Snus use and mortality : associations, potential mechanisms, and socioeconomic aspects
Snus is a smokeless tobacco product made of a moist powder of ground tobacco. It is used mainly in the Nordic countries, although increasingly popular internationally. The Swedish snus tradition dates back to the seventeenth century, and it is now used daily by about 23% of the male and 6% of the fe...
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Umeå universitet, Allmänmedicin
2022
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ftumeauniv:oai:DiVA.org:umu-200748 2023-10-09T21:54:39+02:00 Snus use and mortality : associations, potential mechanisms, and socioeconomic aspects Fint som snus? : snusning, mortalitet och vad som finns däremellan Byhamre, Marja Lisa 2022 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200748 eng eng Umeå universitet, Allmänmedicin Umeå : Umeå University Umeå University medical dissertations, 0346-6612 2205 orcid:0000-0002-6731-1001 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200748 urn:isbn:978-91-7855-916-9 urn:isbn:978-91-7855-917-6 info:eu-repo/semantics/openAccess snus Swedish snuff smokeless tobacco mortality cardiovascular cancer risk factor metabolic syndrome C-reactive protein vitamin D testosterone Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Doctoral thesis, comprehensive summary info:eu-repo/semantics/doctoralThesis text 2022 ftumeauniv 2023-09-22T13:56:23Z Snus is a smokeless tobacco product made of a moist powder of ground tobacco. It is used mainly in the Nordic countries, although increasingly popular internationally. The Swedish snus tradition dates back to the seventeenth century, and it is now used daily by about 23% of the male and 6% of the female population. Snus contains high levels of nicotine as well as carcinogenic substances and microorganisms that could potentially cause adverse health effects. The physiological effects of snus use include acutely raised blood pressure and heart rate, and increased cardiac oxygen demand, while the psychological response results in alertness and anxiety reduction. The high nicotine content causes rapid onset of addiction. Previous research on snus use and health is largely inconclusive, but indicates increased risks of all-cause, cardiovascular and cancer mortality. This thesis aimed to further investigate the health effects of snus use, with a focus on mortality, potential underlying mechanisms, and the impact of socioeconomic factors. Four original papers form the base of this thesis. The first study was performed on a pooled dataset of eight Swedish cohorts (The Swedish Collaboration on Health Effects of Snus use), including over 169 000 men. We found an increased risk of all-cause (HR 1.28, 95% CI 1.20; 1.35), cardiovascular, and other cause mortality, and indications of raised cancer mortality. The second study was set within an interventional program in northern Sweden (Västerbotten Intervention Programme) and included 46 000 men and women. It showed increased mortality overall (estimates similar to first study), from cardiovascular diseases, and external causes (e.g., accidents and suicide) that remained after controlling for socioeconomic status. We found these associations in groups of varying socioeconomic background (e.g., both basic education and high-income groups), suggesting that increased mortality risks among snus users are not restricted to certain socioeconomic groups. Studies three and four ... Doctoral or Postdoctoral Thesis Northern Sweden Umeå University: Publications (DiVA) |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
snus Swedish snuff smokeless tobacco mortality cardiovascular cancer risk factor metabolic syndrome C-reactive protein vitamin D testosterone Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
spellingShingle |
snus Swedish snuff smokeless tobacco mortality cardiovascular cancer risk factor metabolic syndrome C-reactive protein vitamin D testosterone Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Byhamre, Marja Lisa Snus use and mortality : associations, potential mechanisms, and socioeconomic aspects |
topic_facet |
snus Swedish snuff smokeless tobacco mortality cardiovascular cancer risk factor metabolic syndrome C-reactive protein vitamin D testosterone Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
description |
Snus is a smokeless tobacco product made of a moist powder of ground tobacco. It is used mainly in the Nordic countries, although increasingly popular internationally. The Swedish snus tradition dates back to the seventeenth century, and it is now used daily by about 23% of the male and 6% of the female population. Snus contains high levels of nicotine as well as carcinogenic substances and microorganisms that could potentially cause adverse health effects. The physiological effects of snus use include acutely raised blood pressure and heart rate, and increased cardiac oxygen demand, while the psychological response results in alertness and anxiety reduction. The high nicotine content causes rapid onset of addiction. Previous research on snus use and health is largely inconclusive, but indicates increased risks of all-cause, cardiovascular and cancer mortality. This thesis aimed to further investigate the health effects of snus use, with a focus on mortality, potential underlying mechanisms, and the impact of socioeconomic factors. Four original papers form the base of this thesis. The first study was performed on a pooled dataset of eight Swedish cohorts (The Swedish Collaboration on Health Effects of Snus use), including over 169 000 men. We found an increased risk of all-cause (HR 1.28, 95% CI 1.20; 1.35), cardiovascular, and other cause mortality, and indications of raised cancer mortality. The second study was set within an interventional program in northern Sweden (Västerbotten Intervention Programme) and included 46 000 men and women. It showed increased mortality overall (estimates similar to first study), from cardiovascular diseases, and external causes (e.g., accidents and suicide) that remained after controlling for socioeconomic status. We found these associations in groups of varying socioeconomic background (e.g., both basic education and high-income groups), suggesting that increased mortality risks among snus users are not restricted to certain socioeconomic groups. Studies three and four ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Byhamre, Marja Lisa |
author_facet |
Byhamre, Marja Lisa |
author_sort |
Byhamre, Marja Lisa |
title |
Snus use and mortality : associations, potential mechanisms, and socioeconomic aspects |
title_short |
Snus use and mortality : associations, potential mechanisms, and socioeconomic aspects |
title_full |
Snus use and mortality : associations, potential mechanisms, and socioeconomic aspects |
title_fullStr |
Snus use and mortality : associations, potential mechanisms, and socioeconomic aspects |
title_full_unstemmed |
Snus use and mortality : associations, potential mechanisms, and socioeconomic aspects |
title_sort |
snus use and mortality : associations, potential mechanisms, and socioeconomic aspects |
publisher |
Umeå universitet, Allmänmedicin |
publishDate |
2022 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200748 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Umeå University medical dissertations, 0346-6612 2205 orcid:0000-0002-6731-1001 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200748 urn:isbn:978-91-7855-916-9 urn:isbn:978-91-7855-917-6 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1779318319899213824 |