The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos
Hibernation is an adaptation that helps many animals to conserve energy during food shortage in winter. Brown bears double their fat depots during summer and use these stored lipids during hibernation. Although bears seasonally become obese, they remain metabolically healthy. We analyzed the microbi...
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ftuniaarhuspubl:oai:pure.atira.dk:publications/0a53ab19-bb4e-4bd2-95dc-ddd520b60eb3 2023-05-15T18:42:02+02:00 The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos Sommer, Felix Ståhlman, Marcus Ilkayeva, Olga Arnemo, Jon M. Kindberg, Jonas Josefsson, Johan Newgard, Christopher B. Fröbert, Ole Bäckhed, Fredrik 2016-02-23 https://pure.au.dk/portal/da/publications/the-gut-microbiota-modulates-energy-metabolism-in-the-hibernating-brown-bear-ursus-arctos(0a53ab19-bb4e-4bd2-95dc-ddd520b60eb3).html https://doi.org/10.1016/j.celrep.2016.01.026 http://www.scopus.com/inward/record.url?scp=84959156875&partnerID=8YFLogxK eng eng info:eu-repo/semantics/openAccess Sommer , F , Ståhlman , M , Ilkayeva , O , Arnemo , J M , Kindberg , J , Josefsson , J , Newgard , C B , Fröbert , O & Bäckhed , F 2016 , ' The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos ' , Cell Reports , vol. 14 , no. 7 , pp. 1655-1661 . https://doi.org/10.1016/j.celrep.2016.01.026 Brown bear Hibernation Metabolism Microbiota Obesity article 2016 ftuniaarhuspubl https://doi.org/10.1016/j.celrep.2016.01.026 2023-03-01T23:56:57Z Hibernation is an adaptation that helps many animals to conserve energy during food shortage in winter. Brown bears double their fat depots during summer and use these stored lipids during hibernation. Although bears seasonally become obese, they remain metabolically healthy. We analyzed the microbiota of free-ranging brown bears during their active phase and hibernation. Compared to the active phase, hibernation microbiota had reduced diversity, reduced levels of Firmicutes and Actinobacteria, and increased levels of Bacteroidetes. Several metabolites involved in lipid metabolism, including triglycerides, cholesterol, and bile acids, were also affected by hibernation. Transplantation of the bear microbiota from summer and winter to germ-free mice transferred some of the seasonal metabolic features and demonstrated that the summer microbiota promoted adiposity without impairing glucose tolerance, suggesting that seasonal variation in the microbiota may contribute to host energy metabolism in the hibernating brown bear. Article in Journal/Newspaper Ursus arctos Aarhus University: Research Cell Reports 14 7 1655 1661 |
institution |
Open Polar |
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Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
Brown bear Hibernation Metabolism Microbiota Obesity |
spellingShingle |
Brown bear Hibernation Metabolism Microbiota Obesity Sommer, Felix Ståhlman, Marcus Ilkayeva, Olga Arnemo, Jon M. Kindberg, Jonas Josefsson, Johan Newgard, Christopher B. Fröbert, Ole Bäckhed, Fredrik The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos |
topic_facet |
Brown bear Hibernation Metabolism Microbiota Obesity |
description |
Hibernation is an adaptation that helps many animals to conserve energy during food shortage in winter. Brown bears double their fat depots during summer and use these stored lipids during hibernation. Although bears seasonally become obese, they remain metabolically healthy. We analyzed the microbiota of free-ranging brown bears during their active phase and hibernation. Compared to the active phase, hibernation microbiota had reduced diversity, reduced levels of Firmicutes and Actinobacteria, and increased levels of Bacteroidetes. Several metabolites involved in lipid metabolism, including triglycerides, cholesterol, and bile acids, were also affected by hibernation. Transplantation of the bear microbiota from summer and winter to germ-free mice transferred some of the seasonal metabolic features and demonstrated that the summer microbiota promoted adiposity without impairing glucose tolerance, suggesting that seasonal variation in the microbiota may contribute to host energy metabolism in the hibernating brown bear. |
format |
Article in Journal/Newspaper |
author |
Sommer, Felix Ståhlman, Marcus Ilkayeva, Olga Arnemo, Jon M. Kindberg, Jonas Josefsson, Johan Newgard, Christopher B. Fröbert, Ole Bäckhed, Fredrik |
author_facet |
Sommer, Felix Ståhlman, Marcus Ilkayeva, Olga Arnemo, Jon M. Kindberg, Jonas Josefsson, Johan Newgard, Christopher B. Fröbert, Ole Bäckhed, Fredrik |
author_sort |
Sommer, Felix |
title |
The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos |
title_short |
The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos |
title_full |
The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos |
title_fullStr |
The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos |
title_full_unstemmed |
The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos |
title_sort |
gut microbiota modulates energy metabolism in the hibernating brown bear ursus arctos |
publishDate |
2016 |
url |
https://pure.au.dk/portal/da/publications/the-gut-microbiota-modulates-energy-metabolism-in-the-hibernating-brown-bear-ursus-arctos(0a53ab19-bb4e-4bd2-95dc-ddd520b60eb3).html https://doi.org/10.1016/j.celrep.2016.01.026 http://www.scopus.com/inward/record.url?scp=84959156875&partnerID=8YFLogxK |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
Sommer , F , Ståhlman , M , Ilkayeva , O , Arnemo , J M , Kindberg , J , Josefsson , J , Newgard , C B , Fröbert , O & Bäckhed , F 2016 , ' The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos ' , Cell Reports , vol. 14 , no. 7 , pp. 1655-1661 . https://doi.org/10.1016/j.celrep.2016.01.026 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.celrep.2016.01.026 |
container_title |
Cell Reports |
container_volume |
14 |
container_issue |
7 |
container_start_page |
1655 |
op_container_end_page |
1661 |
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1766231622017875968 |