An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment
Exposure to a cold climate is associated with an increased morbidity and mortality, but the specific mechanisms are largely unknown. People with cardiopulmonary disease and winter endurance athletes are particularly vulnerable. This study aimed to map multiple domains of airway responses to exercise...
Published in: | International Journal of Circumpolar Health |
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Umeå universitet, Avdelningen för medicin
2021
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181662 https://doi.org/10.1080/22423982.2021.1897213 |
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ftumeauniv:oai:DiVA.org:umu-181662 2023-10-09T21:50:46+02:00 An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment Eklund, Linda Schagatay, Filip Tufvesson, Ellen Sjöström, Rita Söderström, Lars Hanstock, Helen G. Sandström, Thomas Stenfors, Nikolai 2021 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181662 https://doi.org/10.1080/22423982.2021.1897213 eng eng Umeå universitet, Avdelningen för medicin Umeå universitet, Institutionen för samhällsmedicin och rehabilitering Unit of Research, Education and Development, Östersund Hospital, Östersund, Sweden Swedish Winter Sports Research Centre, Department of Health Sciences, Mid Sweden University, Östersund, Sweden International Journal of Circumpolar Health, 1239-9736, 2021, 80:1, orcid:0000-0003-3739-0084 orcid:0000-0003-3466-5150 orcid:0000-0002-1684-1301 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181662 doi:10.1080/22423982.2021.1897213 PMID 33685367 ISI:000626745700001 Scopus 2-s2.0-85102302227 info:eu-repo/semantics/openAccess asthma Cold temperature environmental chamber healthy physical activity respiratory symptoms Respiratory Medicine and Allergy Lungmedicin och allergi Sport and Fitness Sciences Idrottsvetenskap Article in journal info:eu-repo/semantics/article text 2021 ftumeauniv https://doi.org/10.1080/22423982.2021.1897213 2023-09-22T14:01:37Z Exposure to a cold climate is associated with an increased morbidity and mortality, but the specific mechanisms are largely unknown. People with cardiopulmonary disease and winter endurance athletes are particularly vulnerable. This study aimed to map multiple domains of airway responses to exercise in subzero temperature in healthy individuals. Thirty-one healthy subjects underwent whole-body exposures for 50 minutes on two occasions in an environmental chamber with intermittent moderate-intensity exercise in +10 °C and -10 °C. Lung function, plasma/urine CC16 , and symptoms were investigated before and after exposures. Compared to baseline, exercise in -10 °C decreased FEV1 (p=0.002), FEV1/FVC (p<0.001), and increased R20Hz (p=0.016), with no differences between exposures. Reactance increased after +10 °C (p=0.005), which differed (p=0.042) from a blunted response after exercise in -10 °C. Plasma CC16 increased significantly within exposures, without differences between exposures. Exercise in -10 °C elicited more intense symptoms from the upper airways, compared to +10 °C. Symptoms from the lower airways were few and mild. Short-duration moderate-intensity exercise in -10 °C induces mild symptoms from the lower airways, no lung function decrements or enhanced leakage of biomarkers of airway epithelial injury, and no peripheral bronchodilatation, compared to exercise in +10 °C. Article in Journal/Newspaper Circumpolar Health International Journal of Circumpolar Health Umeå University: Publications (DiVA) International Journal of Circumpolar Health 80 1 1897213 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
asthma Cold temperature environmental chamber healthy physical activity respiratory symptoms Respiratory Medicine and Allergy Lungmedicin och allergi Sport and Fitness Sciences Idrottsvetenskap |
spellingShingle |
asthma Cold temperature environmental chamber healthy physical activity respiratory symptoms Respiratory Medicine and Allergy Lungmedicin och allergi Sport and Fitness Sciences Idrottsvetenskap Eklund, Linda Schagatay, Filip Tufvesson, Ellen Sjöström, Rita Söderström, Lars Hanstock, Helen G. Sandström, Thomas Stenfors, Nikolai An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment |
topic_facet |
asthma Cold temperature environmental chamber healthy physical activity respiratory symptoms Respiratory Medicine and Allergy Lungmedicin och allergi Sport and Fitness Sciences Idrottsvetenskap |
description |
Exposure to a cold climate is associated with an increased morbidity and mortality, but the specific mechanisms are largely unknown. People with cardiopulmonary disease and winter endurance athletes are particularly vulnerable. This study aimed to map multiple domains of airway responses to exercise in subzero temperature in healthy individuals. Thirty-one healthy subjects underwent whole-body exposures for 50 minutes on two occasions in an environmental chamber with intermittent moderate-intensity exercise in +10 °C and -10 °C. Lung function, plasma/urine CC16 , and symptoms were investigated before and after exposures. Compared to baseline, exercise in -10 °C decreased FEV1 (p=0.002), FEV1/FVC (p<0.001), and increased R20Hz (p=0.016), with no differences between exposures. Reactance increased after +10 °C (p=0.005), which differed (p=0.042) from a blunted response after exercise in -10 °C. Plasma CC16 increased significantly within exposures, without differences between exposures. Exercise in -10 °C elicited more intense symptoms from the upper airways, compared to +10 °C. Symptoms from the lower airways were few and mild. Short-duration moderate-intensity exercise in -10 °C induces mild symptoms from the lower airways, no lung function decrements or enhanced leakage of biomarkers of airway epithelial injury, and no peripheral bronchodilatation, compared to exercise in +10 °C. |
format |
Article in Journal/Newspaper |
author |
Eklund, Linda Schagatay, Filip Tufvesson, Ellen Sjöström, Rita Söderström, Lars Hanstock, Helen G. Sandström, Thomas Stenfors, Nikolai |
author_facet |
Eklund, Linda Schagatay, Filip Tufvesson, Ellen Sjöström, Rita Söderström, Lars Hanstock, Helen G. Sandström, Thomas Stenfors, Nikolai |
author_sort |
Eklund, Linda |
title |
An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment |
title_short |
An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment |
title_full |
An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment |
title_fullStr |
An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment |
title_full_unstemmed |
An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment |
title_sort |
experimental exposure study revealing composite airway effects of physical exercise in a subzero environment |
publisher |
Umeå universitet, Avdelningen för medicin |
publishDate |
2021 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181662 https://doi.org/10.1080/22423982.2021.1897213 |
genre |
Circumpolar Health International Journal of Circumpolar Health |
genre_facet |
Circumpolar Health International Journal of Circumpolar Health |
op_relation |
International Journal of Circumpolar Health, 1239-9736, 2021, 80:1, orcid:0000-0003-3739-0084 orcid:0000-0003-3466-5150 orcid:0000-0002-1684-1301 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181662 doi:10.1080/22423982.2021.1897213 PMID 33685367 ISI:000626745700001 Scopus 2-s2.0-85102302227 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1080/22423982.2021.1897213 |
container_title |
International Journal of Circumpolar Health |
container_volume |
80 |
container_issue |
1 |
container_start_page |
1897213 |
_version_ |
1779313828831428608 |