Metabolic profiles associated with exposure to ambient particulate air pollution : findings from the Betula cohort
Introduction: Air pollution is a significant contributor to morbidity and mortality globally and has been linked to an increased risk of dementia. Previous studies within the Betula cohort in Northern Sweden have demonstrated associations between air pollution and dementia, as well as distinctive me...
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Umeå universitet, Institutionen för folkhälsa och klinisk medicin
2024
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ftumeauniv:oai:DiVA.org:umu-229278 2024-09-30T14:40:20+00:00 Metabolic profiles associated with exposure to ambient particulate air pollution : findings from the Betula cohort Raza, Wasif Öhman, Anders Kanninen, Katja M. Jalava, Pasi Zeng, Xiao-Wen de Crom, Tosca O. E. Ikram, M. Arfan Oudin, Anna 2024 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-229278 https://doi.org/10.3389/fpubh.2024.1401006 eng eng UmeÃ¥ universitet, Institutionen för folkhälsa och klinisk medicin UmeÃ¥ universitet, Institutionen för medicinsk och translationell biologi A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, China Department of Laboratory Medicine, Lund University, Lund, Sweden Frontiers in Public Health, 2024, 12, http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-229278 doi:10.3389/fpubh.2024.1401006 PMID 39193206 Scopus 2-s2.0-85202189297 info:eu-repo/semantics/openAccess air pollution cognitive disorders dementia environmental epidemiology metabolomics Occupational Health and Environmental Health Arbetsmedicin och miljömedicin Article in journal info:eu-repo/semantics/article text 2024 ftumeauniv https://doi.org/10.3389/fpubh.2024.1401006 2024-09-10T14:19:20Z Introduction: Air pollution is a significant contributor to morbidity and mortality globally and has been linked to an increased risk of dementia. Previous studies within the Betula cohort in Northern Sweden have demonstrated associations between air pollution and dementia, as well as distinctive metabolomic profiles in dementia patients compared to controls. This study aimed to investigate whether air pollution is associated with quantitative changes in metabolite levels within this cohort, and whether future dementia status would modify this association. Methods: Both short-term and long-term exposure to air pollution were evaluated using high spatial resolution models and measured data. Air pollution from vehicle exhaust and woodsmoke were analyzed separately. Metabolomic profiling was conducted on 321 participants, including 58 serum samples from dementia patients and a control group matched for age, sex, and education level, using nuclear magnetic resonance spectroscopy. Results: No statistically significant associations were found between any metabolites and any measures of short-term or long-term exposure to air pollution. However, there were trends potentially suggesting associations between both long-term and short-term exposure to air pollution with lactate and glucose metabolites. Notably, these associations were observed despite the lack of correlation between long-term and short-term air pollution exposure in this cohort. There were also tendencies for associations between air pollution from woodsmoke to be more pronounced in participants that would later develop dementia, suggesting a potential effect depending on urban/rural factors. Discussion: While no significant associations were found, the trends observed in the data suggest potential links between air pollution exposure and changes in lactate and glucose metabolites. These findings provide some new insights into the link between air pollution and metabolic markers in a low-exposure setting. However, addressing existing limitations is crucial ... Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Frontiers in Public Health 12 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
air pollution cognitive disorders dementia environmental epidemiology metabolomics Occupational Health and Environmental Health Arbetsmedicin och miljömedicin |
spellingShingle |
air pollution cognitive disorders dementia environmental epidemiology metabolomics Occupational Health and Environmental Health Arbetsmedicin och miljömedicin Raza, Wasif Öhman, Anders Kanninen, Katja M. Jalava, Pasi Zeng, Xiao-Wen de Crom, Tosca O. E. Ikram, M. Arfan Oudin, Anna Metabolic profiles associated with exposure to ambient particulate air pollution : findings from the Betula cohort |
topic_facet |
air pollution cognitive disorders dementia environmental epidemiology metabolomics Occupational Health and Environmental Health Arbetsmedicin och miljömedicin |
description |
Introduction: Air pollution is a significant contributor to morbidity and mortality globally and has been linked to an increased risk of dementia. Previous studies within the Betula cohort in Northern Sweden have demonstrated associations between air pollution and dementia, as well as distinctive metabolomic profiles in dementia patients compared to controls. This study aimed to investigate whether air pollution is associated with quantitative changes in metabolite levels within this cohort, and whether future dementia status would modify this association. Methods: Both short-term and long-term exposure to air pollution were evaluated using high spatial resolution models and measured data. Air pollution from vehicle exhaust and woodsmoke were analyzed separately. Metabolomic profiling was conducted on 321 participants, including 58 serum samples from dementia patients and a control group matched for age, sex, and education level, using nuclear magnetic resonance spectroscopy. Results: No statistically significant associations were found between any metabolites and any measures of short-term or long-term exposure to air pollution. However, there were trends potentially suggesting associations between both long-term and short-term exposure to air pollution with lactate and glucose metabolites. Notably, these associations were observed despite the lack of correlation between long-term and short-term air pollution exposure in this cohort. There were also tendencies for associations between air pollution from woodsmoke to be more pronounced in participants that would later develop dementia, suggesting a potential effect depending on urban/rural factors. Discussion: While no significant associations were found, the trends observed in the data suggest potential links between air pollution exposure and changes in lactate and glucose metabolites. These findings provide some new insights into the link between air pollution and metabolic markers in a low-exposure setting. However, addressing existing limitations is crucial ... |
format |
Article in Journal/Newspaper |
author |
Raza, Wasif Öhman, Anders Kanninen, Katja M. Jalava, Pasi Zeng, Xiao-Wen de Crom, Tosca O. E. Ikram, M. Arfan Oudin, Anna |
author_facet |
Raza, Wasif Öhman, Anders Kanninen, Katja M. Jalava, Pasi Zeng, Xiao-Wen de Crom, Tosca O. E. Ikram, M. Arfan Oudin, Anna |
author_sort |
Raza, Wasif |
title |
Metabolic profiles associated with exposure to ambient particulate air pollution : findings from the Betula cohort |
title_short |
Metabolic profiles associated with exposure to ambient particulate air pollution : findings from the Betula cohort |
title_full |
Metabolic profiles associated with exposure to ambient particulate air pollution : findings from the Betula cohort |
title_fullStr |
Metabolic profiles associated with exposure to ambient particulate air pollution : findings from the Betula cohort |
title_full_unstemmed |
Metabolic profiles associated with exposure to ambient particulate air pollution : findings from the Betula cohort |
title_sort |
metabolic profiles associated with exposure to ambient particulate air pollution : findings from the betula cohort |
publisher |
Umeå universitet, Institutionen för folkhälsa och klinisk medicin |
publishDate |
2024 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-229278 https://doi.org/10.3389/fpubh.2024.1401006 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Frontiers in Public Health, 2024, 12, http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-229278 doi:10.3389/fpubh.2024.1401006 PMID 39193206 Scopus 2-s2.0-85202189297 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3389/fpubh.2024.1401006 |
container_title |
Frontiers in Public Health |
container_volume |
12 |
_version_ |
1811642830667382784 |