Physiologically based pharmacokinetic modeling of POPs in Greenlanders

• Published in: Environment International
• Main Authors: Sonne, Christian, Gustavson, Kim, Rigét, Frank F, Dietz, Rune, Krüger, Tanja, Bonefeld-Jørgensen, Eva C
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2014
• Subjects: Arctic; Greenland; Nuuk; Qaanaaq; Qeqertarsuaq; greenlander*; greenlandic; inuit; inuits; Narsaq
• Online Access: https://pure.au.dk/portal/da/publications/physiologically-based-pharmacokinetic-modeling-of-pops-in-greenlanders(2ae567a8-ded4-42fd-b3d6-da28dfb44c23).html; https://doi.org/10.1016/j.envint.2013.12.006

Human exposure to persistent organic pollutants (POPs) and the potential health impact in the Arctic far from the emission sources have been highlighted in numerous studies. As a supplement to human POP biomonitoring studies, a physiologically based pharmacokinetic (PBPK) model was set up to estimate the fate of POPs in Greenlandic Inuit's liver, blood, muscle and adipose tissue following long-term exposure to traditional Greenlandic diet. The PBPK model described metabolism, excretion and POP accumulation on the basis of their physicochemical properties and metabolic rates in the organisms. Basic correlations between chemically analyzed blood POP concentrations and calculated daily POP intake from food questionnaire of 118 middle age (18-35years) Greenlandic Inuits from four cities in West Greenland (Qaanaaq: n=40; Qeqertarsuaq: n=36; Nuuk: n=20; Narsaq: n=22) taken during 2003 to 2006 were analyzed. The dietary items included were polar bear, caribou, musk oxen, several marine species such as whales, seals, bird and fish as well as imported food. The contaminant concentrations of the dietary items as well as their chemical properties, uptake, biotransformation and excretion allowed us to estimate the POP concentration in liver, blood, muscle and adipose tissue following long-term exposure to the traditional Greenlandic diet using the PBPK model. Significant correlations were found between chemically analyzed POP blood concentrations and calculated daily intake of POPs for Qeqertarsuaq, Nuuk and Narsaq Inuit but not for the northernmost settlement Qaanaaq, probably because the highest blood POP level was found in this district which might mask the interview-based POP calculations. Despite the large variation in circulating blood POP concentrations, the PBPK model predicted blood concentrations of a factor 2-3 within the actual measured values. Moreover, the PBPK model showed that estimated blood POP concentration increased significantly after consumption of meals. For individuals who had a high internal burden ...