First attack of acute pancreatitis in Sweden 1988 - 2003 : incidence, aetiological classification, procedures and mortality - a register study
BACKGROUND: Population-based studies suggest that the incidence of first attack of acute pancreatitis (FAAP) is increasing and that old age is associated with increased mortality. Because nationwide data are limited and information on standardized mortality ratio (SMR) versus age is lacking, we want...
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Umeå universitet, Kirurgi
2009
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ftumeauniv:oai:DiVA.org:umu-22372 2023-05-15T17:45:14+02:00 First attack of acute pancreatitis in Sweden 1988 - 2003 : incidence, aetiological classification, procedures and mortality - a register study Sandzén, Birger Rosenmüller, Mats Haapamäki, Markku M Nilsson, Erik Stenlund, Hans C Öman, Mikael 2009 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22372 https://doi.org/10.1186/1471-230X-9-18 eng eng Umeå universitet, Kirurgi Umeå universitet, Epidemiologi och global hälsa BMC Gastroenterology, 1471-230X, 2009, 9, s. 18- http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22372 doi:10.1186/1471-230X-9-18 PMID 19265519 ISI:000265762400001 info:eu-repo/semantics/openAccess Gastroenterology and Hepatology Gastroenterologi Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Article in journal info:eu-repo/semantics/article text 2009 ftumeauniv https://doi.org/10.1186/1471-230X-9-18 2022-05-01T08:18:33Z BACKGROUND: Population-based studies suggest that the incidence of first attack of acute pancreatitis (FAAP) is increasing and that old age is associated with increased mortality. Because nationwide data are limited and information on standardized mortality ratio (SMR) versus age is lacking, we wanted to describe incidence and mortality of first attack acute pancreatitis (FAAP) in Sweden. METHODS: Hospital discharge data concerning diagnoses and surgical procedures and death certificate data were linked for patients with FAAP in Sweden. Mortality was calculated as case fatality rate (CFR), i.e. deaths per 1000 patients and SMR using age-, gender- and calendar year-specific expected survival estimates, and is given as mean with 95% confidence intervals. Data are presented as median values with 25% and 75% percentiles, means and standard deviations, or proportions. Proportions have been compared using the chi square test, Poisson-regression test or Fisher exact test. Location of two groups of ratio scale variables were compared using independent samples t-test or Mann-Whitney U-test. RESULTS: From 1988 through 2003, 43415 patients (23801 men and 19614 women) were admitted for FAAP. Age adjusted incidence rose from 27.0 to 32.0 per 100000 individuals and year. Incidence increased with age for both men and women. At index stay 19.7% of men and 35.4% of women had biliary diagnoses, and 7.1% of men and 2.1% of women alcohol-related diagnoses. Of 10072 patients who underwent cholecystectomy, 7521 (74.7%) did so after index stay within the audit period. With increasing age CFR increased and SMR decreased. For the whole period studied SMR was 11.75 (11.34-12.17) within 90 days of index admission and 2.03 (1.93-2.13) from 91 to 365 days. Alcohol-related diagnoses and young age was associated with increased SMR. Length of stay and SMR decreased significantly during the audit period. CONCLUSION: Incidence of FAAP increased slightly from 1988 to 2003. Incidence increased and SMR declined with increasing patient age. Although the prognosis for patients with FAAP has improved it remains an important health problem. Aetiological classification at index stay and timing of cholecystectomy should be improved. The study was supported by the County Councils of Northern Sweden (Norrlandstingens Regionforbund). The funding body had no influence on study design; in the collection, analysis, and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) BMC Gastroenterology 9 1 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Gastroenterology and Hepatology Gastroenterologi Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
spellingShingle |
Gastroenterology and Hepatology Gastroenterologi Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Sandzén, Birger Rosenmüller, Mats Haapamäki, Markku M Nilsson, Erik Stenlund, Hans C Öman, Mikael First attack of acute pancreatitis in Sweden 1988 - 2003 : incidence, aetiological classification, procedures and mortality - a register study |
topic_facet |
Gastroenterology and Hepatology Gastroenterologi Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
description |
BACKGROUND: Population-based studies suggest that the incidence of first attack of acute pancreatitis (FAAP) is increasing and that old age is associated with increased mortality. Because nationwide data are limited and information on standardized mortality ratio (SMR) versus age is lacking, we wanted to describe incidence and mortality of first attack acute pancreatitis (FAAP) in Sweden. METHODS: Hospital discharge data concerning diagnoses and surgical procedures and death certificate data were linked for patients with FAAP in Sweden. Mortality was calculated as case fatality rate (CFR), i.e. deaths per 1000 patients and SMR using age-, gender- and calendar year-specific expected survival estimates, and is given as mean with 95% confidence intervals. Data are presented as median values with 25% and 75% percentiles, means and standard deviations, or proportions. Proportions have been compared using the chi square test, Poisson-regression test or Fisher exact test. Location of two groups of ratio scale variables were compared using independent samples t-test or Mann-Whitney U-test. RESULTS: From 1988 through 2003, 43415 patients (23801 men and 19614 women) were admitted for FAAP. Age adjusted incidence rose from 27.0 to 32.0 per 100000 individuals and year. Incidence increased with age for both men and women. At index stay 19.7% of men and 35.4% of women had biliary diagnoses, and 7.1% of men and 2.1% of women alcohol-related diagnoses. Of 10072 patients who underwent cholecystectomy, 7521 (74.7%) did so after index stay within the audit period. With increasing age CFR increased and SMR decreased. For the whole period studied SMR was 11.75 (11.34-12.17) within 90 days of index admission and 2.03 (1.93-2.13) from 91 to 365 days. Alcohol-related diagnoses and young age was associated with increased SMR. Length of stay and SMR decreased significantly during the audit period. CONCLUSION: Incidence of FAAP increased slightly from 1988 to 2003. Incidence increased and SMR declined with increasing patient age. Although the prognosis for patients with FAAP has improved it remains an important health problem. Aetiological classification at index stay and timing of cholecystectomy should be improved. The study was supported by the County Councils of Northern Sweden (Norrlandstingens Regionforbund). The funding body had no influence on study design; in the collection, analysis, and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. |
format |
Article in Journal/Newspaper |
author |
Sandzén, Birger Rosenmüller, Mats Haapamäki, Markku M Nilsson, Erik Stenlund, Hans C Öman, Mikael |
author_facet |
Sandzén, Birger Rosenmüller, Mats Haapamäki, Markku M Nilsson, Erik Stenlund, Hans C Öman, Mikael |
author_sort |
Sandzén, Birger |
title |
First attack of acute pancreatitis in Sweden 1988 - 2003 : incidence, aetiological classification, procedures and mortality - a register study |
title_short |
First attack of acute pancreatitis in Sweden 1988 - 2003 : incidence, aetiological classification, procedures and mortality - a register study |
title_full |
First attack of acute pancreatitis in Sweden 1988 - 2003 : incidence, aetiological classification, procedures and mortality - a register study |
title_fullStr |
First attack of acute pancreatitis in Sweden 1988 - 2003 : incidence, aetiological classification, procedures and mortality - a register study |
title_full_unstemmed |
First attack of acute pancreatitis in Sweden 1988 - 2003 : incidence, aetiological classification, procedures and mortality - a register study |
title_sort |
first attack of acute pancreatitis in sweden 1988 - 2003 : incidence, aetiological classification, procedures and mortality - a register study |
publisher |
Umeå universitet, Kirurgi |
publishDate |
2009 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22372 https://doi.org/10.1186/1471-230X-9-18 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
BMC Gastroenterology, 1471-230X, 2009, 9, s. 18- http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22372 doi:10.1186/1471-230X-9-18 PMID 19265519 ISI:000265762400001 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/1471-230X-9-18 |
container_title |
BMC Gastroenterology |
container_volume |
9 |
container_issue |
1 |
_version_ |
1766148088144068608 |