Lysophospholipids as Predictive Markers of ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI)
The present study explored patterns of circulating metabolites and proteins that can predict future risk for ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI). We conducted a prospective nested case-control study in northern Sweden in individuals who deve...
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Umeå universitet, Avdelningen för medicin
2021
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ftumeauniv:oai:DiVA.org:umu-180158 2023-10-09T21:54:36+02:00 Lysophospholipids as Predictive Markers of ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI) Chorell, Elin Olsson, Tommy Jansson, Jan-Håkan Wennberg, Patrik 2021 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180158 https://doi.org/10.3390/metabo11010025 eng eng Umeå universitet, Avdelningen för medicin Umeå universitet, Allmänmedicin Metabolites, 2218-1989, 2021, 11:1, orcid:0000-0002-8057-1684 orcid:0000-0001-7768-1076 orcid:0000-0003-1962-5484 orcid:0000-0002-1617-6102 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180158 doi:10.3390/metabo11010025 PMID 33396480 ISI:000610405500001 Scopus 2-s2.0-85099103882 info:eu-repo/semantics/openAccess myocardial infarction ST-elevation non-ST-elevation metabolomics plasma protein lysophospholipids prediction risk factors Cardiac and Cardiovascular Systems Kardiologi Article in journal info:eu-repo/semantics/article text 2021 ftumeauniv https://doi.org/10.3390/metabo11010025 2023-09-22T13:57:56Z The present study explored patterns of circulating metabolites and proteins that can predict future risk for ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI). We conducted a prospective nested case-control study in northern Sweden in individuals who developed STEMI (N = 50) and NSTEMI (N = 50) within 5 years and individually matched controls (N = 100). Fasted plasma samples were subjected to multiplatform mass spectrometry-based metabolomics and multiplex protein analyses. Multivariate analyses were used to elucidate infarction-specific metabolite and protein risk profiles associated with future incident STEMI and NSTEMI. We found that altered lysophosphatidylcholine (LPC) to lysophosphatidylethanolamine (LPE) ratio predicted STEMI and NSTEMI events in different ways. In STEMI, lysophospholipids (mainly LPEs) were lower, whereas in NSTEMI, lysophospholipids (mainly LPEs) were higher. We found a similar response for all detected lysophospholipids but significant alterations only for those containing linoleic acid (C18:2, p < 0.05). Patients with STEMI had higher secretoglobin family 3A member 2 and tartrate-resistant acid phosphate type 5 and lower platelet-derived growth factor subunit A, which are proteins associated with atherosclerosis severity and plaque development mediated via altered phospholipid metabolism. In contrast, patients with NSTEMI had higher levels of proteins associated with inflammation and macrophage activation, including interleukin 6, C-reactive protein, chemerin, and cathepsin X and D. The STEMI risk marker profile includes factors closely related to the development of unstable plaque, including a higher LPC:LPE ratio, whereas NSTEMI is characterized by a lower LPC:LPE ratio and increased inflammation. Article in Journal/Newspaper Northern Sweden Umeå University: Publications (DiVA) Metabolites 11 1 25 |
institution |
Open Polar |
collection |
Umeå University: Publications (DiVA) |
op_collection_id |
ftumeauniv |
language |
English |
topic |
myocardial infarction ST-elevation non-ST-elevation metabolomics plasma protein lysophospholipids prediction risk factors Cardiac and Cardiovascular Systems Kardiologi |
spellingShingle |
myocardial infarction ST-elevation non-ST-elevation metabolomics plasma protein lysophospholipids prediction risk factors Cardiac and Cardiovascular Systems Kardiologi Chorell, Elin Olsson, Tommy Jansson, Jan-Håkan Wennberg, Patrik Lysophospholipids as Predictive Markers of ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI) |
topic_facet |
myocardial infarction ST-elevation non-ST-elevation metabolomics plasma protein lysophospholipids prediction risk factors Cardiac and Cardiovascular Systems Kardiologi |
description |
The present study explored patterns of circulating metabolites and proteins that can predict future risk for ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI). We conducted a prospective nested case-control study in northern Sweden in individuals who developed STEMI (N = 50) and NSTEMI (N = 50) within 5 years and individually matched controls (N = 100). Fasted plasma samples were subjected to multiplatform mass spectrometry-based metabolomics and multiplex protein analyses. Multivariate analyses were used to elucidate infarction-specific metabolite and protein risk profiles associated with future incident STEMI and NSTEMI. We found that altered lysophosphatidylcholine (LPC) to lysophosphatidylethanolamine (LPE) ratio predicted STEMI and NSTEMI events in different ways. In STEMI, lysophospholipids (mainly LPEs) were lower, whereas in NSTEMI, lysophospholipids (mainly LPEs) were higher. We found a similar response for all detected lysophospholipids but significant alterations only for those containing linoleic acid (C18:2, p < 0.05). Patients with STEMI had higher secretoglobin family 3A member 2 and tartrate-resistant acid phosphate type 5 and lower platelet-derived growth factor subunit A, which are proteins associated with atherosclerosis severity and plaque development mediated via altered phospholipid metabolism. In contrast, patients with NSTEMI had higher levels of proteins associated with inflammation and macrophage activation, including interleukin 6, C-reactive protein, chemerin, and cathepsin X and D. The STEMI risk marker profile includes factors closely related to the development of unstable plaque, including a higher LPC:LPE ratio, whereas NSTEMI is characterized by a lower LPC:LPE ratio and increased inflammation. |
format |
Article in Journal/Newspaper |
author |
Chorell, Elin Olsson, Tommy Jansson, Jan-Håkan Wennberg, Patrik |
author_facet |
Chorell, Elin Olsson, Tommy Jansson, Jan-Håkan Wennberg, Patrik |
author_sort |
Chorell, Elin |
title |
Lysophospholipids as Predictive Markers of ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI) |
title_short |
Lysophospholipids as Predictive Markers of ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI) |
title_full |
Lysophospholipids as Predictive Markers of ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI) |
title_fullStr |
Lysophospholipids as Predictive Markers of ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI) |
title_full_unstemmed |
Lysophospholipids as Predictive Markers of ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI) |
title_sort |
lysophospholipids as predictive markers of st-elevation myocardial infarction (stemi) and non-st-elevation myocardial infarction (nstemi) |
publisher |
Umeå universitet, Avdelningen för medicin |
publishDate |
2021 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180158 https://doi.org/10.3390/metabo11010025 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
Metabolites, 2218-1989, 2021, 11:1, orcid:0000-0002-8057-1684 orcid:0000-0001-7768-1076 orcid:0000-0003-1962-5484 orcid:0000-0002-1617-6102 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180158 doi:10.3390/metabo11010025 PMID 33396480 ISI:000610405500001 Scopus 2-s2.0-85099103882 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/metabo11010025 |
container_title |
Metabolites |
container_volume |
11 |
container_issue |
1 |
container_start_page |
25 |
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1779318236251160576 |