Early-life risk factors for development of asthma from 8 to 28 years of age : a prospective cohort study
Background: The objective was to estimate the incidence rate of asthma from age 8 to 28 years and evaluate early-life risk factors for asthma onset at different ages. Methods: In 1996, within the Obstructive Lung Disease in Northern Sweden (OLIN) studies, a cohort of 3430 schoolchildren (97% of invi...
Published in: | ERJ Open Research |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Umeå universitet, Avdelningen för hållbar hälsa
2022
|
Subjects: | |
Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-203272 https://doi.org/10.1183/23120541.00074-2022 |
id |
ftumeauniv:oai:DiVA.org:umu-203272 |
---|---|
record_format |
openpolar |
spelling |
ftumeauniv:oai:DiVA.org:umu-203272 2024-05-19T07:46:10+00:00 Early-life risk factors for development of asthma from 8 to 28 years of age : a prospective cohort study Hedman, Linnea Almqvist, Linnea Bjerg, Anders Andersson, Martin Backman, Helena Perzanowski, Matthew S. Rönmark, Eva 2022 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-203272 https://doi.org/10.1183/23120541.00074-2022 eng eng UmeÃ¥ universitet, Avdelningen för hÃ¥llbar hälsa Martina Children’s Hospital, Stockholm, Sweden Dept of Environmental Health Sciences, Mailman School of Public Health, Columbia University, NY, New York, United States European Respiratory Society ERJ Open Research, 2022, 8:4, orcid:0000-0002-1630-3167 orcid:0000-0001-7222-6402 orcid:0000-0002-0553-8067 orcid:0000-0002-2358-8754 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-203272 doi:10.1183/23120541.00074-2022 ISI:000895755200002 Scopus 2-s2.0-85141716387 info:eu-repo/semantics/openAccess Respiratory Medicine and Allergy Lungmedicin och allergi Article in journal info:eu-repo/semantics/article text 2022 ftumeauniv https://doi.org/10.1183/23120541.00074-2022 2024-04-23T23:49:17Z Background: The objective was to estimate the incidence rate of asthma from age 8 to 28 years and evaluate early-life risk factors for asthma onset at different ages. Methods: In 1996, within the Obstructive Lung Disease in Northern Sweden (OLIN) studies, a cohort of 3430 schoolchildren (97% of invited) was recruited at age 8 years to a prospective study about asthma. The cohort was followed annually from age 8 to 19 years and at 28 years by questionnaire surveys (67% of the original cohort participated). Asthma was categorised as never-asthma, onset age ⩽8 years, onset age 9–13 years, onset age 14–19 years or onset age >19 years. Results: Of the 3430 individuals in the cohort, 690 (20.1%) reported asthma in any survey. The average incidence rate was 10.0/1000 per year at ⩽8 years, 11.9/1000 per year at 9–13 years, 13.3/1000 per year at 14–19 years and 6.1/1000 per year at >19 years. The incidence was higher among boys until age 10 years, but from age 15 years, it became higher among girls. Family history of asthma, allergic sensitisation and breastfeeding <3 months were associated with asthma onset throughout the study. Low birthweight, maternal smoking during pregnancy, severe respiratory infection, rhinoconjunctivitis and eczema were associated with asthma onset ⩽8 and 9–13 years. Conclusions: The incidence of asthma was high during childhood and the teenage period, and decreased substantially during young adulthood. Early-life factors were associated with asthma onset throughout childhood but had also a lasting effect on asthma incidence until adulthood. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) ERJ Open Research 8 4 00074-2022 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Respiratory Medicine and Allergy Lungmedicin och allergi |
spellingShingle |
Respiratory Medicine and Allergy Lungmedicin och allergi Hedman, Linnea Almqvist, Linnea Bjerg, Anders Andersson, Martin Backman, Helena Perzanowski, Matthew S. Rönmark, Eva Early-life risk factors for development of asthma from 8 to 28 years of age : a prospective cohort study |
topic_facet |
Respiratory Medicine and Allergy Lungmedicin och allergi |
description |
Background: The objective was to estimate the incidence rate of asthma from age 8 to 28 years and evaluate early-life risk factors for asthma onset at different ages. Methods: In 1996, within the Obstructive Lung Disease in Northern Sweden (OLIN) studies, a cohort of 3430 schoolchildren (97% of invited) was recruited at age 8 years to a prospective study about asthma. The cohort was followed annually from age 8 to 19 years and at 28 years by questionnaire surveys (67% of the original cohort participated). Asthma was categorised as never-asthma, onset age ⩽8 years, onset age 9–13 years, onset age 14–19 years or onset age >19 years. Results: Of the 3430 individuals in the cohort, 690 (20.1%) reported asthma in any survey. The average incidence rate was 10.0/1000 per year at ⩽8 years, 11.9/1000 per year at 9–13 years, 13.3/1000 per year at 14–19 years and 6.1/1000 per year at >19 years. The incidence was higher among boys until age 10 years, but from age 15 years, it became higher among girls. Family history of asthma, allergic sensitisation and breastfeeding <3 months were associated with asthma onset throughout the study. Low birthweight, maternal smoking during pregnancy, severe respiratory infection, rhinoconjunctivitis and eczema were associated with asthma onset ⩽8 and 9–13 years. Conclusions: The incidence of asthma was high during childhood and the teenage period, and decreased substantially during young adulthood. Early-life factors were associated with asthma onset throughout childhood but had also a lasting effect on asthma incidence until adulthood. |
format |
Article in Journal/Newspaper |
author |
Hedman, Linnea Almqvist, Linnea Bjerg, Anders Andersson, Martin Backman, Helena Perzanowski, Matthew S. Rönmark, Eva |
author_facet |
Hedman, Linnea Almqvist, Linnea Bjerg, Anders Andersson, Martin Backman, Helena Perzanowski, Matthew S. Rönmark, Eva |
author_sort |
Hedman, Linnea |
title |
Early-life risk factors for development of asthma from 8 to 28 years of age : a prospective cohort study |
title_short |
Early-life risk factors for development of asthma from 8 to 28 years of age : a prospective cohort study |
title_full |
Early-life risk factors for development of asthma from 8 to 28 years of age : a prospective cohort study |
title_fullStr |
Early-life risk factors for development of asthma from 8 to 28 years of age : a prospective cohort study |
title_full_unstemmed |
Early-life risk factors for development of asthma from 8 to 28 years of age : a prospective cohort study |
title_sort |
early-life risk factors for development of asthma from 8 to 28 years of age : a prospective cohort study |
publisher |
Umeå universitet, Avdelningen för hållbar hälsa |
publishDate |
2022 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-203272 https://doi.org/10.1183/23120541.00074-2022 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
ERJ Open Research, 2022, 8:4, orcid:0000-0002-1630-3167 orcid:0000-0001-7222-6402 orcid:0000-0002-0553-8067 orcid:0000-0002-2358-8754 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-203272 doi:10.1183/23120541.00074-2022 ISI:000895755200002 Scopus 2-s2.0-85141716387 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1183/23120541.00074-2022 |
container_title |
ERJ Open Research |
container_volume |
8 |
container_issue |
4 |
container_start_page |
00074-2022 |
_version_ |
1799486298541522944 |