Circulating levels of 25-hydroxyvitamin D and risk of breast cancer : a nested case-control study
Introduction: Experimental evidence suggests a protective role for circulating 25-hydroxyvitamin D (25(OH) D) in breast cancer development, but the results of epidemiological studies have been inconsistent. Methods: We conducted a case-control study nested within two prospective cohorts, the New Yor...
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Umeå universitet, Onkologi
2013
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ftumeauniv:oai:DiVA.org:umu-76821 2023-10-09T21:54:36+02:00 Circulating levels of 25-hydroxyvitamin D and risk of breast cancer : a nested case-control study Scarmo, Stephanie Afanasyeva, Yelena Lenner, Per Koenig, Karen L Horst, Ronald L Clendenen, Tess V Arslan, Alan A Chen, Yu Hallmans, Göran Lundin, Eva Rinaldi, Sabina Toniolo, Paolo Shore, Roy E Zeleniuch-Jacquotte, Anne 2013 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-76821 https://doi.org/10.1186/bcr3390 eng eng Umeå universitet, Onkologi Umeå universitet, Näringsforskning Umeå universitet, Enheten för biobanksforskning Breast Cancer Research, 1465-5411, 2013, 15:1, s. R15- orcid:0000-0001-9581-3845 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-76821 doi:10.1186/bcr3390 ISI:000320158100024 Scopus 2-s2.0-84874199657 info:eu-repo/semantics/openAccess Cancer and Oncology Cancer och onkologi Article in journal info:eu-repo/semantics/article text 2013 ftumeauniv https://doi.org/10.1186/bcr3390 2023-09-22T13:57:41Z Introduction: Experimental evidence suggests a protective role for circulating 25-hydroxyvitamin D (25(OH) D) in breast cancer development, but the results of epidemiological studies have been inconsistent. Methods: We conducted a case-control study nested within two prospective cohorts, the New York University Women's Health Study and the Northern Sweden Mammary Screening Cohort. Blood samples were collected at enrollment, and women were followed up for breast cancer ascertainment. In total, 1,585 incident breast cancer cases were individually-matched to 2,940 controls. Of these subjects, 678 cases and 1,208 controls contributed two repeat blood samples, at least one year apart. Circulating levels of 25(OH) D were measured, and multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Results: No association was observed between circulating levels of 25(OH) D and overall breast cancer risk (multivariate-adjusted model OR = 0.94, 95% CI = 0.76-1.16 for the highest vs. lowest quintile, ptrend = 0.30). The temporal reliability of 25(OH)D measured in repeat blood samples was high (intraclass correlation coefficients for season-adjusted 25(OH) D > 0.70). An inverse association between 25(OH) D levels and breast cancer risk was observed among women who were = 45 years of age (ORQ5-Q1 = 0.48, 95% CI = 0.30-0.79, ptrend = 0.01) or premenopausal at enrollment (ORQ5-Q1 = 0.67, 95% CI = 0.48-0.92, ptrend = 0.03). Conclusions: Circulating 25(OH) D levels were not associated with breast cancer risk overall, although we could not exclude the possibility of a protective effect in younger women. Recommendations regarding vitamin D supplementation should be based on considerations other than breast cancer prevention. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Breast Cancer Research 15 1 |
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collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Cancer and Oncology Cancer och onkologi |
spellingShingle |
Cancer and Oncology Cancer och onkologi Scarmo, Stephanie Afanasyeva, Yelena Lenner, Per Koenig, Karen L Horst, Ronald L Clendenen, Tess V Arslan, Alan A Chen, Yu Hallmans, Göran Lundin, Eva Rinaldi, Sabina Toniolo, Paolo Shore, Roy E Zeleniuch-Jacquotte, Anne Circulating levels of 25-hydroxyvitamin D and risk of breast cancer : a nested case-control study |
topic_facet |
Cancer and Oncology Cancer och onkologi |
description |
Introduction: Experimental evidence suggests a protective role for circulating 25-hydroxyvitamin D (25(OH) D) in breast cancer development, but the results of epidemiological studies have been inconsistent. Methods: We conducted a case-control study nested within two prospective cohorts, the New York University Women's Health Study and the Northern Sweden Mammary Screening Cohort. Blood samples were collected at enrollment, and women were followed up for breast cancer ascertainment. In total, 1,585 incident breast cancer cases were individually-matched to 2,940 controls. Of these subjects, 678 cases and 1,208 controls contributed two repeat blood samples, at least one year apart. Circulating levels of 25(OH) D were measured, and multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Results: No association was observed between circulating levels of 25(OH) D and overall breast cancer risk (multivariate-adjusted model OR = 0.94, 95% CI = 0.76-1.16 for the highest vs. lowest quintile, ptrend = 0.30). The temporal reliability of 25(OH)D measured in repeat blood samples was high (intraclass correlation coefficients for season-adjusted 25(OH) D > 0.70). An inverse association between 25(OH) D levels and breast cancer risk was observed among women who were = 45 years of age (ORQ5-Q1 = 0.48, 95% CI = 0.30-0.79, ptrend = 0.01) or premenopausal at enrollment (ORQ5-Q1 = 0.67, 95% CI = 0.48-0.92, ptrend = 0.03). Conclusions: Circulating 25(OH) D levels were not associated with breast cancer risk overall, although we could not exclude the possibility of a protective effect in younger women. Recommendations regarding vitamin D supplementation should be based on considerations other than breast cancer prevention. |
format |
Article in Journal/Newspaper |
author |
Scarmo, Stephanie Afanasyeva, Yelena Lenner, Per Koenig, Karen L Horst, Ronald L Clendenen, Tess V Arslan, Alan A Chen, Yu Hallmans, Göran Lundin, Eva Rinaldi, Sabina Toniolo, Paolo Shore, Roy E Zeleniuch-Jacquotte, Anne |
author_facet |
Scarmo, Stephanie Afanasyeva, Yelena Lenner, Per Koenig, Karen L Horst, Ronald L Clendenen, Tess V Arslan, Alan A Chen, Yu Hallmans, Göran Lundin, Eva Rinaldi, Sabina Toniolo, Paolo Shore, Roy E Zeleniuch-Jacquotte, Anne |
author_sort |
Scarmo, Stephanie |
title |
Circulating levels of 25-hydroxyvitamin D and risk of breast cancer : a nested case-control study |
title_short |
Circulating levels of 25-hydroxyvitamin D and risk of breast cancer : a nested case-control study |
title_full |
Circulating levels of 25-hydroxyvitamin D and risk of breast cancer : a nested case-control study |
title_fullStr |
Circulating levels of 25-hydroxyvitamin D and risk of breast cancer : a nested case-control study |
title_full_unstemmed |
Circulating levels of 25-hydroxyvitamin D and risk of breast cancer : a nested case-control study |
title_sort |
circulating levels of 25-hydroxyvitamin d and risk of breast cancer : a nested case-control study |
publisher |
Umeå universitet, Onkologi |
publishDate |
2013 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-76821 https://doi.org/10.1186/bcr3390 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Breast Cancer Research, 1465-5411, 2013, 15:1, s. R15- orcid:0000-0001-9581-3845 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-76821 doi:10.1186/bcr3390 ISI:000320158100024 Scopus 2-s2.0-84874199657 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/bcr3390 |
container_title |
Breast Cancer Research |
container_volume |
15 |
container_issue |
1 |
_version_ |
1779318230123282432 |