Beyond the established risk factors of myocardial infarction : lifestyle factors and novel biomarkers
Age, male sex, hypertension, smoking, diabetes, dyslipidaemia, and obesity are considered as established risk factors for cardiovascular diseases. Several of these established cardiovascular risk factors are strongly influenced by lifestyle. Novel biomarkers from different mechanistic pathways have...
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ftumeauniv:oai:DiVA.org:umu-21849 2023-10-09T21:54:37+02:00 Beyond the established risk factors of myocardial infarction : lifestyle factors and novel biomarkers Wennberg, Patrik 2009 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-21849 eng eng Allmänmedicin Umeå : Folkhälsa och klinisk medicin Umeå University medical dissertations, 0346-6612 1245 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-21849 urn:isbn:978-91-7264-722-0 info:eu-repo/semantics/openAccess lifestyle factors physical activity commuting activity leisure time physical activity occupational physical activity snuff use haemostatic markers inflammatory markers myocardial infarction epidemiology primary prevention General Practice Allmänmedicin Doctoral thesis, comprehensive summary info:eu-repo/semantics/doctoralThesis text 2009 ftumeauniv 2023-09-22T13:51:48Z Age, male sex, hypertension, smoking, diabetes, dyslipidaemia, and obesity are considered as established risk factors for cardiovascular diseases. Several of these established cardiovascular risk factors are strongly influenced by lifestyle. Novel biomarkers from different mechanistic pathways have been associated with cardiovascular risk, but their clinical utility is still uncertain. The overall objective of the thesis was to evaluate the associations between certain lifestyle factors (physical activity and snuff use), biomarkers reflecting the haemostatic and the inflammatory systems and risk of a future first-ever myocardial infarction. A prospective incident nested case-control study design was used with a total of 651 cases of myocardial infarction and 2238 matched controls from the population-based Northern Sweden Health and Disease Study. The effects of commuting activity, occupational and leisure time physical activity on risk of myocardial infarction were studied. A clearly increased risk of myocardial infarction was found for car commuting compared to active commuting (walking, cycling or going by bus). High versus low leisure time physical activity was associated with decreased risk of myocardial infarction. Low occupational physical activity was associated with risk of myocardial infarction in men. The risk of myocardial infarction or sudden cardiac death was studied in male snuff users compared to non-tobacco users. No increased risk was found for myocardial infarction or sudden cardiac death among snuff users without a previous history of smoking. However, for sudden cardiac death the study did not have statistical power to detect small differences in risk. Plasma levels of haemostatic markers have previously shown to be associated with risk of myocardial infarction, but as haemostatic markers are also acute-phase reactants, it is not clear if their association with myocardial infarction is independent of inflammatory markers. In the present study, the haemostatic markers D-dimer, von Willebrand ... Doctoral or Postdoctoral Thesis Northern Sweden Umeå University: Publications (DiVA) |
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Open Polar |
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Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
lifestyle factors physical activity commuting activity leisure time physical activity occupational physical activity snuff use haemostatic markers inflammatory markers myocardial infarction epidemiology primary prevention General Practice Allmänmedicin |
spellingShingle |
lifestyle factors physical activity commuting activity leisure time physical activity occupational physical activity snuff use haemostatic markers inflammatory markers myocardial infarction epidemiology primary prevention General Practice Allmänmedicin Wennberg, Patrik Beyond the established risk factors of myocardial infarction : lifestyle factors and novel biomarkers |
topic_facet |
lifestyle factors physical activity commuting activity leisure time physical activity occupational physical activity snuff use haemostatic markers inflammatory markers myocardial infarction epidemiology primary prevention General Practice Allmänmedicin |
description |
Age, male sex, hypertension, smoking, diabetes, dyslipidaemia, and obesity are considered as established risk factors for cardiovascular diseases. Several of these established cardiovascular risk factors are strongly influenced by lifestyle. Novel biomarkers from different mechanistic pathways have been associated with cardiovascular risk, but their clinical utility is still uncertain. The overall objective of the thesis was to evaluate the associations between certain lifestyle factors (physical activity and snuff use), biomarkers reflecting the haemostatic and the inflammatory systems and risk of a future first-ever myocardial infarction. A prospective incident nested case-control study design was used with a total of 651 cases of myocardial infarction and 2238 matched controls from the population-based Northern Sweden Health and Disease Study. The effects of commuting activity, occupational and leisure time physical activity on risk of myocardial infarction were studied. A clearly increased risk of myocardial infarction was found for car commuting compared to active commuting (walking, cycling or going by bus). High versus low leisure time physical activity was associated with decreased risk of myocardial infarction. Low occupational physical activity was associated with risk of myocardial infarction in men. The risk of myocardial infarction or sudden cardiac death was studied in male snuff users compared to non-tobacco users. No increased risk was found for myocardial infarction or sudden cardiac death among snuff users without a previous history of smoking. However, for sudden cardiac death the study did not have statistical power to detect small differences in risk. Plasma levels of haemostatic markers have previously shown to be associated with risk of myocardial infarction, but as haemostatic markers are also acute-phase reactants, it is not clear if their association with myocardial infarction is independent of inflammatory markers. In the present study, the haemostatic markers D-dimer, von Willebrand ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Wennberg, Patrik |
author_facet |
Wennberg, Patrik |
author_sort |
Wennberg, Patrik |
title |
Beyond the established risk factors of myocardial infarction : lifestyle factors and novel biomarkers |
title_short |
Beyond the established risk factors of myocardial infarction : lifestyle factors and novel biomarkers |
title_full |
Beyond the established risk factors of myocardial infarction : lifestyle factors and novel biomarkers |
title_fullStr |
Beyond the established risk factors of myocardial infarction : lifestyle factors and novel biomarkers |
title_full_unstemmed |
Beyond the established risk factors of myocardial infarction : lifestyle factors and novel biomarkers |
title_sort |
beyond the established risk factors of myocardial infarction : lifestyle factors and novel biomarkers |
publisher |
Allmänmedicin |
publishDate |
2009 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-21849 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Umeå University medical dissertations, 0346-6612 1245 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-21849 urn:isbn:978-91-7264-722-0 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1779318266894745600 |