Outbreak of Cryptosporidium hominis in northern Sweden : persisting symptoms in a 5-year follow-up
In 2010–2011, a waterborne outbreak of the parasite, Cryptosporidium hominis, affected approximately 27,000 inhabitants in the city of Östersund, Sweden. Previous research suggested that post-infectious symptoms, such as gastrointestinal symptoms and joint pain, could persist for up to 2 years after...
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Umeå universitet, Allmänmedicin
2022
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194898 https://doi.org/10.1007/s00436-022-07524-5 |
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ftumeauniv:oai:DiVA.org:umu-194898 2023-12-24T10:23:38+01:00 Outbreak of Cryptosporidium hominis in northern Sweden : persisting symptoms in a 5-year follow-up Sjöström, Malin Arvidsson, M. Söderström, L. Lilja, Mikael Lindh, J. Widerström, Micael 2022 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194898 https://doi.org/10.1007/s00436-022-07524-5 eng eng Umeå universitet, Allmänmedicin Umeå universitet, Institutionen för klinisk mikrobiologi Unit of Research, Education and Development–Östersund Hospital, Östersund, Sweden Department of Cell and Molecular Biology, BMC, Uppsala University, Uppsala, Sweden Parasitology Research, 0932-0113, 2022, 121, s. 2043-2049 orcid:0000-0003-0868-6249 orcid:0000-0002-5203-9877 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194898 doi:10.1007/s00436-022-07524-5 PMID 35451705 ISI:000785587000001 Scopus 2-s2.0-85129469551 info:eu-repo/semantics/openAccess Cryptosporidium Diarrhoea Disease outbreaks Post-infectious symptoms Sequelae Infectious Medicine Infektionsmedicin Microbiology in the medical area Mikrobiologi inom det medicinska området Article in journal info:eu-repo/semantics/article text 2022 ftumeauniv https://doi.org/10.1007/s00436-022-07524-5 2023-11-29T23:36:28Z In 2010–2011, a waterborne outbreak of the parasite, Cryptosporidium hominis, affected approximately 27,000 inhabitants in the city of Östersund, Sweden. Previous research suggested that post-infectious symptoms, such as gastrointestinal symptoms and joint pain, could persist for up to 2 years after the initial infection. In this study, we investigated whether the parasite caused post-infectious sequelae for up to 5 years after the outbreak. Prospective cohort study. A randomly selected cohort of individuals residing in Östersund at the time of the outbreak was sent a postal questionnaire in 2011. Responders were sent a follow-up questionnaire in 2016 and completed items on whether they experienced a list of symptoms. We examined whether outbreak cases were more likely than non-cases to report post-infectious symptoms 5 years later. We analysed data using logistic regression and calculated odds ratios with 95% confidence intervals. The analysis included 626 individuals. Among the 262 individuals infected during the outbreak, 56.5% reported symptoms at follow-up. Compared to non-cases, outbreak cases were more likely to report watery diarrhoea, diarrhoea, swollen joints, abdominal pain, bloating, joint discomfort, acid indigestion, alternating bowel habits, joint pain, ocular pain, nausea, and fatigue at the follow-up, after adjusting for age and sex. Our findings suggested that cryptosporidiosis was mainly associated with gastrointestinal- and joint-related post-infectious symptoms for up to 5 years after the infection. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Parasitology Research 121 7 2043 2049 |
institution |
Open Polar |
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Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Cryptosporidium Diarrhoea Disease outbreaks Post-infectious symptoms Sequelae Infectious Medicine Infektionsmedicin Microbiology in the medical area Mikrobiologi inom det medicinska området |
spellingShingle |
Cryptosporidium Diarrhoea Disease outbreaks Post-infectious symptoms Sequelae Infectious Medicine Infektionsmedicin Microbiology in the medical area Mikrobiologi inom det medicinska området Sjöström, Malin Arvidsson, M. Söderström, L. Lilja, Mikael Lindh, J. Widerström, Micael Outbreak of Cryptosporidium hominis in northern Sweden : persisting symptoms in a 5-year follow-up |
topic_facet |
Cryptosporidium Diarrhoea Disease outbreaks Post-infectious symptoms Sequelae Infectious Medicine Infektionsmedicin Microbiology in the medical area Mikrobiologi inom det medicinska området |
description |
In 2010–2011, a waterborne outbreak of the parasite, Cryptosporidium hominis, affected approximately 27,000 inhabitants in the city of Östersund, Sweden. Previous research suggested that post-infectious symptoms, such as gastrointestinal symptoms and joint pain, could persist for up to 2 years after the initial infection. In this study, we investigated whether the parasite caused post-infectious sequelae for up to 5 years after the outbreak. Prospective cohort study. A randomly selected cohort of individuals residing in Östersund at the time of the outbreak was sent a postal questionnaire in 2011. Responders were sent a follow-up questionnaire in 2016 and completed items on whether they experienced a list of symptoms. We examined whether outbreak cases were more likely than non-cases to report post-infectious symptoms 5 years later. We analysed data using logistic regression and calculated odds ratios with 95% confidence intervals. The analysis included 626 individuals. Among the 262 individuals infected during the outbreak, 56.5% reported symptoms at follow-up. Compared to non-cases, outbreak cases were more likely to report watery diarrhoea, diarrhoea, swollen joints, abdominal pain, bloating, joint discomfort, acid indigestion, alternating bowel habits, joint pain, ocular pain, nausea, and fatigue at the follow-up, after adjusting for age and sex. Our findings suggested that cryptosporidiosis was mainly associated with gastrointestinal- and joint-related post-infectious symptoms for up to 5 years after the infection. |
format |
Article in Journal/Newspaper |
author |
Sjöström, Malin Arvidsson, M. Söderström, L. Lilja, Mikael Lindh, J. Widerström, Micael |
author_facet |
Sjöström, Malin Arvidsson, M. Söderström, L. Lilja, Mikael Lindh, J. Widerström, Micael |
author_sort |
Sjöström, Malin |
title |
Outbreak of Cryptosporidium hominis in northern Sweden : persisting symptoms in a 5-year follow-up |
title_short |
Outbreak of Cryptosporidium hominis in northern Sweden : persisting symptoms in a 5-year follow-up |
title_full |
Outbreak of Cryptosporidium hominis in northern Sweden : persisting symptoms in a 5-year follow-up |
title_fullStr |
Outbreak of Cryptosporidium hominis in northern Sweden : persisting symptoms in a 5-year follow-up |
title_full_unstemmed |
Outbreak of Cryptosporidium hominis in northern Sweden : persisting symptoms in a 5-year follow-up |
title_sort |
outbreak of cryptosporidium hominis in northern sweden : persisting symptoms in a 5-year follow-up |
publisher |
Umeå universitet, Allmänmedicin |
publishDate |
2022 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194898 https://doi.org/10.1007/s00436-022-07524-5 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Parasitology Research, 0932-0113, 2022, 121, s. 2043-2049 orcid:0000-0003-0868-6249 orcid:0000-0002-5203-9877 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194898 doi:10.1007/s00436-022-07524-5 PMID 35451705 ISI:000785587000001 Scopus 2-s2.0-85129469551 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1007/s00436-022-07524-5 |
container_title |
Parasitology Research |
container_volume |
121 |
container_issue |
7 |
container_start_page |
2043 |
op_container_end_page |
2049 |
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1786197755226488832 |