Nationwide study on antipsychotic polypharmacy among forensic psychiatric patients
This nationwide retrospective cross-sectional study examines the prevalence of antipsychotic polypharmacy (APP) and demographic, forensic, and clinical factors associated with its practice among Greenlandic forensic psychiatric patients. We collected data from electronic patient files, court documen...
Published in: | International Journal of Circumpolar Health |
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Language: | English |
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2023
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Online Access: | https://pure.au.dk/portal/da/publications/nationwide-study-on-antipsychotic-polypharmacy-among-forensic-psychiatric-patients(19c90866-31cd-477a-aee0-3ff1403c8ce9).html https://doi.org/10.1080/22423982.2023.2218654 http://www.scopus.com/inward/record.url?scp=85161661172&partnerID=8YFLogxK |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/19c90866-31cd-477a-aee0-3ff1403c8ce9 2023-12-31T10:05:57+01:00 Nationwide study on antipsychotic polypharmacy among forensic psychiatric patients Lassen, Stine Heintz, Thale Pedersen, Tilde Jentz, Christian Nathanielsen, Naaja Heilmann, Parnuna Sørensen, Lisbeth Uhrskov 2023-12 https://pure.au.dk/portal/da/publications/nationwide-study-on-antipsychotic-polypharmacy-among-forensic-psychiatric-patients(19c90866-31cd-477a-aee0-3ff1403c8ce9).html https://doi.org/10.1080/22423982.2023.2218654 http://www.scopus.com/inward/record.url?scp=85161661172&partnerID=8YFLogxK eng eng https://pure.au.dk/portal/da/publications/nationwide-study-on-antipsychotic-polypharmacy-among-forensic-psychiatric-patients(19c90866-31cd-477a-aee0-3ff1403c8ce9).html info:eu-repo/semantics/openAccess Lassen , S , Heintz , T , Pedersen , T , Jentz , C , Nathanielsen , N , Heilmann , P & Sørensen , L U 2023 , ' Nationwide study on antipsychotic polypharmacy among forensic psychiatric patients ' , International Journal of Circumpolar Health , vol. 82 , no. 1 , 2218654 . https://doi.org/10.1080/22423982.2023.2218654 antipsychotics circumpolar forensic psychiatry polypharmacy schizophrenia article 2023 ftuniaarhuspubl https://doi.org/10.1080/22423982.2023.2218654 2023-12-07T00:06:20Z This nationwide retrospective cross-sectional study examines the prevalence of antipsychotic polypharmacy (APP) and demographic, forensic, and clinical factors associated with its practice among Greenlandic forensic psychiatric patients. We collected data from electronic patient files, court documents, and forensic psychiatric assessments. We defined APP as two or more concurrent prescriptions of antipsychotic medication. The study population of 74 patients had a mean age of 41.4 years, and 61 were men. All included patients had either schizophrenia or another ICD-10 F2-diagnosis. We used unpaired t-tests and Chi2 or Fisher's exact test. The prevalence of APP was 35% (n = 26), and there was a significant association between APP and a prescription of clozapine (Chi2, p = 0.010), olanzapine (Fisher's test, p = 0.003), and aripiprazole (Fisher's test, p = 0.013). Furthermore, we found a significant association between APP and prescription of a first-generation antipsychotic (FGA) (Chi2, p = 0.011). Despite recommendations in guidelines, the use of APP is common practice. The majority of forensic psychiatric patients suffer from severe psychiatric disorders, often with other comorbidities, including substance use disorder. The severity and complexity in mental health render forensic psychiatric patients at high risk of APP treatment. Further knowledge on APP use is crucial to secure and further improve the psychopharmacological treatment for this group of patients. Article in Journal/Newspaper Circumpolar Health greenlandic International Journal of Circumpolar Health Aarhus University: Research International Journal of Circumpolar Health 82 1 |
institution |
Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
antipsychotics circumpolar forensic psychiatry polypharmacy schizophrenia |
spellingShingle |
antipsychotics circumpolar forensic psychiatry polypharmacy schizophrenia Lassen, Stine Heintz, Thale Pedersen, Tilde Jentz, Christian Nathanielsen, Naaja Heilmann, Parnuna Sørensen, Lisbeth Uhrskov Nationwide study on antipsychotic polypharmacy among forensic psychiatric patients |
topic_facet |
antipsychotics circumpolar forensic psychiatry polypharmacy schizophrenia |
description |
This nationwide retrospective cross-sectional study examines the prevalence of antipsychotic polypharmacy (APP) and demographic, forensic, and clinical factors associated with its practice among Greenlandic forensic psychiatric patients. We collected data from electronic patient files, court documents, and forensic psychiatric assessments. We defined APP as two or more concurrent prescriptions of antipsychotic medication. The study population of 74 patients had a mean age of 41.4 years, and 61 were men. All included patients had either schizophrenia or another ICD-10 F2-diagnosis. We used unpaired t-tests and Chi2 or Fisher's exact test. The prevalence of APP was 35% (n = 26), and there was a significant association between APP and a prescription of clozapine (Chi2, p = 0.010), olanzapine (Fisher's test, p = 0.003), and aripiprazole (Fisher's test, p = 0.013). Furthermore, we found a significant association between APP and prescription of a first-generation antipsychotic (FGA) (Chi2, p = 0.011). Despite recommendations in guidelines, the use of APP is common practice. The majority of forensic psychiatric patients suffer from severe psychiatric disorders, often with other comorbidities, including substance use disorder. The severity and complexity in mental health render forensic psychiatric patients at high risk of APP treatment. Further knowledge on APP use is crucial to secure and further improve the psychopharmacological treatment for this group of patients. |
format |
Article in Journal/Newspaper |
author |
Lassen, Stine Heintz, Thale Pedersen, Tilde Jentz, Christian Nathanielsen, Naaja Heilmann, Parnuna Sørensen, Lisbeth Uhrskov |
author_facet |
Lassen, Stine Heintz, Thale Pedersen, Tilde Jentz, Christian Nathanielsen, Naaja Heilmann, Parnuna Sørensen, Lisbeth Uhrskov |
author_sort |
Lassen, Stine |
title |
Nationwide study on antipsychotic polypharmacy among forensic psychiatric patients |
title_short |
Nationwide study on antipsychotic polypharmacy among forensic psychiatric patients |
title_full |
Nationwide study on antipsychotic polypharmacy among forensic psychiatric patients |
title_fullStr |
Nationwide study on antipsychotic polypharmacy among forensic psychiatric patients |
title_full_unstemmed |
Nationwide study on antipsychotic polypharmacy among forensic psychiatric patients |
title_sort |
nationwide study on antipsychotic polypharmacy among forensic psychiatric patients |
publishDate |
2023 |
url |
https://pure.au.dk/portal/da/publications/nationwide-study-on-antipsychotic-polypharmacy-among-forensic-psychiatric-patients(19c90866-31cd-477a-aee0-3ff1403c8ce9).html https://doi.org/10.1080/22423982.2023.2218654 http://www.scopus.com/inward/record.url?scp=85161661172&partnerID=8YFLogxK |
genre |
Circumpolar Health greenlandic International Journal of Circumpolar Health |
genre_facet |
Circumpolar Health greenlandic International Journal of Circumpolar Health |
op_source |
Lassen , S , Heintz , T , Pedersen , T , Jentz , C , Nathanielsen , N , Heilmann , P & Sørensen , L U 2023 , ' Nationwide study on antipsychotic polypharmacy among forensic psychiatric patients ' , International Journal of Circumpolar Health , vol. 82 , no. 1 , 2218654 . https://doi.org/10.1080/22423982.2023.2218654 |
op_relation |
https://pure.au.dk/portal/da/publications/nationwide-study-on-antipsychotic-polypharmacy-among-forensic-psychiatric-patients(19c90866-31cd-477a-aee0-3ff1403c8ce9).html |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1080/22423982.2023.2218654 |
container_title |
International Journal of Circumpolar Health |
container_volume |
82 |
container_issue |
1 |
_version_ |
1786837694536482816 |