Modifiable lifestyle risk factors for sarcoidosis : a nested case–control study
Objective: We aimed to investigate whether obesity, tobacco use, alcohol consumption and physical inactivity are associated with sarcoidosis risk. Methods: We conducted a matched case–control study nested within the Northern Sweden Health and Disease Study. Incident sarcoidosis cases (n=165) were id...
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Umeå universitet, Avdelningen för medicin
2023
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-207865 https://doi.org/10.1183/23120541.00492-2022 |
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ftumeauniv:oai:DiVA.org:umu-207865 2023-10-09T21:54:35+02:00 Modifiable lifestyle risk factors for sarcoidosis : a nested case–control study Dehara, Marina Sachs, Michael C. Arkema, Elizabeth V. Grunewald, Johan Blomberg, Anders 2023 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-207865 https://doi.org/10.1183/23120541.00492-2022 eng eng Umeå universitet, Avdelningen för medicin Clinical Epidemiology Division, Dept of Medicine Solna, Karolinska Institutet, Stockholm, Sweden Dept of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Respiratory Medicine Division, Dept of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Respiratory Medicine, Theme Inflammation and Ageing, Karolinska University Hospital, Stockholm, Sweden European Respiratory Society (ERS) ERJ Open Research, 2023, 9:2, orcid:0000-0002-2452-7347 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-207865 doi:10.1183/23120541.00492-2022 PMID 37020842 ISI:000956544900013 Scopus 2-s2.0-85153774269 info:eu-repo/semantics/openAccess Respiratory Medicine and Allergy Lungmedicin och allergi Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Article in journal info:eu-repo/semantics/article text 2023 ftumeauniv https://doi.org/10.1183/23120541.00492-2022 2023-09-22T14:00:01Z Objective: We aimed to investigate whether obesity, tobacco use, alcohol consumption and physical inactivity are associated with sarcoidosis risk. Methods: We conducted a matched case–control study nested within the Northern Sweden Health and Disease Study. Incident sarcoidosis cases (n=165) were identified via medical records and matched to controls (n=660) on sub-cohort, sex, birth and questionnaire date (1:4). Data on lifestyle factors were obtained through questionnaires, and physical measurements of height, weight and waist were collected prior to sarcoidosis diagnosis. Conditional logistic regression estimated adjusted odds ratios with 95% confidence intervals (aOR; 95% CI). Results: Compared with never-smoking, current smoking was associated with lower sarcoidosis odds (aOR 0.48; 95% CI 0.32–0.71), and former smoking with higher odds (aOR 1.33; 95% CI 0.98–1.81). Snus use was not associated with sarcoidosis. There was an increased odds of sarcoidosis associated with obesity (aOR 1.34; 95% CI 0.94–1.92) but not with overweight (aOR 0.99; 95% CI 0.76–1.30). Compared with those who were physically inactive, those who were active had a 25% higher odds of sarcoidosis (aOR 1.25; 95% CI 0.91–1.72). No association was found with moderate alcohol consumption (aOR 0.95; 95% CI 0.56–1.62). All results were similar when cases diagnosed within 5 years after exposure assessment were excluded, except the aOR for former smoking decreased to 1.1. Conclusion: We observed a reduced sarcoidosis risk associated with smoking, which cannot be fully explained by early symptoms of sarcoidosis influencing smoking habits. Results indicate an increased risk associated with obesity, but not overweight, and being physically active. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) ERJ Open Research 9 2 00492-2022 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Respiratory Medicine and Allergy Lungmedicin och allergi Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
spellingShingle |
Respiratory Medicine and Allergy Lungmedicin och allergi Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Dehara, Marina Sachs, Michael C. Arkema, Elizabeth V. Grunewald, Johan Blomberg, Anders Modifiable lifestyle risk factors for sarcoidosis : a nested case–control study |
topic_facet |
Respiratory Medicine and Allergy Lungmedicin och allergi Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
description |
Objective: We aimed to investigate whether obesity, tobacco use, alcohol consumption and physical inactivity are associated with sarcoidosis risk. Methods: We conducted a matched case–control study nested within the Northern Sweden Health and Disease Study. Incident sarcoidosis cases (n=165) were identified via medical records and matched to controls (n=660) on sub-cohort, sex, birth and questionnaire date (1:4). Data on lifestyle factors were obtained through questionnaires, and physical measurements of height, weight and waist were collected prior to sarcoidosis diagnosis. Conditional logistic regression estimated adjusted odds ratios with 95% confidence intervals (aOR; 95% CI). Results: Compared with never-smoking, current smoking was associated with lower sarcoidosis odds (aOR 0.48; 95% CI 0.32–0.71), and former smoking with higher odds (aOR 1.33; 95% CI 0.98–1.81). Snus use was not associated with sarcoidosis. There was an increased odds of sarcoidosis associated with obesity (aOR 1.34; 95% CI 0.94–1.92) but not with overweight (aOR 0.99; 95% CI 0.76–1.30). Compared with those who were physically inactive, those who were active had a 25% higher odds of sarcoidosis (aOR 1.25; 95% CI 0.91–1.72). No association was found with moderate alcohol consumption (aOR 0.95; 95% CI 0.56–1.62). All results were similar when cases diagnosed within 5 years after exposure assessment were excluded, except the aOR for former smoking decreased to 1.1. Conclusion: We observed a reduced sarcoidosis risk associated with smoking, which cannot be fully explained by early symptoms of sarcoidosis influencing smoking habits. Results indicate an increased risk associated with obesity, but not overweight, and being physically active. |
format |
Article in Journal/Newspaper |
author |
Dehara, Marina Sachs, Michael C. Arkema, Elizabeth V. Grunewald, Johan Blomberg, Anders |
author_facet |
Dehara, Marina Sachs, Michael C. Arkema, Elizabeth V. Grunewald, Johan Blomberg, Anders |
author_sort |
Dehara, Marina |
title |
Modifiable lifestyle risk factors for sarcoidosis : a nested case–control study |
title_short |
Modifiable lifestyle risk factors for sarcoidosis : a nested case–control study |
title_full |
Modifiable lifestyle risk factors for sarcoidosis : a nested case–control study |
title_fullStr |
Modifiable lifestyle risk factors for sarcoidosis : a nested case–control study |
title_full_unstemmed |
Modifiable lifestyle risk factors for sarcoidosis : a nested case–control study |
title_sort |
modifiable lifestyle risk factors for sarcoidosis : a nested case–control study |
publisher |
Umeå universitet, Avdelningen för medicin |
publishDate |
2023 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-207865 https://doi.org/10.1183/23120541.00492-2022 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
ERJ Open Research, 2023, 9:2, orcid:0000-0002-2452-7347 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-207865 doi:10.1183/23120541.00492-2022 PMID 37020842 ISI:000956544900013 Scopus 2-s2.0-85153774269 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1183/23120541.00492-2022 |
container_title |
ERJ Open Research |
container_volume |
9 |
container_issue |
2 |
container_start_page |
00492-2022 |
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1779318218998939648 |