Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations
BACKGROUND: Epidemiological studies on the association between maternal exposure to persistent organic pollutants (POPs) and fetal growth alteration report inconsistent findings which weights in favor of additional studies. METHODS: Blood samples were collected from interviewed pregnant women in Gre...
Published in: | Environmental Health |
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Main Authors: | , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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2010
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Online Access: | https://pure.au.dk/portal/da/publications/association-of-maternal-serum-concentrations-of-22-4455hexachlorobiphenyl-cb153-and-11dichloro22bis-pchlorophenylethylene-ppdde-levels-with-birth-weight-gestational-age-and-preterm-births-in-inuit-and-european-populations(07379726-27f1-45ba-8e5f-c9e3aa8e6b21).html https://doi.org/10.1186/1476-069X-9-56 |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/07379726-27f1-45ba-8e5f-c9e3aa8e6b21 |
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openpolar |
institution |
Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
Biological Markers Birth Weight Cohort Studies Dichlorodiphenyl Dichloroethylene Environmental Pollutants European Continental Ancestry Group Female Gestational Age Greenland Humans Hydrocarbons Chlorinated Infant Newborn Premature Inuits Male Maternal Exposure Poland Pregnancy Pregnant Women Prenatal Exposure Delayed Effects Ukraine |
spellingShingle |
Biological Markers Birth Weight Cohort Studies Dichlorodiphenyl Dichloroethylene Environmental Pollutants European Continental Ancestry Group Female Gestational Age Greenland Humans Hydrocarbons Chlorinated Infant Newborn Premature Inuits Male Maternal Exposure Poland Pregnancy Pregnant Women Prenatal Exposure Delayed Effects Ukraine Wojtyniak, Bogdan J Rabczenko, Daniel Jönsson, Bo A G Zvezday, Valentyna Pedersen, Henning S Rylander, Lars Toft, Gunnar Ludwicki, Jan K Góralczyk, Katarzyna Lesovaya, Anna Hagmar, Lars Bonde, Jens Peter Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations |
topic_facet |
Biological Markers Birth Weight Cohort Studies Dichlorodiphenyl Dichloroethylene Environmental Pollutants European Continental Ancestry Group Female Gestational Age Greenland Humans Hydrocarbons Chlorinated Infant Newborn Premature Inuits Male Maternal Exposure Poland Pregnancy Pregnant Women Prenatal Exposure Delayed Effects Ukraine |
description |
BACKGROUND: Epidemiological studies on the association between maternal exposure to persistent organic pollutants (POPs) and fetal growth alteration report inconsistent findings which weights in favor of additional studies. METHODS: Blood samples were collected from interviewed pregnant women in Greenland (572), Kharkiv (611) and Warsaw (258) and were analyzed for CB-153 and p,p'-DDE by gas chromatography-mass spectrometry. Data on birth weight, gestational age and preterm birth were obtained for 1322 singleton live births. We examined the association between natural log-transformed serum POPs concentration and birth weight and gestational age using multiple linear regression and the association with prematurity using logistic regression controlling for potential confounding factors. RESULTS: The median serum concentrations of CB-153 and p,p'-DDE were for Inuit mothers 105.6 and 298.9, for Kharkiv mothers 27.0 and 645.4 and for Warsaw mothers 10.7 and 365.2 ng/g lipids, respectively. Increase in CB-153 concentration by one unit on the log scale in Inuit mothers serum was associated with significant decrease in infant birth weight of -59 g and gestational age by -0.2 week. Decreases observed in the cohorts in Kharkiv (-10 g and -0.1 week) and in Warsaw (-49 g and -0.2 week) were not statistically significant. Increase in p,p'-DDE concentration by one unit on the log scale was associated with a statistically significant decrease in infant birth weight of -39.4 g and -104.3 g and shortening of gestational age of -0.2 week and -0.6 week in the Inuit and Warsaw cohorts, respectively. In the Kharkiv cohort decrease in birth weight (-30.5 g) was not significant, however a shortening of gestational age of -0.2 week per increase in p,p'-DDE concentration by one unit on the log scale was of the borderline significance. There was no significant association between CB-153 and p,p'-DDE concentrations and risk of preterm birth however, in all cohorts the odds ratio was above 1. CONCLUSIONS: In utero exposure to POPs may reduce birth weight and gestational age of newborns however, new insights as to why results vary across studies were not apparent. |
format |
Article in Journal/Newspaper |
author |
Wojtyniak, Bogdan J Rabczenko, Daniel Jönsson, Bo A G Zvezday, Valentyna Pedersen, Henning S Rylander, Lars Toft, Gunnar Ludwicki, Jan K Góralczyk, Katarzyna Lesovaya, Anna Hagmar, Lars Bonde, Jens Peter |
author_facet |
Wojtyniak, Bogdan J Rabczenko, Daniel Jönsson, Bo A G Zvezday, Valentyna Pedersen, Henning S Rylander, Lars Toft, Gunnar Ludwicki, Jan K Góralczyk, Katarzyna Lesovaya, Anna Hagmar, Lars Bonde, Jens Peter |
author_sort |
Wojtyniak, Bogdan J |
title |
Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations |
title_short |
Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations |
title_full |
Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations |
title_fullStr |
Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations |
title_full_unstemmed |
Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations |
title_sort |
association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (cb-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-dde) levels with birth weight, gestational age and preterm births in inuit and european populations |
publishDate |
2010 |
url |
https://pure.au.dk/portal/da/publications/association-of-maternal-serum-concentrations-of-22-4455hexachlorobiphenyl-cb153-and-11dichloro22bis-pchlorophenylethylene-ppdde-levels-with-birth-weight-gestational-age-and-preterm-births-in-inuit-and-european-populations(07379726-27f1-45ba-8e5f-c9e3aa8e6b21).html https://doi.org/10.1186/1476-069X-9-56 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit inuits |
genre_facet |
Greenland inuit inuits |
op_source |
Wojtyniak , B J , Rabczenko , D , Jönsson , B A G , Zvezday , V , Pedersen , H S , Rylander , L , Toft , G , Ludwicki , J K , Góralczyk , K , Lesovaya , A , Hagmar , L , Bonde , J P & INUENDO research group 2010 , ' Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations ' , Environmental Health: A Global Access Science Source , vol. 9 , pp. 56 . https://doi.org/10.1186/1476-069X-9-56 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1186/1476-069X-9-56 |
container_title |
Environmental Health |
container_volume |
9 |
container_issue |
1 |
_version_ |
1766018967817682944 |
spelling |
ftuniaarhuspubl:oai:pure.atira.dk:publications/07379726-27f1-45ba-8e5f-c9e3aa8e6b21 2023-05-15T16:29:16+02:00 Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations Wojtyniak, Bogdan J Rabczenko, Daniel Jönsson, Bo A G Zvezday, Valentyna Pedersen, Henning S Rylander, Lars Toft, Gunnar Ludwicki, Jan K Góralczyk, Katarzyna Lesovaya, Anna Hagmar, Lars Bonde, Jens Peter 2010 https://pure.au.dk/portal/da/publications/association-of-maternal-serum-concentrations-of-22-4455hexachlorobiphenyl-cb153-and-11dichloro22bis-pchlorophenylethylene-ppdde-levels-with-birth-weight-gestational-age-and-preterm-births-in-inuit-and-european-populations(07379726-27f1-45ba-8e5f-c9e3aa8e6b21).html https://doi.org/10.1186/1476-069X-9-56 eng eng info:eu-repo/semantics/restrictedAccess Wojtyniak , B J , Rabczenko , D , Jönsson , B A G , Zvezday , V , Pedersen , H S , Rylander , L , Toft , G , Ludwicki , J K , Góralczyk , K , Lesovaya , A , Hagmar , L , Bonde , J P & INUENDO research group 2010 , ' Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations ' , Environmental Health: A Global Access Science Source , vol. 9 , pp. 56 . https://doi.org/10.1186/1476-069X-9-56 Biological Markers Birth Weight Cohort Studies Dichlorodiphenyl Dichloroethylene Environmental Pollutants European Continental Ancestry Group Female Gestational Age Greenland Humans Hydrocarbons Chlorinated Infant Newborn Premature Inuits Male Maternal Exposure Poland Pregnancy Pregnant Women Prenatal Exposure Delayed Effects Ukraine article 2010 ftuniaarhuspubl https://doi.org/10.1186/1476-069X-9-56 2020-07-18T21:33:37Z BACKGROUND: Epidemiological studies on the association between maternal exposure to persistent organic pollutants (POPs) and fetal growth alteration report inconsistent findings which weights in favor of additional studies. METHODS: Blood samples were collected from interviewed pregnant women in Greenland (572), Kharkiv (611) and Warsaw (258) and were analyzed for CB-153 and p,p'-DDE by gas chromatography-mass spectrometry. Data on birth weight, gestational age and preterm birth were obtained for 1322 singleton live births. We examined the association between natural log-transformed serum POPs concentration and birth weight and gestational age using multiple linear regression and the association with prematurity using logistic regression controlling for potential confounding factors. RESULTS: The median serum concentrations of CB-153 and p,p'-DDE were for Inuit mothers 105.6 and 298.9, for Kharkiv mothers 27.0 and 645.4 and for Warsaw mothers 10.7 and 365.2 ng/g lipids, respectively. Increase in CB-153 concentration by one unit on the log scale in Inuit mothers serum was associated with significant decrease in infant birth weight of -59 g and gestational age by -0.2 week. Decreases observed in the cohorts in Kharkiv (-10 g and -0.1 week) and in Warsaw (-49 g and -0.2 week) were not statistically significant. Increase in p,p'-DDE concentration by one unit on the log scale was associated with a statistically significant decrease in infant birth weight of -39.4 g and -104.3 g and shortening of gestational age of -0.2 week and -0.6 week in the Inuit and Warsaw cohorts, respectively. In the Kharkiv cohort decrease in birth weight (-30.5 g) was not significant, however a shortening of gestational age of -0.2 week per increase in p,p'-DDE concentration by one unit on the log scale was of the borderline significance. There was no significant association between CB-153 and p,p'-DDE concentrations and risk of preterm birth however, in all cohorts the odds ratio was above 1. CONCLUSIONS: In utero exposure to POPs may reduce birth weight and gestational age of newborns however, new insights as to why results vary across studies were not apparent. Article in Journal/Newspaper Greenland inuit inuits Aarhus University: Research Greenland Environmental Health 9 1 |