Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer
Purpose: Sarcopenia and myosteatosis, quantified via computed tomography (CT), are associated with poor colorectal cancer outcomes. These body composition estimates can be influenced by physical exercise. We explored the correlation between pre-diagnostic physical exercise, body composition close to...
Published in: | International Journal of Colorectal Disease |
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Language: | English |
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Umeå universitet, Kirurgi
2023
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215081 https://doi.org/10.1007/s00384-023-04536-0 |
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ftumeauniv:oai:DiVA.org:umu-215081 2023-11-12T04:23:24+01:00 Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer Renman, David van Guelpen, Bethany Anderson, Fredrick Axelsson, Jan Riklund, Katrine Strigård, Karin Palmqvist, Richard Gunnarsson, Ulf Gylling, Björn 2023 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215081 https://doi.org/10.1007/s00384-023-04536-0 eng eng Umeå universitet, Kirurgi Umeå universitet, Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM) Umeå universitet, Onkologi Umeå universitet, Radiofysik Umeå universitet, Diagnostisk radiologi Umeå universitet, Patologi International Journal of Colorectal Disease, 0179-1958, 2023, 38:1, orcid:0000-0002-9045-6946 orcid:0000-0002-9692-101X orcid:0000-0002-3731-3612 orcid:0000-0001-5227-8117 orcid:0000-0001-5838-9133 orcid:0000-0002-9933-2843 orcid:0000-0002-3806-2114 orcid:0000-0002-4688-8952 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215081 doi:10.1007/s00384-023-04536-0 PMID 37755537 Scopus 2-s2.0-85172659066 info:eu-repo/semantics/openAccess Colorectal cancer Exercise Myosteatosis Physical activity Sarcopenia Cancer and Oncology Cancer och onkologi Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Article in journal info:eu-repo/semantics/article text 2023 ftumeauniv https://doi.org/10.1007/s00384-023-04536-0 2023-10-18T22:36:25Z Purpose: Sarcopenia and myosteatosis, quantified via computed tomography (CT), are associated with poor colorectal cancer outcomes. These body composition estimates can be influenced by physical exercise. We explored the correlation between pre-diagnostic physical exercise, body composition close to diagnosis, and the combined prognosis impact of these factors. Methods: We studied 519 stage I–III colorectal cancer (CRC) cases diagnosed 2000–2016 with pre-diagnostic self-reported recreational physical exercise data collected in the prospective, population-based Northern Sweden Health and Disease Study, and CT-estimated skeletal muscle index (SMI) or skeletal muscle density (SMD). Risk estimates were calculated by multivariable logistic regression and Cox proportional hazards models. Results: No association was seen between low pre-diagnostic physical exercise and sarcopenia/myosteatosis in the multivariable model adjusted for age, sex, educational level, tumor stage, and tumor location. In multivariable Cox regression models, the combination of low pre-diagnostic physical exercise and either sarcopenia or myosteatosis at the time of diagnosis was associated with cancer-specific mortality compared to the reference group of high physical exercise combined with no sarcopenia/myosteatosis (adjusted HR 1.94 95% CI 1.00–3.76 for sarcopenia and adjusted HR 2.39 95% CI 1.16–4.94 for myosteatosis). Conclusions: The combined presence of low pre-diagnostic physical exercise and sarcopenia or myosteatosis was associated with increased CRC-specific mortality. Despite the positive effect on prognosis, physical exercise did not alter body composition estimates at diagnosis, which could indicate attenuation from other factors. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) International Journal of Colorectal Disease 38 1 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Colorectal cancer Exercise Myosteatosis Physical activity Sarcopenia Cancer and Oncology Cancer och onkologi Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
spellingShingle |
Colorectal cancer Exercise Myosteatosis Physical activity Sarcopenia Cancer and Oncology Cancer och onkologi Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Renman, David van Guelpen, Bethany Anderson, Fredrick Axelsson, Jan Riklund, Katrine Strigård, Karin Palmqvist, Richard Gunnarsson, Ulf Gylling, Björn Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer |
topic_facet |
Colorectal cancer Exercise Myosteatosis Physical activity Sarcopenia Cancer and Oncology Cancer och onkologi Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
description |
Purpose: Sarcopenia and myosteatosis, quantified via computed tomography (CT), are associated with poor colorectal cancer outcomes. These body composition estimates can be influenced by physical exercise. We explored the correlation between pre-diagnostic physical exercise, body composition close to diagnosis, and the combined prognosis impact of these factors. Methods: We studied 519 stage I–III colorectal cancer (CRC) cases diagnosed 2000–2016 with pre-diagnostic self-reported recreational physical exercise data collected in the prospective, population-based Northern Sweden Health and Disease Study, and CT-estimated skeletal muscle index (SMI) or skeletal muscle density (SMD). Risk estimates were calculated by multivariable logistic regression and Cox proportional hazards models. Results: No association was seen between low pre-diagnostic physical exercise and sarcopenia/myosteatosis in the multivariable model adjusted for age, sex, educational level, tumor stage, and tumor location. In multivariable Cox regression models, the combination of low pre-diagnostic physical exercise and either sarcopenia or myosteatosis at the time of diagnosis was associated with cancer-specific mortality compared to the reference group of high physical exercise combined with no sarcopenia/myosteatosis (adjusted HR 1.94 95% CI 1.00–3.76 for sarcopenia and adjusted HR 2.39 95% CI 1.16–4.94 for myosteatosis). Conclusions: The combined presence of low pre-diagnostic physical exercise and sarcopenia or myosteatosis was associated with increased CRC-specific mortality. Despite the positive effect on prognosis, physical exercise did not alter body composition estimates at diagnosis, which could indicate attenuation from other factors. |
format |
Article in Journal/Newspaper |
author |
Renman, David van Guelpen, Bethany Anderson, Fredrick Axelsson, Jan Riklund, Katrine Strigård, Karin Palmqvist, Richard Gunnarsson, Ulf Gylling, Björn |
author_facet |
Renman, David van Guelpen, Bethany Anderson, Fredrick Axelsson, Jan Riklund, Katrine Strigård, Karin Palmqvist, Richard Gunnarsson, Ulf Gylling, Björn |
author_sort |
Renman, David |
title |
Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer |
title_short |
Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer |
title_full |
Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer |
title_fullStr |
Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer |
title_full_unstemmed |
Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer |
title_sort |
association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer |
publisher |
Umeå universitet, Kirurgi |
publishDate |
2023 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215081 https://doi.org/10.1007/s00384-023-04536-0 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
International Journal of Colorectal Disease, 0179-1958, 2023, 38:1, orcid:0000-0002-9045-6946 orcid:0000-0002-9692-101X orcid:0000-0002-3731-3612 orcid:0000-0001-5227-8117 orcid:0000-0001-5838-9133 orcid:0000-0002-9933-2843 orcid:0000-0002-3806-2114 orcid:0000-0002-4688-8952 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215081 doi:10.1007/s00384-023-04536-0 PMID 37755537 Scopus 2-s2.0-85172659066 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1007/s00384-023-04536-0 |
container_title |
International Journal of Colorectal Disease |
container_volume |
38 |
container_issue |
1 |
_version_ |
1782338183136018432 |