Diabetes, prediabetes, and atrial fibrillation : a population-based cohort study based on national and regional registers
Background: Previous studies have shown an increased risk for atrial fibrillation and atrial flutter (AF) in people with type 2 diabetes and prediabetes. It is unclear whether this increase in AF risk is independent of other risk factors for AF. Objective: To investigate the association between diab...
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Umeå universitet, Institutionen för folkhälsa och klinisk medicin
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ftumeauniv:oai:DiVA.org:umu-212329 2024-04-28T08:32:39+00:00 Diabetes, prediabetes, and atrial fibrillation : a population-based cohort study based on national and regional registers Johansson, Cecilia Örtendahl, Lina Lind, Marcus M. Andersson, Jonas Johansson, Lars Brunström, Mattias 2023 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-212329 https://doi.org/10.1111/joim.13688 eng eng UmeÃ¥ universitet, Institutionen för folkhälsa och klinisk medicin Journal of Internal Medicine, 0954-6820, 2023, 294:5, s. 605-615 orcid:0000-0001-9972-5893 orcid:0000-0003-4423-4135 orcid:0000-0002-7939-0149 orcid:0000-0002-7054-0905 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-212329 doi:10.1111/joim.13688 PMID 37387643 Scopus 2-s2.0-85164804333 info:eu-repo/semantics/openAccess atrial fibrillation diabetes glucose oral glucose tolerance test prediabetes Endocrinology and Diabetes Endokrinologi och diabetes Article in journal info:eu-repo/semantics/article text 2023 ftumeauniv https://doi.org/10.1111/joim.13688 2024-04-09T23:38:33Z Background: Previous studies have shown an increased risk for atrial fibrillation and atrial flutter (AF) in people with type 2 diabetes and prediabetes. It is unclear whether this increase in AF risk is independent of other risk factors for AF. Objective: To investigate the association between diabetes and different prediabetic states, as independent risk factors for the onset of AF. Methods: We performed a population-based cohort study in Northern Sweden, including data on fasting plasma glucose, oral glucose tolerance test, major cardiovascular risk factors, medical history, and lifestyle factors. Participants were divided into six groups depending on glycemic status and followed through national registers for AF diagnosis. Cox proportional hazard model was used to assess the association between glycemic status and AF, using normoglycemia as reference. Results: The cohort consisted of 88,889 participants who underwent a total of 139,661 health examinations. In the model adjusted for age and sex, there was a significant association between glycemic status and development of AF in all groups except the impaired glucose tolerance group, with the strongest association for the group with known diabetes (p-value <0.001). In a model adjusted for sex, age, systolic blood pressure, body mass index, antihypertensive drugs, cholesterol, alcohol, smoking, education level, marital status, and physical activity, there was no significant association between glycemic status and AF. Conclusions/interpretation: The association between glycemic status and AF disappears upon adjustment for potential confounders. Diabetes and prediabetes do not appear to be independent risk factors for AF. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Journal of Internal Medicine |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
atrial fibrillation diabetes glucose oral glucose tolerance test prediabetes Endocrinology and Diabetes Endokrinologi och diabetes |
spellingShingle |
atrial fibrillation diabetes glucose oral glucose tolerance test prediabetes Endocrinology and Diabetes Endokrinologi och diabetes Johansson, Cecilia Örtendahl, Lina Lind, Marcus M. Andersson, Jonas Johansson, Lars Brunström, Mattias Diabetes, prediabetes, and atrial fibrillation : a population-based cohort study based on national and regional registers |
topic_facet |
atrial fibrillation diabetes glucose oral glucose tolerance test prediabetes Endocrinology and Diabetes Endokrinologi och diabetes |
description |
Background: Previous studies have shown an increased risk for atrial fibrillation and atrial flutter (AF) in people with type 2 diabetes and prediabetes. It is unclear whether this increase in AF risk is independent of other risk factors for AF. Objective: To investigate the association between diabetes and different prediabetic states, as independent risk factors for the onset of AF. Methods: We performed a population-based cohort study in Northern Sweden, including data on fasting plasma glucose, oral glucose tolerance test, major cardiovascular risk factors, medical history, and lifestyle factors. Participants were divided into six groups depending on glycemic status and followed through national registers for AF diagnosis. Cox proportional hazard model was used to assess the association between glycemic status and AF, using normoglycemia as reference. Results: The cohort consisted of 88,889 participants who underwent a total of 139,661 health examinations. In the model adjusted for age and sex, there was a significant association between glycemic status and development of AF in all groups except the impaired glucose tolerance group, with the strongest association for the group with known diabetes (p-value <0.001). In a model adjusted for sex, age, systolic blood pressure, body mass index, antihypertensive drugs, cholesterol, alcohol, smoking, education level, marital status, and physical activity, there was no significant association between glycemic status and AF. Conclusions/interpretation: The association between glycemic status and AF disappears upon adjustment for potential confounders. Diabetes and prediabetes do not appear to be independent risk factors for AF. |
format |
Article in Journal/Newspaper |
author |
Johansson, Cecilia Örtendahl, Lina Lind, Marcus M. Andersson, Jonas Johansson, Lars Brunström, Mattias |
author_facet |
Johansson, Cecilia Örtendahl, Lina Lind, Marcus M. Andersson, Jonas Johansson, Lars Brunström, Mattias |
author_sort |
Johansson, Cecilia |
title |
Diabetes, prediabetes, and atrial fibrillation : a population-based cohort study based on national and regional registers |
title_short |
Diabetes, prediabetes, and atrial fibrillation : a population-based cohort study based on national and regional registers |
title_full |
Diabetes, prediabetes, and atrial fibrillation : a population-based cohort study based on national and regional registers |
title_fullStr |
Diabetes, prediabetes, and atrial fibrillation : a population-based cohort study based on national and regional registers |
title_full_unstemmed |
Diabetes, prediabetes, and atrial fibrillation : a population-based cohort study based on national and regional registers |
title_sort |
diabetes, prediabetes, and atrial fibrillation : a population-based cohort study based on national and regional registers |
publisher |
Umeå universitet, Institutionen för folkhälsa och klinisk medicin |
publishDate |
2023 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-212329 https://doi.org/10.1111/joim.13688 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Journal of Internal Medicine, 0954-6820, 2023, 294:5, s. 605-615 orcid:0000-0001-9972-5893 orcid:0000-0003-4423-4135 orcid:0000-0002-7939-0149 orcid:0000-0002-7054-0905 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-212329 doi:10.1111/joim.13688 PMID 37387643 Scopus 2-s2.0-85164804333 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1111/joim.13688 |
container_title |
Journal of Internal Medicine |
_version_ |
1797589763728867328 |