A Clinical and Genetic Study of Psoriatic Arthritis
Psoriatic arthritis (PsA) is an inflammatory joint disease associated with psoriasis. PsA has a heterogeneous pattern, expressed by different manifestations such as mild mono-oligoarthritis or very severe, erosive and destructive polyarthritis. Measurable inflammatory activity is not always prominen...
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Reumatologi
2003
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ftumeauniv:oai:DiVA.org:umu-78 2023-10-09T21:54:37+02:00 A Clinical and Genetic Study of Psoriatic Arthritis Alenius, Gerd-Marie 2003 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-78 eng eng Reumatologi Umeå : Folkhälsa och klinisk medicin Umeå University medical dissertations, 0346-6612 829 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-78 urn:isbn:91-7305-398-8 info:eu-repo/semantics/openAccess Public health Psoriatic arthritis prevalence inflammatory manifestations genetic loci HLA TNFB Folkhälsomedicin Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Doctoral thesis, comprehensive summary info:eu-repo/semantics/doctoralThesis text 2003 ftumeauniv 2023-09-22T13:47:21Z Psoriatic arthritis (PsA) is an inflammatory joint disease associated with psoriasis. PsA has a heterogeneous pattern, expressed by different manifestations such as mild mono-oligoarthritis or very severe, erosive and destructive polyarthritis. Measurable inflammatory activity is not always prominent. The aetiology is unknown but genetic factors are believed to be of importance. The pattern of inheritance is proposed to be polygenic. The aim of this study was to estimate the prevalence of joint and axial manifestations, characterise the disease in relation to inflammatory and genetic markers, and to identify disease susceptibility gene(s) for PsA in patients from northern Sweden. All patients from the city of Umeå (n=276), selected from a community and hospital based psoriasis register (n=1737) at the Dept of Dermatology, were invited to a prevalence study. Two hundred-two patients were examined and 97 (48%) had inflammatory manifestations such as peripheral arthritis, axial disease, undifferentiated spondylarthropathy (uSpA) and enthesopathies. Of the 67 patients (33 %) with peripheral arthritis and/or axial disease, 30 were not previously diagnosed. The association of clinical manifestations and potential markers of aggressive joint disease with HLA associations were analysed in 88 patients with PsA. We were not able to confirm findings of other groups reporting strong association with several HLA-antigens. The prevalence of HLA-B17, B37 and B62 was increased compared with controls, but the strongest predictive factors among our patients for an aggressive disease, in a multiple logistic analysis, were polyarthritic disease and distal interphalangeal engagement. In order to investigate for disease susceptibility genes, five genetic loci were analysed with microsatellites and single nucleotide polymorphisms in an association study of 120 patients with PsA. There was a significant association with the TNFB locus on chromosome 6p but not with any other loci examined; 1q21 (PSORS4), 3q21 (PSORS5), 8q24 and CTLA4. ... Doctoral or Postdoctoral Thesis Northern Sweden Umeå University: Publications (DiVA) |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Public health Psoriatic arthritis prevalence inflammatory manifestations genetic loci HLA TNFB Folkhälsomedicin Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
spellingShingle |
Public health Psoriatic arthritis prevalence inflammatory manifestations genetic loci HLA TNFB Folkhälsomedicin Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Alenius, Gerd-Marie A Clinical and Genetic Study of Psoriatic Arthritis |
topic_facet |
Public health Psoriatic arthritis prevalence inflammatory manifestations genetic loci HLA TNFB Folkhälsomedicin Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
description |
Psoriatic arthritis (PsA) is an inflammatory joint disease associated with psoriasis. PsA has a heterogeneous pattern, expressed by different manifestations such as mild mono-oligoarthritis or very severe, erosive and destructive polyarthritis. Measurable inflammatory activity is not always prominent. The aetiology is unknown but genetic factors are believed to be of importance. The pattern of inheritance is proposed to be polygenic. The aim of this study was to estimate the prevalence of joint and axial manifestations, characterise the disease in relation to inflammatory and genetic markers, and to identify disease susceptibility gene(s) for PsA in patients from northern Sweden. All patients from the city of Umeå (n=276), selected from a community and hospital based psoriasis register (n=1737) at the Dept of Dermatology, were invited to a prevalence study. Two hundred-two patients were examined and 97 (48%) had inflammatory manifestations such as peripheral arthritis, axial disease, undifferentiated spondylarthropathy (uSpA) and enthesopathies. Of the 67 patients (33 %) with peripheral arthritis and/or axial disease, 30 were not previously diagnosed. The association of clinical manifestations and potential markers of aggressive joint disease with HLA associations were analysed in 88 patients with PsA. We were not able to confirm findings of other groups reporting strong association with several HLA-antigens. The prevalence of HLA-B17, B37 and B62 was increased compared with controls, but the strongest predictive factors among our patients for an aggressive disease, in a multiple logistic analysis, were polyarthritic disease and distal interphalangeal engagement. In order to investigate for disease susceptibility genes, five genetic loci were analysed with microsatellites and single nucleotide polymorphisms in an association study of 120 patients with PsA. There was a significant association with the TNFB locus on chromosome 6p but not with any other loci examined; 1q21 (PSORS4), 3q21 (PSORS5), 8q24 and CTLA4. ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Alenius, Gerd-Marie |
author_facet |
Alenius, Gerd-Marie |
author_sort |
Alenius, Gerd-Marie |
title |
A Clinical and Genetic Study of Psoriatic Arthritis |
title_short |
A Clinical and Genetic Study of Psoriatic Arthritis |
title_full |
A Clinical and Genetic Study of Psoriatic Arthritis |
title_fullStr |
A Clinical and Genetic Study of Psoriatic Arthritis |
title_full_unstemmed |
A Clinical and Genetic Study of Psoriatic Arthritis |
title_sort |
clinical and genetic study of psoriatic arthritis |
publisher |
Reumatologi |
publishDate |
2003 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-78 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Umeå University medical dissertations, 0346-6612 829 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-78 urn:isbn:91-7305-398-8 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1779318269979656192 |