Left atrial and renal functional status as drivers of adverse outcome in heart failure with reduced ejection fraction : a four-chamber deformation study in a small cohort of northern Sweden
In a small cohort of patients (58 ± 12 years) with heart failure and reduced ejection fraction (HFREF), we have analyzed myocardial mechanics in all the four principal cardiac chambers to investigate the prognostic value of left atrial (LA) remodeling. We have also studied to investigate a possible...
Published in: | Journal of The Indian Academy of Echocardiography & Cardiovascular Imaging |
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Umeå universitet, Institutionen för folkhälsa och klinisk medicin
2020
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-224929 https://doi.org/10.4103/jiae.jiae_37_20 |
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ftumeauniv:oai:DiVA.org:umu-224929 2024-06-23T07:55:37+00:00 Left atrial and renal functional status as drivers of adverse outcome in heart failure with reduced ejection fraction : a four-chamber deformation study in a small cohort of northern Sweden Saha, Samir Kanti Kiotsekoglou, Anatoli Govind, Satish C. Lindmark, Krister 2020 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-224929 https://doi.org/10.4103/jiae.jiae_37_20 eng eng UmeÃ¥ universitet, Institutionen för folkhälsa och klinisk medicin Narayana Institute of Cardiac Sciences, Karnataka, Bengaluru, India , 2020, 4:2, s. 176-183 Journal of the Indian Academy of Echocardiography and Cardiovascular Imaging, 2543-1463, 2020, 4:2, s. 176-183 orcid:0000-0003-4599-6377 orcid:0000-0002-5756-7791 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-224929 doi:10.4103/jiae.jiae_37_20 Scopus 2-s2.0-85193402956 info:eu-repo/semantics/openAccess Global longitudinal strain heart failure left atrial strain right ventricular strain Cardiac and Cardiovascular Systems Kardiologi Article in journal info:eu-repo/semantics/article text 2020 ftumeauniv https://doi.org/10.4103/jiae.jiae_37_20 2024-06-04T23:49:29Z In a small cohort of patients (58 ± 12 years) with heart failure and reduced ejection fraction (HFREF), we have analyzed myocardial mechanics in all the four principal cardiac chambers to investigate the prognostic value of left atrial (LA) remodeling. We have also studied to investigate a possible prognostic role of the biochemical markers, such as estimated glomerular filtration rate (eGFR, mL/min/1.73 m 2) and N-terminal pro-brain natriuretic peptide (NT-proBNP). We used two-dimensional speckle tracking echocardiography to compute cardiac deformation in addition to measuring LA reservoir strain using two algorithms based on the type of electrocardiogram gating protocol chosen. The data have shown that not only four-chamber strain was significantly lower in HFREF compared with the controls but also LA strain predicted an adverse outcome. In addition, in the subgroup analysis, eGFR was significantly lower in patients with adverse outcome (death or cardiac transplantation). Interestingly, the contribution of the renal biomarker was as significant as NT-proBNP in this regard. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Journal of The Indian Academy of Echocardiography & Cardiovascular Imaging 4 2 176 183 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Global longitudinal strain heart failure left atrial strain right ventricular strain Cardiac and Cardiovascular Systems Kardiologi |
spellingShingle |
Global longitudinal strain heart failure left atrial strain right ventricular strain Cardiac and Cardiovascular Systems Kardiologi Saha, Samir Kanti Kiotsekoglou, Anatoli Govind, Satish C. Lindmark, Krister Left atrial and renal functional status as drivers of adverse outcome in heart failure with reduced ejection fraction : a four-chamber deformation study in a small cohort of northern Sweden |
topic_facet |
Global longitudinal strain heart failure left atrial strain right ventricular strain Cardiac and Cardiovascular Systems Kardiologi |
description |
In a small cohort of patients (58 ± 12 years) with heart failure and reduced ejection fraction (HFREF), we have analyzed myocardial mechanics in all the four principal cardiac chambers to investigate the prognostic value of left atrial (LA) remodeling. We have also studied to investigate a possible prognostic role of the biochemical markers, such as estimated glomerular filtration rate (eGFR, mL/min/1.73 m 2) and N-terminal pro-brain natriuretic peptide (NT-proBNP). We used two-dimensional speckle tracking echocardiography to compute cardiac deformation in addition to measuring LA reservoir strain using two algorithms based on the type of electrocardiogram gating protocol chosen. The data have shown that not only four-chamber strain was significantly lower in HFREF compared with the controls but also LA strain predicted an adverse outcome. In addition, in the subgroup analysis, eGFR was significantly lower in patients with adverse outcome (death or cardiac transplantation). Interestingly, the contribution of the renal biomarker was as significant as NT-proBNP in this regard. |
format |
Article in Journal/Newspaper |
author |
Saha, Samir Kanti Kiotsekoglou, Anatoli Govind, Satish C. Lindmark, Krister |
author_facet |
Saha, Samir Kanti Kiotsekoglou, Anatoli Govind, Satish C. Lindmark, Krister |
author_sort |
Saha, Samir Kanti |
title |
Left atrial and renal functional status as drivers of adverse outcome in heart failure with reduced ejection fraction : a four-chamber deformation study in a small cohort of northern Sweden |
title_short |
Left atrial and renal functional status as drivers of adverse outcome in heart failure with reduced ejection fraction : a four-chamber deformation study in a small cohort of northern Sweden |
title_full |
Left atrial and renal functional status as drivers of adverse outcome in heart failure with reduced ejection fraction : a four-chamber deformation study in a small cohort of northern Sweden |
title_fullStr |
Left atrial and renal functional status as drivers of adverse outcome in heart failure with reduced ejection fraction : a four-chamber deformation study in a small cohort of northern Sweden |
title_full_unstemmed |
Left atrial and renal functional status as drivers of adverse outcome in heart failure with reduced ejection fraction : a four-chamber deformation study in a small cohort of northern Sweden |
title_sort |
left atrial and renal functional status as drivers of adverse outcome in heart failure with reduced ejection fraction : a four-chamber deformation study in a small cohort of northern sweden |
publisher |
Umeå universitet, Institutionen för folkhälsa och klinisk medicin |
publishDate |
2020 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-224929 https://doi.org/10.4103/jiae.jiae_37_20 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
, 2020, 4:2, s. 176-183 Journal of the Indian Academy of Echocardiography and Cardiovascular Imaging, 2543-1463, 2020, 4:2, s. 176-183 orcid:0000-0003-4599-6377 orcid:0000-0002-5756-7791 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-224929 doi:10.4103/jiae.jiae_37_20 Scopus 2-s2.0-85193402956 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.4103/jiae.jiae_37_20 |
container_title |
Journal of The Indian Academy of Echocardiography & Cardiovascular Imaging |
container_volume |
4 |
container_issue |
2 |
container_start_page |
176 |
op_container_end_page |
183 |
_version_ |
1802648271020097536 |