Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits
The present study assessed the temporal associations of ~ 300 lifestyle exposures with nine cardiometabolic traits to identify exposures/exposure groups that might inform lifestyle interventions for the reduction of cardiometabolic disease risk. The analyses were undertaken in a longitudinal sample...
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Umeå universitet, Avdelningen för medicin
2022
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ftumeauniv:oai:DiVA.org:umu-193212 2023-10-09T21:54:33+02:00 Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits Poveda, Alaitz Pomares-Millan, Hugo Chen, Yan Kurbasic, Azra Patel, Chirag J. Renström, Frida Hallmans, Göran Johansson, Ingegerd Franks, Paul W. 2022 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193212 https://doi.org/10.1038/s41598-022-08050-1 eng eng Umeå universitet, Avdelningen för medicin Umeå universitet, Avdelningen för hållbar hälsa Umeå universitet, Institutionen för odontologi Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Department of Biomedical Informatics, Harvard Medical School, MA, Boston, United States Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden; Division of Endocrinology and Diabetes, Cantonal Hospital St. Gallen, St. Gallen, Switzerland Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States Scientific Reports, 2022, 12:1, orcid:0000-0001-9581-3845 orcid:0000-0002-9227-8434 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193212 doi:10.1038/s41598-022-08050-1 PMID 35260745 ISI:000826474600156 Scopus 2-s2.0-85126079444 info:eu-repo/semantics/openAccess Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Article in journal info:eu-repo/semantics/article text 2022 ftumeauniv https://doi.org/10.1038/s41598-022-08050-1 2023-09-22T14:01:35Z The present study assessed the temporal associations of ~ 300 lifestyle exposures with nine cardiometabolic traits to identify exposures/exposure groups that might inform lifestyle interventions for the reduction of cardiometabolic disease risk. The analyses were undertaken in a longitudinal sample comprising > 31,000 adults living in northern Sweden. Linear mixed models were used to assess the average associations of lifestyle exposures and linear regression models were used to test associations with 10-year change in the cardiometabolic traits. ‘Physical activity’ and ‘General Health’ were the exposure categories containing the highest number of ‘tentative signals’ in analyses assessing the average association of lifestyle variables, while ‘Tobacco use’ was the top category for the 10-year change association analyses. Eleven modifiable variables showed a consistent average association among the majority of cardiometabolic traits. These variables belonged to the domains: (i) Smoking, (ii) Beverage (filtered coffee), (iii) physical activity, (iv) alcohol intake, and (v) specific variables related to Nordic lifestyle (hunting/fishing during leisure time and boiled coffee consumption). We used an agnostic, data-driven approach to assess a wide range of established and novel risk factors for cardiometabolic disease. Our findings highlight key variables, along with their respective effect estimates, that might be prioritised for subsequent prediction models and lifestyle interventions. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Scientific Reports 12 1 |
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Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
spellingShingle |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Poveda, Alaitz Pomares-Millan, Hugo Chen, Yan Kurbasic, Azra Patel, Chirag J. Renström, Frida Hallmans, Göran Johansson, Ingegerd Franks, Paul W. Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits |
topic_facet |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
description |
The present study assessed the temporal associations of ~ 300 lifestyle exposures with nine cardiometabolic traits to identify exposures/exposure groups that might inform lifestyle interventions for the reduction of cardiometabolic disease risk. The analyses were undertaken in a longitudinal sample comprising > 31,000 adults living in northern Sweden. Linear mixed models were used to assess the average associations of lifestyle exposures and linear regression models were used to test associations with 10-year change in the cardiometabolic traits. ‘Physical activity’ and ‘General Health’ were the exposure categories containing the highest number of ‘tentative signals’ in analyses assessing the average association of lifestyle variables, while ‘Tobacco use’ was the top category for the 10-year change association analyses. Eleven modifiable variables showed a consistent average association among the majority of cardiometabolic traits. These variables belonged to the domains: (i) Smoking, (ii) Beverage (filtered coffee), (iii) physical activity, (iv) alcohol intake, and (v) specific variables related to Nordic lifestyle (hunting/fishing during leisure time and boiled coffee consumption). We used an agnostic, data-driven approach to assess a wide range of established and novel risk factors for cardiometabolic disease. Our findings highlight key variables, along with their respective effect estimates, that might be prioritised for subsequent prediction models and lifestyle interventions. |
format |
Article in Journal/Newspaper |
author |
Poveda, Alaitz Pomares-Millan, Hugo Chen, Yan Kurbasic, Azra Patel, Chirag J. Renström, Frida Hallmans, Göran Johansson, Ingegerd Franks, Paul W. |
author_facet |
Poveda, Alaitz Pomares-Millan, Hugo Chen, Yan Kurbasic, Azra Patel, Chirag J. Renström, Frida Hallmans, Göran Johansson, Ingegerd Franks, Paul W. |
author_sort |
Poveda, Alaitz |
title |
Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits |
title_short |
Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits |
title_full |
Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits |
title_fullStr |
Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits |
title_full_unstemmed |
Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits |
title_sort |
exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits |
publisher |
Umeå universitet, Avdelningen för medicin |
publishDate |
2022 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193212 https://doi.org/10.1038/s41598-022-08050-1 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Scientific Reports, 2022, 12:1, orcid:0000-0001-9581-3845 orcid:0000-0002-9227-8434 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193212 doi:10.1038/s41598-022-08050-1 PMID 35260745 ISI:000826474600156 Scopus 2-s2.0-85126079444 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/s41598-022-08050-1 |
container_title |
Scientific Reports |
container_volume |
12 |
container_issue |
1 |
_version_ |
1779318165577138176 |