coagulation and Fibrinolysis , vol. 20 , no. 5 , pp. 340-346 . https://doi.org/10.1097/MBC.0b013e32832a5fd1 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1097/MBC.0b013e32832a5fd1 |
container_title |
Blood Coagulation & Fibrinolysis |
container_volume |
20 |
container_issue |
5 |
container_start_page |
340 |
op_container_end_page |
346 |
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1766147125654061056 |