Anti-Saccharomyces Cerevisiae antibodies are only modestly more common in subjects later developing Crohn's disease
Background: The pathogenic processes in the preclinical phase of inflammatory bowel disease (IBD) are mainly unknown. Aims: To study typical antibodies for IBD in the preclinical phase in a cohort of Northern Sweden. Methods: Antibodies typical for IBD (ASCA, pANCA, lactoferrin-ANCA, antibodies to g...
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Umeå universitet, Institutionen för klinisk mikrobiologi
2023
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199100 https://doi.org/10.1007/s10620-022-07630-5 |
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ftumeauniv:oai:DiVA.org:umu-199100 2023-10-09T21:54:35+02:00 Anti-Saccharomyces Cerevisiae antibodies are only modestly more common in subjects later developing Crohn's disease Bodecker-Zingmark, L. Widbom, Lovisa Hultdin, Johan Eriksson, Catharina Karling, Pontus 2023 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199100 https://doi.org/10.1007/s10620-022-07630-5 eng eng Umeå universitet, Institutionen för klinisk mikrobiologi Umeå universitet, Klinisk kemi Umeå universitet, Avdelningen för medicin Digestive Diseases and Sciences, 0163-2116, 2023, 68, s. 608-615 orcid:0000-0002-9599-0961 orcid:0000-0002-5607-0118 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199100 doi:10.1007/s10620-022-07630-5 PMID 35989383 ISI:000842443300007 Scopus 2-s2.0-85136572563 info:eu-repo/semantics/openAccess ASCA Calprotectin Crohn's disease Inflammatory bowel disease Ulcerative colitis Gastroenterology and Hepatology Gastroenterologi Article in journal info:eu-repo/semantics/article text 2023 ftumeauniv https://doi.org/10.1007/s10620-022-07630-5 2023-09-22T14:00:18Z Background: The pathogenic processes in the preclinical phase of inflammatory bowel disease (IBD) are mainly unknown. Aims: To study typical antibodies for IBD in the preclinical phase in a cohort of Northern Sweden. Methods: Antibodies typical for IBD (ASCA, pANCA, lactoferrin-ANCA, antibodies to goblet cells, and pancreas antigen) were analyzed in 123 subjects with preclinical ulcerative colitis (UC), 54 subjects with preclinical Crohn's disease (CD) and in 390 sex- and age-matched controls. In addition, in a subset of subjects, inflammatory markers (CRP, albumin, calprotectin and ferritin) were measured in plasma. Results: The mean years between blood samples and IBD diagnosis were for UC 5.1 (SD 3.5) years and CD 5.6 (SD 3.5) years. There was no difference in the proportion of overall positive antibodies between subjects who later developed IBD compared to controls (16.9% vs. 12.3%; p = 0.137). The subjects who later developed CD had a significantly higher proportion of positive ASCA compared to controls (9.3% vs 2.8%; p = 0.034), but for all other antibodies, there were no differences compared to control subjects. Subjects with preclinical IBD and elevated antibodies showed significantly higher plasma calprotectin levels compared to subjects without antibodies (980 μg/L vs 756 μg/L; p = 0.042), but there was no difference in the levels of CRP, albumin and ferritin. Conclusions: We found no significant increase in antibodies typical for IBD years before diagnosis except for ASCA, which was slightly more common in subjects who later developed CD. Very few subjects had detectable antibodies to goblet cells and pancreas antigen. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Digestive Diseases and Sciences |
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Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
ASCA Calprotectin Crohn's disease Inflammatory bowel disease Ulcerative colitis Gastroenterology and Hepatology Gastroenterologi |
spellingShingle |
ASCA Calprotectin Crohn's disease Inflammatory bowel disease Ulcerative colitis Gastroenterology and Hepatology Gastroenterologi Bodecker-Zingmark, L. Widbom, Lovisa Hultdin, Johan Eriksson, Catharina Karling, Pontus Anti-Saccharomyces Cerevisiae antibodies are only modestly more common in subjects later developing Crohn's disease |
topic_facet |
ASCA Calprotectin Crohn's disease Inflammatory bowel disease Ulcerative colitis Gastroenterology and Hepatology Gastroenterologi |
description |
Background: The pathogenic processes in the preclinical phase of inflammatory bowel disease (IBD) are mainly unknown. Aims: To study typical antibodies for IBD in the preclinical phase in a cohort of Northern Sweden. Methods: Antibodies typical for IBD (ASCA, pANCA, lactoferrin-ANCA, antibodies to goblet cells, and pancreas antigen) were analyzed in 123 subjects with preclinical ulcerative colitis (UC), 54 subjects with preclinical Crohn's disease (CD) and in 390 sex- and age-matched controls. In addition, in a subset of subjects, inflammatory markers (CRP, albumin, calprotectin and ferritin) were measured in plasma. Results: The mean years between blood samples and IBD diagnosis were for UC 5.1 (SD 3.5) years and CD 5.6 (SD 3.5) years. There was no difference in the proportion of overall positive antibodies between subjects who later developed IBD compared to controls (16.9% vs. 12.3%; p = 0.137). The subjects who later developed CD had a significantly higher proportion of positive ASCA compared to controls (9.3% vs 2.8%; p = 0.034), but for all other antibodies, there were no differences compared to control subjects. Subjects with preclinical IBD and elevated antibodies showed significantly higher plasma calprotectin levels compared to subjects without antibodies (980 μg/L vs 756 μg/L; p = 0.042), but there was no difference in the levels of CRP, albumin and ferritin. Conclusions: We found no significant increase in antibodies typical for IBD years before diagnosis except for ASCA, which was slightly more common in subjects who later developed CD. Very few subjects had detectable antibodies to goblet cells and pancreas antigen. |
format |
Article in Journal/Newspaper |
author |
Bodecker-Zingmark, L. Widbom, Lovisa Hultdin, Johan Eriksson, Catharina Karling, Pontus |
author_facet |
Bodecker-Zingmark, L. Widbom, Lovisa Hultdin, Johan Eriksson, Catharina Karling, Pontus |
author_sort |
Bodecker-Zingmark, L. |
title |
Anti-Saccharomyces Cerevisiae antibodies are only modestly more common in subjects later developing Crohn's disease |
title_short |
Anti-Saccharomyces Cerevisiae antibodies are only modestly more common in subjects later developing Crohn's disease |
title_full |
Anti-Saccharomyces Cerevisiae antibodies are only modestly more common in subjects later developing Crohn's disease |
title_fullStr |
Anti-Saccharomyces Cerevisiae antibodies are only modestly more common in subjects later developing Crohn's disease |
title_full_unstemmed |
Anti-Saccharomyces Cerevisiae antibodies are only modestly more common in subjects later developing Crohn's disease |
title_sort |
anti-saccharomyces cerevisiae antibodies are only modestly more common in subjects later developing crohn's disease |
publisher |
Umeå universitet, Institutionen för klinisk mikrobiologi |
publishDate |
2023 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199100 https://doi.org/10.1007/s10620-022-07630-5 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Digestive Diseases and Sciences, 0163-2116, 2023, 68, s. 608-615 orcid:0000-0002-9599-0961 orcid:0000-0002-5607-0118 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199100 doi:10.1007/s10620-022-07630-5 PMID 35989383 ISI:000842443300007 Scopus 2-s2.0-85136572563 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1007/s10620-022-07630-5 |
container_title |
Digestive Diseases and Sciences |
_version_ |
1779318209833336832 |