Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries
Udgivelsesdato: 2003-Oct-15 BACKGROUND: Studies from various countries have found an increasing incidence of childhood leukemia in recent decades. To characterize time trends in the age- and sex-specific incidence of childhood acute leukemia during the last 20 years in the Nordic countries, we analy...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2003
|
Subjects: | |
Online Access: | https://pure.au.dk/portal/da/publications/age-and-sexspecific-incidence-of-childhood-leukemia-by-immunophenotype-in-the-nordic-countries(22d20410-f81a-11dd-8f9a-000ea68e967b).html |
id |
ftuniaarhuspubl:oai:pure.atira.dk:publications/22d20410-f81a-11dd-8f9a-000ea68e967b |
---|---|
record_format |
openpolar |
spelling |
ftuniaarhuspubl:oai:pure.atira.dk:publications/22d20410-f81a-11dd-8f9a-000ea68e967b 2023-05-15T16:52:48+02:00 Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries Hjalgrim, Lisa Lyngsie Rostgaard, Klaus Schmiegelow, Kjeld Söderhäll, Stefan Kolmannskog, Svein Vettenranta, Kim Kristinsson, Jon Clausen, Niels Melbye, Mads Hjalgrim, Henrik Gustafsson, Göran 2003 https://pure.au.dk/portal/da/publications/age-and-sexspecific-incidence-of-childhood-leukemia-by-immunophenotype-in-the-nordic-countries(22d20410-f81a-11dd-8f9a-000ea68e967b).html eng eng info:eu-repo/semantics/restrictedAccess Hjalgrim , L L , Rostgaard , K , Schmiegelow , K , Söderhäll , S , Kolmannskog , S , Vettenranta , K , Kristinsson , J , Clausen , N , Melbye , M , Hjalgrim , H & Gustafsson , G 2003 , ' Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries ' , National Cancer Institute. Journal (Print) , vol. 95 , no. 20 , pp. 1539-44 . Adolescent Age Distribution Child Preschool Female Finland Humans Iceland Immunophenotyping Incidence Infant Newborn Leukemia Myeloid Acute Male Poisson Distribution Precursor Cell Lymphoblastic Leukemia-Lymphoma Scandinavia Sex Distribution article 2003 ftuniaarhuspubl 2020-07-18T20:55:09Z Udgivelsesdato: 2003-Oct-15 BACKGROUND: Studies from various countries have found an increasing incidence of childhood leukemia in recent decades. To characterize time trends in the age- and sex-specific incidence of childhood acute leukemia during the last 20 years in the Nordic countries, we analyzed a large set of population-based data from the Nordic Society of Paediatric Haematology and Oncology (NOPHO) in their acute leukemia database covering a population of approximately 5 million children aged 0-14 years. METHODS: Temporal trends in acute myeloid leukemia and acute lymphoblastic leukemia incidence rates overall and for acute lymphoblastic leukemia immunophenotypes and for specific age groups were analyzed by Poisson regression adjusting for age, sex, and country. All statistical tests were two-sided. RESULTS: We identified 1595 girls and 1859 boys diagnosed with acute lymphoblastic leukemia between January 1, 1982, and December 31, 2001, and 260 girls and 224 boys diagnosed with de novo acute myeloid leukemia between January 1, 1985, and December 31, 2001. No statistically significant change was seen in the overall incidence rate for acute lymphoblastic leukemia during the 20-year study (annual change = 0.22%, 95% confidence interval [CI] = -0.36% to 0.80%). The incidence rate of B-precursor acute lymphoblastic leukemia remained unchanged (annual change = 0.30%, 95% CI = -0.57% to 1.18%) from January 1, 1986, through December 31, 2001. A somewhat lower incidence in the first years of the study period indicated an early increasing incidence of B-precursor acute lymphoblastic leukemia that corresponded to a simultaneous decreasing incidence of unclassified acute lymphoblastic leukemia. Incidences of T-cell acute lymphoblastic leukemia (annual change = 1.55%, 95% CI = -1.14% to 4.31%) and acute myeloid leukemia (annual change = 0.58%, 95% CI = -1.24% to 2.44%) were stable during the study period. CONCLUSION: Incidences of acute myeloid leukemia overall, acute lymphoblastic leukemia overall, and specific acute lymphoblastic leukemia immunophenotypes have been stable in the Nordic countries over the past two decades. Article in Journal/Newspaper Iceland Aarhus University: Research |
institution |
Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
Adolescent Age Distribution Child Preschool Female Finland Humans Iceland Immunophenotyping Incidence Infant Newborn Leukemia Myeloid Acute Male Poisson Distribution Precursor Cell Lymphoblastic Leukemia-Lymphoma Scandinavia Sex Distribution |
spellingShingle |
Adolescent Age Distribution Child Preschool Female Finland Humans Iceland Immunophenotyping Incidence Infant Newborn Leukemia Myeloid Acute Male Poisson Distribution Precursor Cell Lymphoblastic Leukemia-Lymphoma Scandinavia Sex Distribution Hjalgrim, Lisa Lyngsie Rostgaard, Klaus Schmiegelow, Kjeld Söderhäll, Stefan Kolmannskog, Svein Vettenranta, Kim Kristinsson, Jon Clausen, Niels Melbye, Mads Hjalgrim, Henrik Gustafsson, Göran Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries |
topic_facet |
Adolescent Age Distribution Child Preschool Female Finland Humans Iceland Immunophenotyping Incidence Infant Newborn Leukemia Myeloid Acute Male Poisson Distribution Precursor Cell Lymphoblastic Leukemia-Lymphoma Scandinavia Sex Distribution |
description |
Udgivelsesdato: 2003-Oct-15 BACKGROUND: Studies from various countries have found an increasing incidence of childhood leukemia in recent decades. To characterize time trends in the age- and sex-specific incidence of childhood acute leukemia during the last 20 years in the Nordic countries, we analyzed a large set of population-based data from the Nordic Society of Paediatric Haematology and Oncology (NOPHO) in their acute leukemia database covering a population of approximately 5 million children aged 0-14 years. METHODS: Temporal trends in acute myeloid leukemia and acute lymphoblastic leukemia incidence rates overall and for acute lymphoblastic leukemia immunophenotypes and for specific age groups were analyzed by Poisson regression adjusting for age, sex, and country. All statistical tests were two-sided. RESULTS: We identified 1595 girls and 1859 boys diagnosed with acute lymphoblastic leukemia between January 1, 1982, and December 31, 2001, and 260 girls and 224 boys diagnosed with de novo acute myeloid leukemia between January 1, 1985, and December 31, 2001. No statistically significant change was seen in the overall incidence rate for acute lymphoblastic leukemia during the 20-year study (annual change = 0.22%, 95% confidence interval [CI] = -0.36% to 0.80%). The incidence rate of B-precursor acute lymphoblastic leukemia remained unchanged (annual change = 0.30%, 95% CI = -0.57% to 1.18%) from January 1, 1986, through December 31, 2001. A somewhat lower incidence in the first years of the study period indicated an early increasing incidence of B-precursor acute lymphoblastic leukemia that corresponded to a simultaneous decreasing incidence of unclassified acute lymphoblastic leukemia. Incidences of T-cell acute lymphoblastic leukemia (annual change = 1.55%, 95% CI = -1.14% to 4.31%) and acute myeloid leukemia (annual change = 0.58%, 95% CI = -1.24% to 2.44%) were stable during the study period. CONCLUSION: Incidences of acute myeloid leukemia overall, acute lymphoblastic leukemia overall, and specific acute lymphoblastic leukemia immunophenotypes have been stable in the Nordic countries over the past two decades. |
format |
Article in Journal/Newspaper |
author |
Hjalgrim, Lisa Lyngsie Rostgaard, Klaus Schmiegelow, Kjeld Söderhäll, Stefan Kolmannskog, Svein Vettenranta, Kim Kristinsson, Jon Clausen, Niels Melbye, Mads Hjalgrim, Henrik Gustafsson, Göran |
author_facet |
Hjalgrim, Lisa Lyngsie Rostgaard, Klaus Schmiegelow, Kjeld Söderhäll, Stefan Kolmannskog, Svein Vettenranta, Kim Kristinsson, Jon Clausen, Niels Melbye, Mads Hjalgrim, Henrik Gustafsson, Göran |
author_sort |
Hjalgrim, Lisa Lyngsie |
title |
Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries |
title_short |
Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries |
title_full |
Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries |
title_fullStr |
Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries |
title_full_unstemmed |
Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries |
title_sort |
age- and sex-specific incidence of childhood leukemia by immunophenotype in the nordic countries |
publishDate |
2003 |
url |
https://pure.au.dk/portal/da/publications/age-and-sexspecific-incidence-of-childhood-leukemia-by-immunophenotype-in-the-nordic-countries(22d20410-f81a-11dd-8f9a-000ea68e967b).html |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Hjalgrim , L L , Rostgaard , K , Schmiegelow , K , Söderhäll , S , Kolmannskog , S , Vettenranta , K , Kristinsson , J , Clausen , N , Melbye , M , Hjalgrim , H & Gustafsson , G 2003 , ' Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries ' , National Cancer Institute. Journal (Print) , vol. 95 , no. 20 , pp. 1539-44 . |
op_rights |
info:eu-repo/semantics/restrictedAccess |
_version_ |
1766043208041627648 |