Skeletal and hormonal responses to vitamin D supplementation during sunlight deprivation in Antarctic expeditioners
UNLABELLED: Sunlight deprivation results in vitamin D deficiency but serum vitamin D levels can be maintained above 50 nmol/L when supplemented with 50,000 IU at least every alternate month. INTRODUCTION: Antarctic expeditioners are exposed to prolonged sunlight deprivation resulting in vitamin D de...
Published in: | Osteoporosis International |
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Language: | English |
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SPRINGER LONDON LTD
2012
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Online Access: | http://hdl.handle.net/11343/122048 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308818300006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c https://doi.org/10.1007/s00198-011-1858-9 |
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ftumelbourne:oai:jupiter.its.unimelb.edu.au:11343/122048 2023-05-15T13:55:52+02:00 Skeletal and hormonal responses to vitamin D supplementation during sunlight deprivation in Antarctic expeditioners Iuliano-Burns, S Ayton, J Hillam, S Jones, G King, K Macleod, S Seeman, E 2012-10-01 http://hdl.handle.net/11343/122048 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308818300006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c https://doi.org/10.1007/s00198-011-1858-9 English eng SPRINGER LONDON LTD doi:10.1007/s00198-011-1858-9 issn:0937-941X http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308818300006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c Iuliano-Burns, S; Ayton, J; Hillam, S; Jones, G; King, K; Macleod, S; Seeman, E, Skeletal and hormonal responses to vitamin D supplementation during sunlight deprivation in Antarctic expeditioners, OSTEOPOROSIS INTERNATIONAL, 2012, 23 (10), pp. 2461 - 2467 0937-941X http://hdl.handle.net/11343/122048 Journal Article 2012 ftumelbourne https://doi.org/10.1007/s00198-011-1858-9 2019-10-15T12:18:12Z UNLABELLED: Sunlight deprivation results in vitamin D deficiency but serum vitamin D levels can be maintained above 50 nmol/L when supplemented with 50,000 IU at least every alternate month. INTRODUCTION: Antarctic expeditioners are exposed to prolonged sunlight deprivation resulting in vitamin D deficiency. We hypothesised that monthly dosing of 50,000 IU vitamin D (~1,600 IU daily) will increase serum 25-hydroxyvitamin D (25(OH)D), suppress parathyroid hormone (PTH) and improve bone mineral density (BMD), 50,000 IU alternate months (~800 IU daily) will maintain these measures, while a single 50,000 IU dose pre-departure (~1,00 IU daily) will not be protective. METHODS: This was a randomised double-blind study involving 110 healthy adults: 91 males, mean age 41 years (range 24-65 years) working in Antarctica for up to 12 months, who we administered 50,000 IU vitamin D3 monthly, alternate months or a single dose pre-departure. Serum 25(OH)D, PTH, osteocalcin, CTx and calcium were assessed at baseline, mid- and end of expedition. Proximal femur and lumbar spine BMD were assessed pre- and post-expedition. RESULTS: Baseline 25(OH)D was 59 ± 14 nmol/L. By mid-expedition, 25(OH)D increased by 7 nmol/L in those supplemented monthly (p < 0.05) and remained unchanged in those supplemented in alternate months. In those given a single dose pre-departure, 25(OH)D decreased by 8 nmol/L (p < 0.05) and PTH increased by 27% (p < 0.09). Serum osteocalcin increased by ~22% in all groups but BMD remained unchanged. If serum 25(OH)D was >50 nmol/L at baseline, 25(OH)D was maintained above this level with all regimens. If 25(OH)D was <50 nmol/L at baseline, monthly or alternate month regimens were needed to achieve levels >50 nmol/L, the single pre-departure dose was ineffective. CONCLUSION: During sunlight deprivation of up to 12 months, serum 25(OH)D levels can be maintained above 50 nmol/L when expeditioners are provided with 50,000 I U at least every alternate month. Article in Journal/Newspaper Antarc* Antarctic Antarctica The University of Melbourne: Digital Repository Antarctic Osteoporosis International 23 10 2461 2467 |
institution |
Open Polar |
collection |
The University of Melbourne: Digital Repository |
op_collection_id |
ftumelbourne |
language |
English |
description |
UNLABELLED: Sunlight deprivation results in vitamin D deficiency but serum vitamin D levels can be maintained above 50 nmol/L when supplemented with 50,000 IU at least every alternate month. INTRODUCTION: Antarctic expeditioners are exposed to prolonged sunlight deprivation resulting in vitamin D deficiency. We hypothesised that monthly dosing of 50,000 IU vitamin D (~1,600 IU daily) will increase serum 25-hydroxyvitamin D (25(OH)D), suppress parathyroid hormone (PTH) and improve bone mineral density (BMD), 50,000 IU alternate months (~800 IU daily) will maintain these measures, while a single 50,000 IU dose pre-departure (~1,00 IU daily) will not be protective. METHODS: This was a randomised double-blind study involving 110 healthy adults: 91 males, mean age 41 years (range 24-65 years) working in Antarctica for up to 12 months, who we administered 50,000 IU vitamin D3 monthly, alternate months or a single dose pre-departure. Serum 25(OH)D, PTH, osteocalcin, CTx and calcium were assessed at baseline, mid- and end of expedition. Proximal femur and lumbar spine BMD were assessed pre- and post-expedition. RESULTS: Baseline 25(OH)D was 59 ± 14 nmol/L. By mid-expedition, 25(OH)D increased by 7 nmol/L in those supplemented monthly (p < 0.05) and remained unchanged in those supplemented in alternate months. In those given a single dose pre-departure, 25(OH)D decreased by 8 nmol/L (p < 0.05) and PTH increased by 27% (p < 0.09). Serum osteocalcin increased by ~22% in all groups but BMD remained unchanged. If serum 25(OH)D was >50 nmol/L at baseline, 25(OH)D was maintained above this level with all regimens. If 25(OH)D was <50 nmol/L at baseline, monthly or alternate month regimens were needed to achieve levels >50 nmol/L, the single pre-departure dose was ineffective. CONCLUSION: During sunlight deprivation of up to 12 months, serum 25(OH)D levels can be maintained above 50 nmol/L when expeditioners are provided with 50,000 I U at least every alternate month. |
format |
Article in Journal/Newspaper |
author |
Iuliano-Burns, S Ayton, J Hillam, S Jones, G King, K Macleod, S Seeman, E |
spellingShingle |
Iuliano-Burns, S Ayton, J Hillam, S Jones, G King, K Macleod, S Seeman, E Skeletal and hormonal responses to vitamin D supplementation during sunlight deprivation in Antarctic expeditioners |
author_facet |
Iuliano-Burns, S Ayton, J Hillam, S Jones, G King, K Macleod, S Seeman, E |
author_sort |
Iuliano-Burns, S |
title |
Skeletal and hormonal responses to vitamin D supplementation during sunlight deprivation in Antarctic expeditioners |
title_short |
Skeletal and hormonal responses to vitamin D supplementation during sunlight deprivation in Antarctic expeditioners |
title_full |
Skeletal and hormonal responses to vitamin D supplementation during sunlight deprivation in Antarctic expeditioners |
title_fullStr |
Skeletal and hormonal responses to vitamin D supplementation during sunlight deprivation in Antarctic expeditioners |
title_full_unstemmed |
Skeletal and hormonal responses to vitamin D supplementation during sunlight deprivation in Antarctic expeditioners |
title_sort |
skeletal and hormonal responses to vitamin d supplementation during sunlight deprivation in antarctic expeditioners |
publisher |
SPRINGER LONDON LTD |
publishDate |
2012 |
url |
http://hdl.handle.net/11343/122048 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308818300006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c https://doi.org/10.1007/s00198-011-1858-9 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_relation |
doi:10.1007/s00198-011-1858-9 issn:0937-941X http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308818300006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c Iuliano-Burns, S; Ayton, J; Hillam, S; Jones, G; King, K; Macleod, S; Seeman, E, Skeletal and hormonal responses to vitamin D supplementation during sunlight deprivation in Antarctic expeditioners, OSTEOPOROSIS INTERNATIONAL, 2012, 23 (10), pp. 2461 - 2467 0937-941X http://hdl.handle.net/11343/122048 |
op_doi |
https://doi.org/10.1007/s00198-011-1858-9 |
container_title |
Osteoporosis International |
container_volume |
23 |
container_issue |
10 |
container_start_page |
2461 |
op_container_end_page |
2467 |
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1766262779803598848 |