In search of early biomarkers in pancreatic ductal adenocarcinoma using multi-omics and bioinformatics

• Main Author: Borgmästars, Emmy
• Format: Doctoral or Postdoctoral Thesis
• Language: English
• Published: Umeå universitet, Kirurgi 2022
• Subjects: Pancreatic cancer; microRNA functional analysis; TPS; miRNomics; metabolomics; proteomics; plasma samples; early detection; risk; survival; Cancer and Oncology; Cancer och onkologi; Bioinformatics and Systems Biology; Bioinformatik och systembiologi; Omik; Northern Sweden
• Online Access: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201158

Background: Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive malignancy with a 5-year survival of 10 %. Surgery is the only curative treatment. Unfortunately, few patients are eligible for surgery due to late detection. Thus, we need ways to detect the disease at an earlier stage and for...