Cohort profile : the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort
PURPOSE: The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, particularly allergies and respiratory health, (2) identify susceptible time windows...
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Umeå universitet, Avdelningen för hållbar hälsa
2022
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199254 https://doi.org/10.1136/bmjopen-2021-059434 |
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ftumeauniv:oai:DiVA.org:umu-199254 2023-10-09T21:52:51+02:00 Cohort profile : the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort Svanes, Cecilie Johannessen, Ane Jacobsen Bertelsen, Randi Dharmage, Shyamali Benediktsdottir, Bryndis Bråbäck, Lennart Gislason, Thorarinn Holm, Mathias Jõgi, Oskar Lodge, Caroline J. Malinovschi, Andrei Martinez-Moratalla, Jesus Oudin, Anna Sánchez-Ramos, José Luis Timm, Signe Janson, Christer Real, Francisco Gomez Schlünssen, Vivi 2022 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199254 https://doi.org/10.1136/bmjopen-2021-059434 eng eng Umeå universitet, Avdelningen för hållbar hälsa BMJ Open, 2022, 12:6, http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199254 doi:10.1136/bmjopen-2021-059434 PMID 35654464 ISI:000807081800035 Scopus 2-s2.0-85131231942 info:eu-repo/semantics/openAccess Allergy Asthma Chronic airways disease Epidemiology Public health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Article in journal info:eu-repo/semantics/article text 2022 ftumeauniv https://doi.org/10.1136/bmjopen-2021-059434 2023-09-22T14:01:01Z PURPOSE: The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, particularly allergies and respiratory health, (2) identify susceptible time windows and (3) explore underlying mechanisms. The ultimate aim is to facilitate efficient intervention strategies targeting multiple generations. PARTICIPANTS: RHINESSA includes study participants of multiple generations from ten study centres in Norway (1), Denmark (1), Sweden (3), Iceland (1), Estonia (1), Spain (2) and Australia (1). The RHINESSA core cohort, adult offspring generation 3 (G3), was first investigated in 2014-17 in a questionnaire study (N=8818, age 18-53 years) and a clinical study (subsample, n=1405). Their G2 parents participated in the population-based cohorts, European Community Respiratory Heath Survey and Respiratory Health In Northern Europe, followed since the early 1990s when they were 20-44 years old, at 8-10 years intervals. Study protocols are harmonised across generations. FINDINGS TO DATE: Collected data include spirometry, skin prick tests, exhaled nitric oxide, anthropometrics, bioimpedance, blood pressure; questionnaire/interview data on respiratory/general/reproductive health, indoor/outdoor environment, smoking, occupation, general characteristics and lifestyle; biobanked blood, urine, gingival fluid, skin swabs; measured specific and total IgE, DNA methylation, sex hormones and oral microbiome. Research results suggest that parental environment years before conception, in particular, father's exposures such as smoking and overweight, may be of key importance for asthma and lung function, and that there is an important susceptibility window in male prepuberty. Statistical analyses developed to approach causal inference suggest that these associations may be causal. DNA methylation studies suggest a mechanism for transfer of father's exposures to offspring health and disease through ... Article in Journal/Newspaper Iceland Umeå University: Publications (DiVA) Norway BMJ Open 12 6 e059434 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Allergy Asthma Chronic airways disease Epidemiology Public health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
spellingShingle |
Allergy Asthma Chronic airways disease Epidemiology Public health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Svanes, Cecilie Johannessen, Ane Jacobsen Bertelsen, Randi Dharmage, Shyamali Benediktsdottir, Bryndis Bråbäck, Lennart Gislason, Thorarinn Holm, Mathias Jõgi, Oskar Lodge, Caroline J. Malinovschi, Andrei Martinez-Moratalla, Jesus Oudin, Anna Sánchez-Ramos, José Luis Timm, Signe Janson, Christer Real, Francisco Gomez Schlünssen, Vivi Cohort profile : the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
topic_facet |
Allergy Asthma Chronic airways disease Epidemiology Public health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
description |
PURPOSE: The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, particularly allergies and respiratory health, (2) identify susceptible time windows and (3) explore underlying mechanisms. The ultimate aim is to facilitate efficient intervention strategies targeting multiple generations. PARTICIPANTS: RHINESSA includes study participants of multiple generations from ten study centres in Norway (1), Denmark (1), Sweden (3), Iceland (1), Estonia (1), Spain (2) and Australia (1). The RHINESSA core cohort, adult offspring generation 3 (G3), was first investigated in 2014-17 in a questionnaire study (N=8818, age 18-53 years) and a clinical study (subsample, n=1405). Their G2 parents participated in the population-based cohorts, European Community Respiratory Heath Survey and Respiratory Health In Northern Europe, followed since the early 1990s when they were 20-44 years old, at 8-10 years intervals. Study protocols are harmonised across generations. FINDINGS TO DATE: Collected data include spirometry, skin prick tests, exhaled nitric oxide, anthropometrics, bioimpedance, blood pressure; questionnaire/interview data on respiratory/general/reproductive health, indoor/outdoor environment, smoking, occupation, general characteristics and lifestyle; biobanked blood, urine, gingival fluid, skin swabs; measured specific and total IgE, DNA methylation, sex hormones and oral microbiome. Research results suggest that parental environment years before conception, in particular, father's exposures such as smoking and overweight, may be of key importance for asthma and lung function, and that there is an important susceptibility window in male prepuberty. Statistical analyses developed to approach causal inference suggest that these associations may be causal. DNA methylation studies suggest a mechanism for transfer of father's exposures to offspring health and disease through ... |
format |
Article in Journal/Newspaper |
author |
Svanes, Cecilie Johannessen, Ane Jacobsen Bertelsen, Randi Dharmage, Shyamali Benediktsdottir, Bryndis Bråbäck, Lennart Gislason, Thorarinn Holm, Mathias Jõgi, Oskar Lodge, Caroline J. Malinovschi, Andrei Martinez-Moratalla, Jesus Oudin, Anna Sánchez-Ramos, José Luis Timm, Signe Janson, Christer Real, Francisco Gomez Schlünssen, Vivi |
author_facet |
Svanes, Cecilie Johannessen, Ane Jacobsen Bertelsen, Randi Dharmage, Shyamali Benediktsdottir, Bryndis Bråbäck, Lennart Gislason, Thorarinn Holm, Mathias Jõgi, Oskar Lodge, Caroline J. Malinovschi, Andrei Martinez-Moratalla, Jesus Oudin, Anna Sánchez-Ramos, José Luis Timm, Signe Janson, Christer Real, Francisco Gomez Schlünssen, Vivi |
author_sort |
Svanes, Cecilie |
title |
Cohort profile : the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
title_short |
Cohort profile : the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
title_full |
Cohort profile : the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
title_fullStr |
Cohort profile : the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
title_full_unstemmed |
Cohort profile : the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
title_sort |
cohort profile : the multigeneration respiratory health in northern europe, spain and australia (rhinessa) cohort |
publisher |
Umeå universitet, Avdelningen för hållbar hälsa |
publishDate |
2022 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199254 https://doi.org/10.1136/bmjopen-2021-059434 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
BMJ Open, 2022, 12:6, http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199254 doi:10.1136/bmjopen-2021-059434 PMID 35654464 ISI:000807081800035 Scopus 2-s2.0-85131231942 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1136/bmjopen-2021-059434 |
container_title |
BMJ Open |
container_volume |
12 |
container_issue |
6 |
container_start_page |
e059434 |
_version_ |
1779316035965419520 |