Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust
Highlights: 1. This study identified feasible and affordable alternatives to ineffective conventional cement production pollution control strategies.2.M. oleifera, H. sabdariffa, T. occidentalis, and Z. officinale are effective as personal interventions to ameliorate the effects of cement pollution....
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ftunairlanggaojs:oai:e-journal.unair.ac.id:article/42346 2023-10-01T03:59:07+02:00 Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust Yahaya, Tajudeen Olanrewaju Salisu, Titilola Musa, Mohammed Abdulrazaq Izuafa Chidiebere Obi Samuel Ribah Suleiman Abubakar 2023-06-10 application/pdf https://e-journal.unair.ac.id/FMI/article/view/42346 eng eng Universitas Airlangga https://e-journal.unair.ac.id/FMI/article/view/42346/26103 https://e-journal.unair.ac.id/FMI/article/view/42346 Copyright (c) 2023 Folia Medica Indonesiana http://creativecommons.org/licenses/by-nc-sa/4.0 Folia Medica Indonesiana; Vol. 59 No. 2 (2023): June; 99-107 2599-056X 2355-8393 Cement dust Congested alveoli DNA purity Pollution Zingiber officinale info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article 2023 ftunairlanggaojs 2023-09-05T19:08:31Z Highlights: 1. This study identified feasible and affordable alternatives to ineffective conventional cement production pollution control strategies.2.M. oleifera, H. sabdariffa, T. occidentalis, and Z. officinale are effective as personal interventions to ameliorate the effects of cement pollution. Abstract Conventional pollution control strategies in the cement industry have proven ineffective. As a result, effective and targeted complementary interventions are necessary. This study used roof rats (Rattus rattus) inhabiting the premises of a cement plant in Sagamu, Ogun State, Nigeria, to evaluate the ameliorative effects of moringa (Moringa oleifera), roselle (Hibiscus sabdariffa), fluted pumpkin (Telfairia occidentalis), and ginger (Zingiber officinale) on cement dust exposure. A total of 42 rats were divided into seven groups, with each group consisting of six rats. Group 1 served as the negative control group and was not exposed to any substances, while group 2 served as the positive control group and received standard feed throughout the experiment. Meanwhile, groups 3, 4, 5, 6, and 7 served as the experimental group. Rats in these groups were fed with 400 mg/kg of ethanolic extracts of Z. officinale, M. oleifera, T. occidentalis, H. sabdariffa, and a mixture of the four extracts with a composition of 1:1:1:1, respectively, for 90 days. The plasma DNA concentrations, DNA purity, and lungs of the rats were examined before and after the experiment. Prior to the experiment, the exposed rats had higher plasma DNA concentrations and lower DNA purity, as well as severe fibrosis and congested alveoli in their lungs, compared to the unexposed rats. At the end of the experiment, the experimental groups showed a significant increase in DNA purity (p≤0.05) and a decline in plasma DNA concentrations compared to the positive control group. In addition, the experimental groups showed fewer histopathological abnormalities than the positive control group. The mixture of the extracts yielded the most favorable results, ... Article in Journal/Newspaper Rattus rattus Journal of Universitas Airlangga |
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Open Polar |
collection |
Journal of Universitas Airlangga |
op_collection_id |
ftunairlanggaojs |
language |
English |
topic |
Cement dust Congested alveoli DNA purity Pollution Zingiber officinale |
spellingShingle |
Cement dust Congested alveoli DNA purity Pollution Zingiber officinale Yahaya, Tajudeen Olanrewaju Salisu, Titilola Musa, Mohammed Abdulrazaq Izuafa Chidiebere Obi Samuel Ribah Suleiman Abubakar Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust |
topic_facet |
Cement dust Congested alveoli DNA purity Pollution Zingiber officinale |
description |
Highlights: 1. This study identified feasible and affordable alternatives to ineffective conventional cement production pollution control strategies.2.M. oleifera, H. sabdariffa, T. occidentalis, and Z. officinale are effective as personal interventions to ameliorate the effects of cement pollution. Abstract Conventional pollution control strategies in the cement industry have proven ineffective. As a result, effective and targeted complementary interventions are necessary. This study used roof rats (Rattus rattus) inhabiting the premises of a cement plant in Sagamu, Ogun State, Nigeria, to evaluate the ameliorative effects of moringa (Moringa oleifera), roselle (Hibiscus sabdariffa), fluted pumpkin (Telfairia occidentalis), and ginger (Zingiber officinale) on cement dust exposure. A total of 42 rats were divided into seven groups, with each group consisting of six rats. Group 1 served as the negative control group and was not exposed to any substances, while group 2 served as the positive control group and received standard feed throughout the experiment. Meanwhile, groups 3, 4, 5, 6, and 7 served as the experimental group. Rats in these groups were fed with 400 mg/kg of ethanolic extracts of Z. officinale, M. oleifera, T. occidentalis, H. sabdariffa, and a mixture of the four extracts with a composition of 1:1:1:1, respectively, for 90 days. The plasma DNA concentrations, DNA purity, and lungs of the rats were examined before and after the experiment. Prior to the experiment, the exposed rats had higher plasma DNA concentrations and lower DNA purity, as well as severe fibrosis and congested alveoli in their lungs, compared to the unexposed rats. At the end of the experiment, the experimental groups showed a significant increase in DNA purity (p≤0.05) and a decline in plasma DNA concentrations compared to the positive control group. In addition, the experimental groups showed fewer histopathological abnormalities than the positive control group. The mixture of the extracts yielded the most favorable results, ... |
format |
Article in Journal/Newspaper |
author |
Yahaya, Tajudeen Olanrewaju Salisu, Titilola Musa, Mohammed Abdulrazaq Izuafa Chidiebere Obi Samuel Ribah Suleiman Abubakar |
author_facet |
Yahaya, Tajudeen Olanrewaju Salisu, Titilola Musa, Mohammed Abdulrazaq Izuafa Chidiebere Obi Samuel Ribah Suleiman Abubakar |
author_sort |
Yahaya, Tajudeen Olanrewaju |
title |
Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust |
title_short |
Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust |
title_full |
Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust |
title_fullStr |
Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust |
title_full_unstemmed |
Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust |
title_sort |
selected vegetables and spices improve dna quality and histopathological abnormalities in roof rats (rattus rattus) exposed to cement dust |
publisher |
Universitas Airlangga |
publishDate |
2023 |
url |
https://e-journal.unair.ac.id/FMI/article/view/42346 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Folia Medica Indonesiana; Vol. 59 No. 2 (2023): June; 99-107 2599-056X 2355-8393 |
op_relation |
https://e-journal.unair.ac.id/FMI/article/view/42346/26103 https://e-journal.unair.ac.id/FMI/article/view/42346 |
op_rights |
Copyright (c) 2023 Folia Medica Indonesiana http://creativecommons.org/licenses/by-nc-sa/4.0 |
_version_ |
1778532664049926144 |