Trends in renal function in Northern Sweden 1986-2014 : data from the seven cross-sectional surveys within the Northern Sweden MONICA study
Objective: The prevalence of chronic kidney disease (CKD) is increasing globally, and CKD is closely related to cardiovascular disease (CVD). CKD and CVD share several risk factors (RF), such as diabetes, hypertension, obesity and smoking, and the prevalence of these RF has changed during the last d...
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Umeå universitet, Institutionen för folkhälsa och klinisk medicin
2023
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ftumeauniv:oai:DiVA.org:umu-214628 2023-10-25T01:42:06+02:00 Trends in renal function in Northern Sweden 1986-2014 : data from the seven cross-sectional surveys within the Northern Sweden MONICA study de Man Lapidoth, Julia Hultdin, Johan Jonsson, Andreas P. Eriksson Svensson, Maria Wennberg, Maria Zeller, Tanja Söderberg, Stefan 2023 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214628 https://doi.org/10.1136/bmjopen-2023-072664 eng eng Umeå universitet, Institutionen för folkhälsa och klinisk medicin Umeå universitet, Klinisk kemi Renal Medicine, Uppsala University, Uppsala, Sweden Clinic for General and Interventional Cardiology, University of Hamburg, Hamburg, Germany; German Center of Cardiovascular Research (DZHK), Partner Seite, Hamburg, Germany BMJ Open, 2023, 13:8, info:eu-repo/grantAgreement/EC/FP7/HEALTH–F2–2011–278913 orcid:0000-0002-9599-0961 orcid:0000-0001-9225-1306 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214628 doi:10.1136/bmjopen-2023-072664 PMID 37648389 Scopus 2-s2.0-85169231018 info:eu-repo/semantics/openAccess epidemiology nephrology public health Urology and Nephrology Urologi och njurmedicin Article in journal info:eu-repo/semantics/article text 2023 ftumeauniv https://doi.org/10.1136/bmjopen-2023-072664 2023-09-27T22:36:25Z Objective: The prevalence of chronic kidney disease (CKD) is increasing globally, and CKD is closely related to cardiovascular disease (CVD). CKD and CVD share several risk factors (RF), such as diabetes, hypertension, obesity and smoking, and the prevalence of these RF has changed during the last decades, and we aimed to study the effect on renal function over time. Design: Repeated cross-sectional population-based studies. Setting: The two Northern counties (Norr- and Västerbotten) in Sweden. Participants: Within the MONitoring Trends and Determinants of CArdiovascular Disease (MONICA) study, seven surveys were performed between 1986 and 2014, including participants aged 25-64 years (n=10 185). Interventions: None. Measures: Information on anthropometry, blood pressure and cardiovascular risk factors was collected. Creatinine and cystatin C were analysed in stored blood samples and the estimated glomerular filtration rate (eGFR) calculated using the creatinine-based Lund-Malmö revised and Chronic Kidney Disease Epidemiology Collaboration (eGFR crea) equations as well as the cystatin C-based Caucasian, Asian, Paediatric and Adult cohort (CAPA) equation (eGFR cysC). Renal function over time was analysed using univariable and multivariable linear regression models. Results: Renal function, both eGFR crea and eGFR cysC, decreased over time (both p<0.001) and differed between counties and sexes. In a multivariable analysis, study year remained inversely associated with both eGFR crea and eGFR cysC (both p<0.001) after adjustment for classical cardiovascular RF. Conclusion: Renal function has deteriorated in Northern Sweden between 1986 and 2014. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) BMJ Open 13 8 e072664 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
epidemiology nephrology public health Urology and Nephrology Urologi och njurmedicin |
spellingShingle |
epidemiology nephrology public health Urology and Nephrology Urologi och njurmedicin de Man Lapidoth, Julia Hultdin, Johan Jonsson, Andreas P. Eriksson Svensson, Maria Wennberg, Maria Zeller, Tanja Söderberg, Stefan Trends in renal function in Northern Sweden 1986-2014 : data from the seven cross-sectional surveys within the Northern Sweden MONICA study |
topic_facet |
epidemiology nephrology public health Urology and Nephrology Urologi och njurmedicin |
description |
Objective: The prevalence of chronic kidney disease (CKD) is increasing globally, and CKD is closely related to cardiovascular disease (CVD). CKD and CVD share several risk factors (RF), such as diabetes, hypertension, obesity and smoking, and the prevalence of these RF has changed during the last decades, and we aimed to study the effect on renal function over time. Design: Repeated cross-sectional population-based studies. Setting: The two Northern counties (Norr- and Västerbotten) in Sweden. Participants: Within the MONitoring Trends and Determinants of CArdiovascular Disease (MONICA) study, seven surveys were performed between 1986 and 2014, including participants aged 25-64 years (n=10 185). Interventions: None. Measures: Information on anthropometry, blood pressure and cardiovascular risk factors was collected. Creatinine and cystatin C were analysed in stored blood samples and the estimated glomerular filtration rate (eGFR) calculated using the creatinine-based Lund-Malmö revised and Chronic Kidney Disease Epidemiology Collaboration (eGFR crea) equations as well as the cystatin C-based Caucasian, Asian, Paediatric and Adult cohort (CAPA) equation (eGFR cysC). Renal function over time was analysed using univariable and multivariable linear regression models. Results: Renal function, both eGFR crea and eGFR cysC, decreased over time (both p<0.001) and differed between counties and sexes. In a multivariable analysis, study year remained inversely associated with both eGFR crea and eGFR cysC (both p<0.001) after adjustment for classical cardiovascular RF. Conclusion: Renal function has deteriorated in Northern Sweden between 1986 and 2014. |
format |
Article in Journal/Newspaper |
author |
de Man Lapidoth, Julia Hultdin, Johan Jonsson, Andreas P. Eriksson Svensson, Maria Wennberg, Maria Zeller, Tanja Söderberg, Stefan |
author_facet |
de Man Lapidoth, Julia Hultdin, Johan Jonsson, Andreas P. Eriksson Svensson, Maria Wennberg, Maria Zeller, Tanja Söderberg, Stefan |
author_sort |
de Man Lapidoth, Julia |
title |
Trends in renal function in Northern Sweden 1986-2014 : data from the seven cross-sectional surveys within the Northern Sweden MONICA study |
title_short |
Trends in renal function in Northern Sweden 1986-2014 : data from the seven cross-sectional surveys within the Northern Sweden MONICA study |
title_full |
Trends in renal function in Northern Sweden 1986-2014 : data from the seven cross-sectional surveys within the Northern Sweden MONICA study |
title_fullStr |
Trends in renal function in Northern Sweden 1986-2014 : data from the seven cross-sectional surveys within the Northern Sweden MONICA study |
title_full_unstemmed |
Trends in renal function in Northern Sweden 1986-2014 : data from the seven cross-sectional surveys within the Northern Sweden MONICA study |
title_sort |
trends in renal function in northern sweden 1986-2014 : data from the seven cross-sectional surveys within the northern sweden monica study |
publisher |
Umeå universitet, Institutionen för folkhälsa och klinisk medicin |
publishDate |
2023 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214628 https://doi.org/10.1136/bmjopen-2023-072664 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
BMJ Open, 2023, 13:8, info:eu-repo/grantAgreement/EC/FP7/HEALTH–F2–2011–278913 orcid:0000-0002-9599-0961 orcid:0000-0001-9225-1306 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214628 doi:10.1136/bmjopen-2023-072664 PMID 37648389 Scopus 2-s2.0-85169231018 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1136/bmjopen-2023-072664 |
container_title |
BMJ Open |
container_volume |
13 |
container_issue |
8 |
container_start_page |
e072664 |
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1780738502229491712 |