Incidence, remission, and persistence of Raynaud’s phenomenon in the general population of northern Sweden : a prospective study
Background: Raynaud’s phenomenon is common condition, but little is known about the natural course. The primary aim of this study was to determine the incidence, remission, and persistence proportions of Raynaud’s phenomenon in the general population of northern Sweden. Secondary aims were to determ...
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Umeå universitet, Avdelningen för hållbar hälsa
2022
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198289 https://doi.org/10.1186/s41927-022-00272-0 |
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ftumeauniv:oai:DiVA.org:umu-198289 2023-10-09T21:54:29+02:00 Incidence, remission, and persistence of Raynaud’s phenomenon in the general population of northern Sweden : a prospective study Stjernbrandt, Albin Pettersson, Hans Lundström, Ronnie Liljelind, Ingrid Nilsson, Tohr Wahlström, Jens 2022 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198289 https://doi.org/10.1186/s41927-022-00272-0 eng eng Umeå universitet, Avdelningen för hållbar hälsa BMC Rheumatology, 2520-1026, 2022, 6:1, orcid:0000-0001-6082-8465 orcid:0000-0001-7077-2389 orcid:0000-0002-4918-9081 orcid:0000-0002-5936-1172 orcid:0000-0002-2359-509x http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198289 doi:10.1186/s41927-022-00272-0 PMID 35858907 ISI:000829607200001 Scopus 2-s2.0-85134530221 info:eu-repo/semantics/openAccess Cold climate Incidence Longitudinal studies Occupational exposure Peripheral vascular diseases Raynaud disease Remission Spontaneous Sweden Occupational Health and Environmental Health Arbetsmedicin och miljömedicin Article in journal info:eu-repo/semantics/article text 2022 ftumeauniv https://doi.org/10.1186/s41927-022-00272-0 2023-09-22T13:56:33Z Background: Raynaud’s phenomenon is common condition, but little is known about the natural course. The primary aim of this study was to determine the incidence, remission, and persistence proportions of Raynaud’s phenomenon in the general population of northern Sweden. Secondary aims were to determine how individual and exposure factors affect the course of Raynaud’s phenomenon, and to assess gender differences. Methods: A prospective, survey-based, closed-cohort study was conducted on a sample of men and women between 18–70 years of age, living in northern Sweden. Data on Raynaud’s phenomenon characteristics and general health status were collected during the winters of 2015 (baseline) and 2021 (follow-up). Rates of incidence, remission, and persistence were calculated. Binary logistic regression was used to determine the association between baseline variables and the course of Raynaud’s phenomenon. Results: The study population consisted of 2703 women (53.9%) and 2314 men. There were 390 women (14.5%) and 290 men (12.7%) reporting Raynaud’s phenomenon in the follow-up survey. The annual incidence proportion was 0.7% among women and 0.9% among men (gender difference p = 0.04). The annual remission proportion was 4.4% and 5.5%, respectively (p = 0.05). Having sustained a cold injury affecting the hands since baseline was significantly associated with incident Raynaud’s phenomenon (OR 3.92; 95% CI 2.60–5.90), after adjusting for age and gender. Conclusions: In the general population of northern Sweden, Raynaud’s phenomenon is a common but variable condition, where symptoms may remit over time. Men had a higher incidence proportion than women. The results support a possible causal pathway where cold injury can precede the onset of Raynaud’s phenomenon. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) BMC Rheumatology 6 1 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Cold climate Incidence Longitudinal studies Occupational exposure Peripheral vascular diseases Raynaud disease Remission Spontaneous Sweden Occupational Health and Environmental Health Arbetsmedicin och miljömedicin |
spellingShingle |
Cold climate Incidence Longitudinal studies Occupational exposure Peripheral vascular diseases Raynaud disease Remission Spontaneous Sweden Occupational Health and Environmental Health Arbetsmedicin och miljömedicin Stjernbrandt, Albin Pettersson, Hans Lundström, Ronnie Liljelind, Ingrid Nilsson, Tohr Wahlström, Jens Incidence, remission, and persistence of Raynaud’s phenomenon in the general population of northern Sweden : a prospective study |
topic_facet |
Cold climate Incidence Longitudinal studies Occupational exposure Peripheral vascular diseases Raynaud disease Remission Spontaneous Sweden Occupational Health and Environmental Health Arbetsmedicin och miljömedicin |
description |
Background: Raynaud’s phenomenon is common condition, but little is known about the natural course. The primary aim of this study was to determine the incidence, remission, and persistence proportions of Raynaud’s phenomenon in the general population of northern Sweden. Secondary aims were to determine how individual and exposure factors affect the course of Raynaud’s phenomenon, and to assess gender differences. Methods: A prospective, survey-based, closed-cohort study was conducted on a sample of men and women between 18–70 years of age, living in northern Sweden. Data on Raynaud’s phenomenon characteristics and general health status were collected during the winters of 2015 (baseline) and 2021 (follow-up). Rates of incidence, remission, and persistence were calculated. Binary logistic regression was used to determine the association between baseline variables and the course of Raynaud’s phenomenon. Results: The study population consisted of 2703 women (53.9%) and 2314 men. There were 390 women (14.5%) and 290 men (12.7%) reporting Raynaud’s phenomenon in the follow-up survey. The annual incidence proportion was 0.7% among women and 0.9% among men (gender difference p = 0.04). The annual remission proportion was 4.4% and 5.5%, respectively (p = 0.05). Having sustained a cold injury affecting the hands since baseline was significantly associated with incident Raynaud’s phenomenon (OR 3.92; 95% CI 2.60–5.90), after adjusting for age and gender. Conclusions: In the general population of northern Sweden, Raynaud’s phenomenon is a common but variable condition, where symptoms may remit over time. Men had a higher incidence proportion than women. The results support a possible causal pathway where cold injury can precede the onset of Raynaud’s phenomenon. |
format |
Article in Journal/Newspaper |
author |
Stjernbrandt, Albin Pettersson, Hans Lundström, Ronnie Liljelind, Ingrid Nilsson, Tohr Wahlström, Jens |
author_facet |
Stjernbrandt, Albin Pettersson, Hans Lundström, Ronnie Liljelind, Ingrid Nilsson, Tohr Wahlström, Jens |
author_sort |
Stjernbrandt, Albin |
title |
Incidence, remission, and persistence of Raynaud’s phenomenon in the general population of northern Sweden : a prospective study |
title_short |
Incidence, remission, and persistence of Raynaud’s phenomenon in the general population of northern Sweden : a prospective study |
title_full |
Incidence, remission, and persistence of Raynaud’s phenomenon in the general population of northern Sweden : a prospective study |
title_fullStr |
Incidence, remission, and persistence of Raynaud’s phenomenon in the general population of northern Sweden : a prospective study |
title_full_unstemmed |
Incidence, remission, and persistence of Raynaud’s phenomenon in the general population of northern Sweden : a prospective study |
title_sort |
incidence, remission, and persistence of raynaud’s phenomenon in the general population of northern sweden : a prospective study |
publisher |
Umeå universitet, Avdelningen för hållbar hälsa |
publishDate |
2022 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198289 https://doi.org/10.1186/s41927-022-00272-0 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
BMC Rheumatology, 2520-1026, 2022, 6:1, orcid:0000-0001-6082-8465 orcid:0000-0001-7077-2389 orcid:0000-0002-4918-9081 orcid:0000-0002-5936-1172 orcid:0000-0002-2359-509x http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198289 doi:10.1186/s41927-022-00272-0 PMID 35858907 ISI:000829607200001 Scopus 2-s2.0-85134530221 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/s41927-022-00272-0 |
container_title |
BMC Rheumatology |
container_volume |
6 |
container_issue |
1 |
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1779318064417865728 |