Lifestyle, biomarkers and the risk of developing inflammatory bowel disease
Introduction: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic disease causing inflammation in the gut mucosa. The pathogenesis involves alteration in gut microbiota and in the intestinal barrier due to genetic factors, environmental exposure...
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Umeå universitet, Klinisk kemi
2023
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ftumeauniv:oai:DiVA.org:umu-208115 2023-10-09T21:54:39+02:00 Lifestyle, biomarkers and the risk of developing inflammatory bowel disease Livsstil, biomarkörer och risken att utveckla inflammatorisk tarmsjukdom Widbom, Lovisa 2023 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-208115 eng eng Umeå universitet, Klinisk kemi Umeå : Umeå University Umeå University medical dissertations, 0346-6612 2247 orcid:0000-0003-0787-3368 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-208115 urn:isbn:978-91-8070-035-1 urn:isbn:978-91-8070-034-4 info:eu-repo/semantics/openAccess Inflammatory bowel disease ulcerative colitis Crohn's disease smoking cotinine iron deficiency ferritin pyridoxal-5-phosphate kynurenine pathway Clinical Medicine Klinisk medicin Doctoral thesis, comprehensive summary info:eu-repo/semantics/doctoralThesis text 2023 ftumeauniv 2023-09-22T14:00:03Z Introduction: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic disease causing inflammation in the gut mucosa. The pathogenesis involves alteration in gut microbiota and in the intestinal barrier due to genetic factors, environmental exposure and dysregulation of the immune response. Several environmental risk factors and risk genes have been identified, but still, the pathogenesis is not fully understood. Methods: Included papers are all case-control studies based on previously collected data stored with the biobank in Umeå, Sweden. Cases are individuals that participated in the Northern Sweden Health and Disease Study (NSHDS) at least one year before developing IBD. Information was available for all cases regarding age, time and place for inclusion in NSHDS, height and weight, sex and tobacco use. Part of the cases also had available data from a detailed food-frequency questionnaire. For each available case, controls matched for age, sex and time and place were selected. Analysed factors included tobacco use, with smoking and snuff use analysed separately), cotinine (a metabolite of nicotine), iron status (including ferritin, iron, transferrin and transferrin saturation), B-vitamins and tryptophan metabolites. Results: Smoking was associated with an increased risk of developing IBD both based on questionnaire data and using cotinine as a marker for exposure. Snuff use was not associated with risk for developing IBD. A lower ferritin was associated with an increased risk of developing IBD, whereas no association was seen for other iron status analytes. When analysing iron deficiency based on ferritin and CRP, it was shown that iron deficiency was more common among men before onset of IBD, whereas no difference was seen for women. Active vitamin B6 was lower among cases compared to controls, as well as an index indicating functional B6 deficiency. Kynurenic acid and xanthurenic acid, both tryptophan metabolites with immunomodulatory properties, were lower ... Doctoral or Postdoctoral Thesis Northern Sweden Umeå University: Publications (DiVA) |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Inflammatory bowel disease ulcerative colitis Crohn's disease smoking cotinine iron deficiency ferritin pyridoxal-5-phosphate kynurenine pathway Clinical Medicine Klinisk medicin |
spellingShingle |
Inflammatory bowel disease ulcerative colitis Crohn's disease smoking cotinine iron deficiency ferritin pyridoxal-5-phosphate kynurenine pathway Clinical Medicine Klinisk medicin Widbom, Lovisa Lifestyle, biomarkers and the risk of developing inflammatory bowel disease |
topic_facet |
Inflammatory bowel disease ulcerative colitis Crohn's disease smoking cotinine iron deficiency ferritin pyridoxal-5-phosphate kynurenine pathway Clinical Medicine Klinisk medicin |
description |
Introduction: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic disease causing inflammation in the gut mucosa. The pathogenesis involves alteration in gut microbiota and in the intestinal barrier due to genetic factors, environmental exposure and dysregulation of the immune response. Several environmental risk factors and risk genes have been identified, but still, the pathogenesis is not fully understood. Methods: Included papers are all case-control studies based on previously collected data stored with the biobank in Umeå, Sweden. Cases are individuals that participated in the Northern Sweden Health and Disease Study (NSHDS) at least one year before developing IBD. Information was available for all cases regarding age, time and place for inclusion in NSHDS, height and weight, sex and tobacco use. Part of the cases also had available data from a detailed food-frequency questionnaire. For each available case, controls matched for age, sex and time and place were selected. Analysed factors included tobacco use, with smoking and snuff use analysed separately), cotinine (a metabolite of nicotine), iron status (including ferritin, iron, transferrin and transferrin saturation), B-vitamins and tryptophan metabolites. Results: Smoking was associated with an increased risk of developing IBD both based on questionnaire data and using cotinine as a marker for exposure. Snuff use was not associated with risk for developing IBD. A lower ferritin was associated with an increased risk of developing IBD, whereas no association was seen for other iron status analytes. When analysing iron deficiency based on ferritin and CRP, it was shown that iron deficiency was more common among men before onset of IBD, whereas no difference was seen for women. Active vitamin B6 was lower among cases compared to controls, as well as an index indicating functional B6 deficiency. Kynurenic acid and xanthurenic acid, both tryptophan metabolites with immunomodulatory properties, were lower ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Widbom, Lovisa |
author_facet |
Widbom, Lovisa |
author_sort |
Widbom, Lovisa |
title |
Lifestyle, biomarkers and the risk of developing inflammatory bowel disease |
title_short |
Lifestyle, biomarkers and the risk of developing inflammatory bowel disease |
title_full |
Lifestyle, biomarkers and the risk of developing inflammatory bowel disease |
title_fullStr |
Lifestyle, biomarkers and the risk of developing inflammatory bowel disease |
title_full_unstemmed |
Lifestyle, biomarkers and the risk of developing inflammatory bowel disease |
title_sort |
lifestyle, biomarkers and the risk of developing inflammatory bowel disease |
publisher |
Umeå universitet, Klinisk kemi |
publishDate |
2023 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-208115 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Umeå University medical dissertations, 0346-6612 2247 orcid:0000-0003-0787-3368 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-208115 urn:isbn:978-91-8070-035-1 urn:isbn:978-91-8070-034-4 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1779318326254632960 |