Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction : a case-control study
BACKGROUND: The n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid, which are present in fish, are protective against myocardial infarction. However, fish also contains methylmercury, which influences the risk of myocardial infarction, possibly by generating oxidative str...
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Umeå universitet, Yrkes- och miljömedicin
2011
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49645 https://doi.org/10.1186/1476-069X-10-33 |
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ftumeauniv:oai:DiVA.org:umu-49645 2023-10-09T21:54:37+02:00 Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction : a case-control study Engström, Karin S Wennberg, Maria Strömberg, Ulf Bergdahl, Ingvar A. Hallmans, Göran Jansson, Jan-Håkan Lundh, Thomas Norberg, Margareta Rentschler, Gerda Vessby, Bengt Skerfving, Staffan Broberg, Karin 2011 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49645 https://doi.org/10.1186/1476-069X-10-33 eng eng Umeå universitet, Yrkes- och miljömedicin Umeå universitet, Näringsforskning Umeå universitet, Medicin Umeå universitet, Epidemiologi och global hälsa Department of Medicine, Skellefteå Hospital, Skellefteå, Sweden Environmental Health, 2011, 10, s. Article nr 33- orcid:0000-0001-9581-3845 orcid:0000-0003-2475-7131 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49645 doi:10.1186/1476-069X-10-33 PMID 21504558 ISI:000291161800001 Scopus 2-s2.0-79955123363 info:eu-repo/semantics/openAccess Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Occupational Health and Environmental Health Arbetsmedicin och miljömedicin Article in journal info:eu-repo/semantics/article text 2011 ftumeauniv https://doi.org/10.1186/1476-069X-10-33 2023-09-22T13:59:40Z BACKGROUND: The n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid, which are present in fish, are protective against myocardial infarction. However, fish also contains methylmercury, which influences the risk of myocardial infarction, possibly by generating oxidative stress. Methylmercury is metabolized by conjugation to glutathione, which facilitates elimination. Glutathione is also an antioxidant. Individuals with certain polymorphisms in glutathione-related genes may tolerate higher exposures to methylmercury, due to faster metabolism and elimination and/or better glutathione-associated antioxidative capacity. They would thus benefit more from the protective agents in fish, such as eicosapentaenoic+docosahexaenoic acid and selenium. The objective for this study was to elucidate whether genetic polymorphisms in glutathione-related genes modify the association between eicosapentaenoic+docosahexaenoic acid or methylmercury and risk of first ever myocardial infarction. METHODS: Polymorphisms in glutathione-synthesizing (glutamyl-cysteine ligase catalytic subunit, GCLC and glutamyl-cysteine ligase modifier subunit, GCLM) or glutathione-conjugating (glutathione S-transferase P, GSTP1) genes were genotyped in 1027 individuals from northern Sweden (458 cases of first-ever myocardial infarction and 569 matched controls). The impact of these polymorphisms on the association between erythrocyte-mercury (proxy for methylmercury) and risk of myocardial infarction, as well as between plasma eicosapentaenoic+docosahexaenoic acid and risk of myocardial infarction, was evaluated by conditional logistic regression. The effect of erythrocyte-selenium on risk of myocardial infarction was also taken into consideration. RESULTS: There were no strong genetic modifying effects on the association between plasma eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury and risk of myocardial infarction risk. When eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury were divided into tertiles, ... Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Environmental Health 10 1 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Occupational Health and Environmental Health Arbetsmedicin och miljömedicin |
spellingShingle |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Occupational Health and Environmental Health Arbetsmedicin och miljömedicin Engström, Karin S Wennberg, Maria Strömberg, Ulf Bergdahl, Ingvar A. Hallmans, Göran Jansson, Jan-Håkan Lundh, Thomas Norberg, Margareta Rentschler, Gerda Vessby, Bengt Skerfving, Staffan Broberg, Karin Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction : a case-control study |
topic_facet |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Occupational Health and Environmental Health Arbetsmedicin och miljömedicin |
description |
BACKGROUND: The n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid, which are present in fish, are protective against myocardial infarction. However, fish also contains methylmercury, which influences the risk of myocardial infarction, possibly by generating oxidative stress. Methylmercury is metabolized by conjugation to glutathione, which facilitates elimination. Glutathione is also an antioxidant. Individuals with certain polymorphisms in glutathione-related genes may tolerate higher exposures to methylmercury, due to faster metabolism and elimination and/or better glutathione-associated antioxidative capacity. They would thus benefit more from the protective agents in fish, such as eicosapentaenoic+docosahexaenoic acid and selenium. The objective for this study was to elucidate whether genetic polymorphisms in glutathione-related genes modify the association between eicosapentaenoic+docosahexaenoic acid or methylmercury and risk of first ever myocardial infarction. METHODS: Polymorphisms in glutathione-synthesizing (glutamyl-cysteine ligase catalytic subunit, GCLC and glutamyl-cysteine ligase modifier subunit, GCLM) or glutathione-conjugating (glutathione S-transferase P, GSTP1) genes were genotyped in 1027 individuals from northern Sweden (458 cases of first-ever myocardial infarction and 569 matched controls). The impact of these polymorphisms on the association between erythrocyte-mercury (proxy for methylmercury) and risk of myocardial infarction, as well as between plasma eicosapentaenoic+docosahexaenoic acid and risk of myocardial infarction, was evaluated by conditional logistic regression. The effect of erythrocyte-selenium on risk of myocardial infarction was also taken into consideration. RESULTS: There were no strong genetic modifying effects on the association between plasma eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury and risk of myocardial infarction risk. When eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury were divided into tertiles, ... |
format |
Article in Journal/Newspaper |
author |
Engström, Karin S Wennberg, Maria Strömberg, Ulf Bergdahl, Ingvar A. Hallmans, Göran Jansson, Jan-Håkan Lundh, Thomas Norberg, Margareta Rentschler, Gerda Vessby, Bengt Skerfving, Staffan Broberg, Karin |
author_facet |
Engström, Karin S Wennberg, Maria Strömberg, Ulf Bergdahl, Ingvar A. Hallmans, Göran Jansson, Jan-Håkan Lundh, Thomas Norberg, Margareta Rentschler, Gerda Vessby, Bengt Skerfving, Staffan Broberg, Karin |
author_sort |
Engström, Karin S |
title |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction : a case-control study |
title_short |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction : a case-control study |
title_full |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction : a case-control study |
title_fullStr |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction : a case-control study |
title_full_unstemmed |
Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction : a case-control study |
title_sort |
evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction : a case-control study |
publisher |
Umeå universitet, Yrkes- och miljömedicin |
publishDate |
2011 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49645 https://doi.org/10.1186/1476-069X-10-33 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Environmental Health, 2011, 10, s. Article nr 33- orcid:0000-0001-9581-3845 orcid:0000-0003-2475-7131 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49645 doi:10.1186/1476-069X-10-33 PMID 21504558 ISI:000291161800001 Scopus 2-s2.0-79955123363 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/1476-069X-10-33 |
container_title |
Environmental Health |
container_volume |
10 |
container_issue |
1 |
_version_ |
1779318282553131008 |