Association analyses of novel polymorphisms in the MMP-1 promoter gene with osteoarthritis secondary to hip dysplasia in dogs

• Main Authors: Fassa, V.B., Oertlin, G., Waldhorn, J.G., Álvarez, A.O., Maubecin, E.G., Pazos, D.A., Flores, M., Pinto, G.B., Huguet, M.J., Conte, A., Marrube, G.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. 2010
• Subjects: canis lupus familiaris; displasia de cadera; osteoartritis; gen MMP-1; polimorfismos; hip dysplasia; osteoarthritis; MMP-1 gene; polymorphisms; Argentina; Hallan; Hallo; Indel’; Referencia; Canis lupus
• Online Access: http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_4996; http://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_4996.dir/4996.PDF

Hip dysplasia (HD) is a polygenic disease characterized by joint laxity and lack of congruence leading to osteoarthritis (OA). Under many pathogenic conditions including arthritis, MMP-1 synthesis is augmented. The MMP-1 gene promoter contains cytokine response elements, transcription factors AP-1 a...