Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men
Recently the dogma that there is an inverse linear association between androgen receptor (AR) CAG and GGN polymorphisms and receptor activity has been challenged. We analysed the pattern of association between 21 male reproductive phenotypes and AR CAG/GGN repeat lengths in 557 proven-fertile men. A...
Published in: | Molecular and Cellular Endocrinology |
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Main Authors: | , , , , , , , , , , , , |
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2013
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Online Access: | https://pure.au.dk/portal/da/publications/nonlinear-association-between-androgen-receptor-cag-and-ggn-repeat-lengths-and-reproductive-parameters-in-fertile-european-and-inuit-men(005dbe04-fe43-461d-84cf-1a7ef967255e).html https://doi.org/10.1016/j.mce.2013.03.005 |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/005dbe04-fe43-461d-84cf-1a7ef967255e 2023-05-15T16:55:14+02:00 Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men Brokken, L J S Rylander, L Jönsson, B A Spanò, M Pedersen, H S Ludwicki, J K Zviezdai, V Bizzaro, D Manicardi, G C Toft, Gunnar Bonde, Jens Peter Giwercman, A Lundberg Giwercman, Y 2013-05-06 https://pure.au.dk/portal/da/publications/nonlinear-association-between-androgen-receptor-cag-and-ggn-repeat-lengths-and-reproductive-parameters-in-fertile-european-and-inuit-men(005dbe04-fe43-461d-84cf-1a7ef967255e).html https://doi.org/10.1016/j.mce.2013.03.005 eng eng info:eu-repo/semantics/restrictedAccess Brokken , L J S , Rylander , L , Jönsson , B A , Spanò , M , Pedersen , H S , Ludwicki , J K , Zviezdai , V , Bizzaro , D , Manicardi , G C , Toft , G , Bonde , J P , Giwercman , A & Lundberg Giwercman , Y 2013 , ' Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men ' , Molecular and Cellular Endocrinology , vol. 370 , no. 1-2 , pp. 163-71 . https://doi.org/10.1016/j.mce.2013.03.005 Antigens CD95 Biological Markers Cross-Sectional Studies DNA Fragmentation Estradiol European Continental Ancestry Group Fertility Genetic Association Studies Genitalia Male Genotype Humans Inhibins Inuits Phenotype Prostate-Specific Antigen Receptors Androgen Reproduction Semen Analysis Sperm Count Trinucleotide Repeats alpha-Glucosidases article 2013 ftuniaarhuspubl https://doi.org/10.1016/j.mce.2013.03.005 2020-10-21T22:44:26Z Recently the dogma that there is an inverse linear association between androgen receptor (AR) CAG and GGN polymorphisms and receptor activity has been challenged. We analysed the pattern of association between 21 male reproductive phenotypes and AR CAG/GGN repeat lengths in 557 proven-fertile men. A linear association was only found between sperm DNA fragmentation index (DFI) and CAG length, and between inhibin B and GGN length. Men with longer CAG then the reference (22-24), had higher oestradiol levels, whereas men with shorter CAG stretches had a higher DFI and a higher proportion of Fas-positive germ cells. Subjects with either short or long CAG had increased seminal levels of prostate-specific antigen and neutral α-glucosidase activity. Compared to men with the median GGN length of 23, those with shorter GGN repeats had higher levels of inhibin B, higher proportions of normal and progressive sperm, and a higher fraction of Fas-positive sperm, while men with longer GGN had higher oestradiol levels. These data indicate that at least for some markers of male reproductive function the association with CAG or GGN repeat length is curvilinear. Article in Journal/Newspaper inuit inuits Aarhus University: Research Molecular and Cellular Endocrinology 370 1-2 163 171 |
institution |
Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
Antigens CD95 Biological Markers Cross-Sectional Studies DNA Fragmentation Estradiol European Continental Ancestry Group Fertility Genetic Association Studies Genitalia Male Genotype Humans Inhibins Inuits Phenotype Prostate-Specific Antigen Receptors Androgen Reproduction Semen Analysis Sperm Count Trinucleotide Repeats alpha-Glucosidases |
spellingShingle |
Antigens CD95 Biological Markers Cross-Sectional Studies DNA Fragmentation Estradiol European Continental Ancestry Group Fertility Genetic Association Studies Genitalia Male Genotype Humans Inhibins Inuits Phenotype Prostate-Specific Antigen Receptors Androgen Reproduction Semen Analysis Sperm Count Trinucleotide Repeats alpha-Glucosidases Brokken, L J S Rylander, L Jönsson, B A Spanò, M Pedersen, H S Ludwicki, J K Zviezdai, V Bizzaro, D Manicardi, G C Toft, Gunnar Bonde, Jens Peter Giwercman, A Lundberg Giwercman, Y Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men |
topic_facet |
Antigens CD95 Biological Markers Cross-Sectional Studies DNA Fragmentation Estradiol European Continental Ancestry Group Fertility Genetic Association Studies Genitalia Male Genotype Humans Inhibins Inuits Phenotype Prostate-Specific Antigen Receptors Androgen Reproduction Semen Analysis Sperm Count Trinucleotide Repeats alpha-Glucosidases |
description |
Recently the dogma that there is an inverse linear association between androgen receptor (AR) CAG and GGN polymorphisms and receptor activity has been challenged. We analysed the pattern of association between 21 male reproductive phenotypes and AR CAG/GGN repeat lengths in 557 proven-fertile men. A linear association was only found between sperm DNA fragmentation index (DFI) and CAG length, and between inhibin B and GGN length. Men with longer CAG then the reference (22-24), had higher oestradiol levels, whereas men with shorter CAG stretches had a higher DFI and a higher proportion of Fas-positive germ cells. Subjects with either short or long CAG had increased seminal levels of prostate-specific antigen and neutral α-glucosidase activity. Compared to men with the median GGN length of 23, those with shorter GGN repeats had higher levels of inhibin B, higher proportions of normal and progressive sperm, and a higher fraction of Fas-positive sperm, while men with longer GGN had higher oestradiol levels. These data indicate that at least for some markers of male reproductive function the association with CAG or GGN repeat length is curvilinear. |
format |
Article in Journal/Newspaper |
author |
Brokken, L J S Rylander, L Jönsson, B A Spanò, M Pedersen, H S Ludwicki, J K Zviezdai, V Bizzaro, D Manicardi, G C Toft, Gunnar Bonde, Jens Peter Giwercman, A Lundberg Giwercman, Y |
author_facet |
Brokken, L J S Rylander, L Jönsson, B A Spanò, M Pedersen, H S Ludwicki, J K Zviezdai, V Bizzaro, D Manicardi, G C Toft, Gunnar Bonde, Jens Peter Giwercman, A Lundberg Giwercman, Y |
author_sort |
Brokken, L J S |
title |
Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men |
title_short |
Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men |
title_full |
Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men |
title_fullStr |
Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men |
title_full_unstemmed |
Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men |
title_sort |
non-linear association between androgen receptor cag and ggn repeat lengths and reproductive parameters in fertile european and inuit men |
publishDate |
2013 |
url |
https://pure.au.dk/portal/da/publications/nonlinear-association-between-androgen-receptor-cag-and-ggn-repeat-lengths-and-reproductive-parameters-in-fertile-european-and-inuit-men(005dbe04-fe43-461d-84cf-1a7ef967255e).html https://doi.org/10.1016/j.mce.2013.03.005 |
genre |
inuit inuits |
genre_facet |
inuit inuits |
op_source |
Brokken , L J S , Rylander , L , Jönsson , B A , Spanò , M , Pedersen , H S , Ludwicki , J K , Zviezdai , V , Bizzaro , D , Manicardi , G C , Toft , G , Bonde , J P , Giwercman , A & Lundberg Giwercman , Y 2013 , ' Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men ' , Molecular and Cellular Endocrinology , vol. 370 , no. 1-2 , pp. 163-71 . https://doi.org/10.1016/j.mce.2013.03.005 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.mce.2013.03.005 |
container_title |
Molecular and Cellular Endocrinology |
container_volume |
370 |
container_issue |
1-2 |
container_start_page |
163 |
op_container_end_page |
171 |
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1766046207953600512 |