THE ROLE OF PLATELET-RICH FIBRIN FACILITATES THE HEALING OF GASTROCNEMIUS MUSCLE DEFECT: A PRELIMINARY STUDY ON ANIMAL MODEL
Background: Scar formation has been a classical issue in the healing of skeletal muscle defect which will results in decrease of strength and function. Platelet-rich plasma (PRP) has been studied to enhance the healing of muscle defect. The disadvantages of it include the risk of immunologic reactio...
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ftunairlanggaojs:oai:e-journal.unair.ac.id:article/9264 2024-09-15T18:33:57+00:00 THE ROLE OF PLATELET-RICH FIBRIN FACILITATES THE HEALING OF GASTROCNEMIUS MUSCLE DEFECT: A PRELIMINARY STUDY ON ANIMAL MODEL Utomo, Dwikora Novembri Hernugrahanto, Kukuh Dwiputra 2019-12-06 application/pdf https://e-journal.unair.ac.id/JOINTS/article/view/9264 eng eng Universitas Airlangga https://e-journal.unair.ac.id/JOINTS/article/view/9264/5210 https://e-journal.unair.ac.id/JOINTS/article/view/9264 Copyright (c) 2018 Journal Orthopaedi and Traumatology Surabaya Journal Orthopaedi and Traumatology Surabaya; Vol. 7 No. 1 (2018): April 2018; 31-41 2460-8742 2722-712X Muscle defect Muscle healing Platelet-rich fibrin info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article 2019 ftunairlanggaojs 2024-07-12T03:46:18Z Background: Scar formation has been a classical issue in the healing of skeletal muscle defect which will results in decrease of strength and function. Platelet-rich plasma (PRP) has been studied to enhance the healing of muscle defect. The disadvantages of it include the risk of immunologic reaction, time-consuming preparation, and lack of scaffold element. Platelet-rich fibrin (PRF) is a new generation of platelet concentrate that provides good source of growth factors and scaffold element necessary for the healing. This study is to provide a fondation of PRF preparation and implantation for the healing of experimental defect of gastrocnemius muscle in an animal model.Purpose: The goal is to provide a fondation of PRF preparation and implantation for the healing of experimental defect of gastrocnemius muscle in an animal model.Methods: Animal Care and Use Committee, Airlangga University approved the study. Twenty New Zealand white rabbits were divided into two groups. In control group, a defect was created in the right gastrocnemius and no implantation was done. In study group, similar defect was created with implantation of PRF. Two and four weeks after surgery, the defect was examined immunohistochemically for the expression of Pax7 protein.Results: The implanted group showed higher IRS score in two and four weeks compared to the control group.Conclusion: The use of PRF facilitates the healing of muscle injury. This study will be used as a fondation for further study on PRF. Article in Journal/Newspaper SCAR Journal of Universitas Airlangga (JOINTS) Journal Orthopaedi and Traumatology Surabaya 7 1 31 |
institution |
Open Polar |
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Journal of Universitas Airlangga |
op_collection_id |
ftunairlanggaojs |
language |
English |
topic |
Muscle defect Muscle healing Platelet-rich fibrin |
spellingShingle |
Muscle defect Muscle healing Platelet-rich fibrin Utomo, Dwikora Novembri Hernugrahanto, Kukuh Dwiputra THE ROLE OF PLATELET-RICH FIBRIN FACILITATES THE HEALING OF GASTROCNEMIUS MUSCLE DEFECT: A PRELIMINARY STUDY ON ANIMAL MODEL |
topic_facet |
Muscle defect Muscle healing Platelet-rich fibrin |
description |
Background: Scar formation has been a classical issue in the healing of skeletal muscle defect which will results in decrease of strength and function. Platelet-rich plasma (PRP) has been studied to enhance the healing of muscle defect. The disadvantages of it include the risk of immunologic reaction, time-consuming preparation, and lack of scaffold element. Platelet-rich fibrin (PRF) is a new generation of platelet concentrate that provides good source of growth factors and scaffold element necessary for the healing. This study is to provide a fondation of PRF preparation and implantation for the healing of experimental defect of gastrocnemius muscle in an animal model.Purpose: The goal is to provide a fondation of PRF preparation and implantation for the healing of experimental defect of gastrocnemius muscle in an animal model.Methods: Animal Care and Use Committee, Airlangga University approved the study. Twenty New Zealand white rabbits were divided into two groups. In control group, a defect was created in the right gastrocnemius and no implantation was done. In study group, similar defect was created with implantation of PRF. Two and four weeks after surgery, the defect was examined immunohistochemically for the expression of Pax7 protein.Results: The implanted group showed higher IRS score in two and four weeks compared to the control group.Conclusion: The use of PRF facilitates the healing of muscle injury. This study will be used as a fondation for further study on PRF. |
format |
Article in Journal/Newspaper |
author |
Utomo, Dwikora Novembri Hernugrahanto, Kukuh Dwiputra |
author_facet |
Utomo, Dwikora Novembri Hernugrahanto, Kukuh Dwiputra |
author_sort |
Utomo, Dwikora Novembri |
title |
THE ROLE OF PLATELET-RICH FIBRIN FACILITATES THE HEALING OF GASTROCNEMIUS MUSCLE DEFECT: A PRELIMINARY STUDY ON ANIMAL MODEL |
title_short |
THE ROLE OF PLATELET-RICH FIBRIN FACILITATES THE HEALING OF GASTROCNEMIUS MUSCLE DEFECT: A PRELIMINARY STUDY ON ANIMAL MODEL |
title_full |
THE ROLE OF PLATELET-RICH FIBRIN FACILITATES THE HEALING OF GASTROCNEMIUS MUSCLE DEFECT: A PRELIMINARY STUDY ON ANIMAL MODEL |
title_fullStr |
THE ROLE OF PLATELET-RICH FIBRIN FACILITATES THE HEALING OF GASTROCNEMIUS MUSCLE DEFECT: A PRELIMINARY STUDY ON ANIMAL MODEL |
title_full_unstemmed |
THE ROLE OF PLATELET-RICH FIBRIN FACILITATES THE HEALING OF GASTROCNEMIUS MUSCLE DEFECT: A PRELIMINARY STUDY ON ANIMAL MODEL |
title_sort |
role of platelet-rich fibrin facilitates the healing of gastrocnemius muscle defect: a preliminary study on animal model |
publisher |
Universitas Airlangga |
publishDate |
2019 |
url |
https://e-journal.unair.ac.id/JOINTS/article/view/9264 |
genre |
SCAR |
genre_facet |
SCAR |
op_source |
Journal Orthopaedi and Traumatology Surabaya; Vol. 7 No. 1 (2018): April 2018; 31-41 2460-8742 2722-712X |
op_relation |
https://e-journal.unair.ac.id/JOINTS/article/view/9264/5210 https://e-journal.unair.ac.id/JOINTS/article/view/9264 |
op_rights |
Copyright (c) 2018 Journal Orthopaedi and Traumatology Surabaya |
container_title |
(JOINTS) Journal Orthopaedi and Traumatology Surabaya |
container_volume |
7 |
container_issue |
1 |
container_start_page |
31 |
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1810475682663235584 |