Antiviral activity of the rhamnolipids mixture from the antarctic bacterium pseudomonas gessardii M15 against herpes simplex viruses and coronaviruses
Emerging and re-emerging viruses represent a serious threat to human health at a global level. In particular, enveloped viruses are one of the main causes of viral outbreaks, as recently demonstrated by SARS-CoV-2. An effective strategy to counteract these viruses could be to target the envelope by...
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Online Access: | http://hdl.handle.net/11591/466874 https://doi.org/10.3390/pharmaceutics13122121 |
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ftuncampaniairis:oai:iris.unicampania.it:11591/466874 2024-04-14T08:04:38+00:00 Antiviral activity of the rhamnolipids mixture from the antarctic bacterium pseudomonas gessardii M15 against herpes simplex viruses and coronaviruses Giugliano R. Buonocore C. Zannella C. Chianese A. Esposito F. P. Tedesco P. De Filippis A. Galdiero M. Franci G. de Pascale D. Giugliano, R. Buonocore, C. Zannella, C. Chianese, A. Esposito, F. P. Tedesco, P. De Filippis, A. Galdiero, M. Franci, G. de Pascale, D. 2021 http://hdl.handle.net/11591/466874 https://doi.org/10.3390/pharmaceutics13122121 eng eng info:eu-repo/semantics/altIdentifier/pmid/34959400 volume:13 issue:12 firstpage:2121 journal:PHARMACEUTICS http://hdl.handle.net/11591/466874 doi:10.3390/pharmaceutics13122121 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85121443395 Antarctic bacteria Antiviral Coron-aviru Enveloped viru Herpe Microbial biosurfactant Rhamnolipid SARS-CoV-2 TEM info:eu-repo/semantics/article 2021 ftuncampaniairis https://doi.org/10.3390/pharmaceutics13122121 2024-03-21T16:25:17Z Emerging and re-emerging viruses represent a serious threat to human health at a global level. In particular, enveloped viruses are one of the main causes of viral outbreaks, as recently demonstrated by SARS-CoV-2. An effective strategy to counteract these viruses could be to target the envelope by using surface-active compounds. Rhamnolipids (RLs) are microbial biosurfactants displaying a wide range of bioactivities, such as antibacterial, antifungal and antibiofilm, among others. Being of microbial origin, they are environmentally-friendly, biodegradable, and less toxic than synthetic surfactants. In this work, we explored the antiviral activity of the rhamnolipids mixture (M15RL) produced by the Antarctic bacteria Pseudomonas gessardii M15 against viruses belonging to Coronaviridae and Herpesviridae families. In addition, we investigated the rhamnolipids’ mode of action and the possibility of inactivating viruses on treated surfaces. Our results show complete inactivation of HSV-1 and HSV-2 by M15RLs at 6μg/mL, and of HCoV-229E and SARSCoV- 2 at 25 and 50μg/mL, respectively. Concerning activity against HCoV-OC43, 80% inhibition of cytopathic effect was recorded, while no activity against naked Poliovirus Type 1 (PV-1) was detectable, suggesting that the antiviral action is mainly directed towards the envelope. In conclusion, we report a significant activity of M15RL against enveloped viruses and demonstrated for the first time the antiviral effect of rhamnolipids against SARS-CoV-2. Article in Journal/Newspaper Antarc* Antarctic Università degli Studi della Campania "Luigi Vanvitelli": CINECA IRIS V: Antarctic The Antarctic Pharmaceutics 13 12 2121 |
institution |
Open Polar |
collection |
Università degli Studi della Campania "Luigi Vanvitelli": CINECA IRIS V: |
op_collection_id |
ftuncampaniairis |
language |
English |
topic |
Antarctic bacteria Antiviral Coron-aviru Enveloped viru Herpe Microbial biosurfactant Rhamnolipid SARS-CoV-2 TEM |
spellingShingle |
Antarctic bacteria Antiviral Coron-aviru Enveloped viru Herpe Microbial biosurfactant Rhamnolipid SARS-CoV-2 TEM Giugliano R. Buonocore C. Zannella C. Chianese A. Esposito F. P. Tedesco P. De Filippis A. Galdiero M. Franci G. de Pascale D. Antiviral activity of the rhamnolipids mixture from the antarctic bacterium pseudomonas gessardii M15 against herpes simplex viruses and coronaviruses |
topic_facet |
Antarctic bacteria Antiviral Coron-aviru Enveloped viru Herpe Microbial biosurfactant Rhamnolipid SARS-CoV-2 TEM |
description |
Emerging and re-emerging viruses represent a serious threat to human health at a global level. In particular, enveloped viruses are one of the main causes of viral outbreaks, as recently demonstrated by SARS-CoV-2. An effective strategy to counteract these viruses could be to target the envelope by using surface-active compounds. Rhamnolipids (RLs) are microbial biosurfactants displaying a wide range of bioactivities, such as antibacterial, antifungal and antibiofilm, among others. Being of microbial origin, they are environmentally-friendly, biodegradable, and less toxic than synthetic surfactants. In this work, we explored the antiviral activity of the rhamnolipids mixture (M15RL) produced by the Antarctic bacteria Pseudomonas gessardii M15 against viruses belonging to Coronaviridae and Herpesviridae families. In addition, we investigated the rhamnolipids’ mode of action and the possibility of inactivating viruses on treated surfaces. Our results show complete inactivation of HSV-1 and HSV-2 by M15RLs at 6μg/mL, and of HCoV-229E and SARSCoV- 2 at 25 and 50μg/mL, respectively. Concerning activity against HCoV-OC43, 80% inhibition of cytopathic effect was recorded, while no activity against naked Poliovirus Type 1 (PV-1) was detectable, suggesting that the antiviral action is mainly directed towards the envelope. In conclusion, we report a significant activity of M15RL against enveloped viruses and demonstrated for the first time the antiviral effect of rhamnolipids against SARS-CoV-2. |
author2 |
Giugliano, R. Buonocore, C. Zannella, C. Chianese, A. Esposito, F. P. Tedesco, P. De Filippis, A. Galdiero, M. Franci, G. de Pascale, D. |
format |
Article in Journal/Newspaper |
author |
Giugliano R. Buonocore C. Zannella C. Chianese A. Esposito F. P. Tedesco P. De Filippis A. Galdiero M. Franci G. de Pascale D. |
author_facet |
Giugliano R. Buonocore C. Zannella C. Chianese A. Esposito F. P. Tedesco P. De Filippis A. Galdiero M. Franci G. de Pascale D. |
author_sort |
Giugliano R. |
title |
Antiviral activity of the rhamnolipids mixture from the antarctic bacterium pseudomonas gessardii M15 against herpes simplex viruses and coronaviruses |
title_short |
Antiviral activity of the rhamnolipids mixture from the antarctic bacterium pseudomonas gessardii M15 against herpes simplex viruses and coronaviruses |
title_full |
Antiviral activity of the rhamnolipids mixture from the antarctic bacterium pseudomonas gessardii M15 against herpes simplex viruses and coronaviruses |
title_fullStr |
Antiviral activity of the rhamnolipids mixture from the antarctic bacterium pseudomonas gessardii M15 against herpes simplex viruses and coronaviruses |
title_full_unstemmed |
Antiviral activity of the rhamnolipids mixture from the antarctic bacterium pseudomonas gessardii M15 against herpes simplex viruses and coronaviruses |
title_sort |
antiviral activity of the rhamnolipids mixture from the antarctic bacterium pseudomonas gessardii m15 against herpes simplex viruses and coronaviruses |
publishDate |
2021 |
url |
http://hdl.handle.net/11591/466874 https://doi.org/10.3390/pharmaceutics13122121 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/34959400 volume:13 issue:12 firstpage:2121 journal:PHARMACEUTICS http://hdl.handle.net/11591/466874 doi:10.3390/pharmaceutics13122121 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85121443395 |
op_doi |
https://doi.org/10.3390/pharmaceutics13122121 |
container_title |
Pharmaceutics |
container_volume |
13 |
container_issue |
12 |
container_start_page |
2121 |
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1796301283347398656 |